ID G7YNM2_CLOSI Unreviewed; 320 AA.
AC G7YNM2;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Thyrotropin-releasing hormone receptor {ECO:0000256|ARBA:ARBA00018873};
DE AltName: Full=Thyroliberin receptor {ECO:0000256|ARBA:ARBA00032251};
DE Flags: Fragment;
GN ORFNames=CLF_103836 {ECO:0000313|EMBL:GAA54553.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA54553.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA54553.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA54553.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand
CC binding, this G-protein-coupled receptor triggers activation of the
CC phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.
CC {ECO:0000256|ARBA:ARBA00004100}.
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DR EMBL; DF143901; GAA54553.1; -; Genomic_DNA.
DR AlphaFoldDB; G7YNM2; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004997; F:thyrotropin-releasing hormone receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002120; TRH_rcpt_1.
DR PANTHER; PTHR46061; THYROTROPIN-RELEASING HORMONE RECEPTOR; 1.
DR PANTHER; PTHR46061:SF3; THYROTROPIN-RELEASING HORMONE RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:GAA54553.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 195..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 172..320
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT NON_TER 320
FT /evidence="ECO:0000313|EMBL:GAA54553.1"
SQ SEQUENCE 320 AA; 36820 MW; DEC81275A603376B CRC64;
MAEQQDYMRQ FSYAHLVNQN GNLPMFIGPE GPDCGSLDEV DDGVRTLEMF VFVRLHVVLP
PISALLWNRQ RFQHDDDDLY VPEVTSNQLE ARMTKLYFGE KAFNHIRSAF WSSASSSRVL
VDECGENLNA VNSYFPEEGN SNGNFRPKGR LLGNQSARDH LMWIPRLKDD PLQFQRWVGI
CHALRAHYMC TISRALRIVV LIWTFATLYN VPWMFIATTK QYGSEFSSYE VCTFTYERTY
YKTVYTFDLV VFYVIPVGVT SMLYSLICLR LFRKTVDLAS SQSEPSCRGI VYTADEVPLS
AARTQIQMCH AIDRAAARKQ
//
