ID G7YNP9_CLOSI Unreviewed; 1498 AA.
AC G7YNP9;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=Voltage-dependent calcium channel type A subunit alpha-1 {ECO:0000313|EMBL:GAA54580.1};
GN ORFNames=CLF_103982 {ECO:0000313|EMBL:GAA54580.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA54580.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA54580.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA54580.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR EMBL; DF143904; GAA54580.1; -; Genomic_DNA.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 3.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR Pfam; PF00520; Ion_trans; 5.
DR PRINTS; PR00167; CACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808}; Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 86..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 537..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 607..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 802..821
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 841..862
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 874..893
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 944..967
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1004..1030
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1075..1100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1130..1152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1247..1270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 50..247
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 374..448
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 515..653
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 803..1036
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1183..1280
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 675..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1421..1498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 639..675
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1423..1439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1453..1498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 196
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 591
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 1498 AA; 170915 MW; F9A19112D1787645 CRC64;
MIGANSVVVE LDPGRLVQIQ WLDPEGCSRL VTTCLVFANK LLAYILPNLN QPAVRALRVL
RPLKLVTGFE SLQIVLKSIL RAMAPLLQIS LLVLFAITIF AIIGLEFYSG AFHMTCFETL
NPDRLPLSLP NRANLAPCTP QNLASSTSGT RTQPGAFVCP ENYTCKGHWE GPNYGITSFD
NIGFAMLTVF QCITMEGWTD ILYHTDDAIG DRFNYLYFIP LIILGSFFML NLVLGVLSGE
FAKERERVEK RRAFLKLRRQ QQMEKEFNGY MDWIQRAEEV ILAEDTTTAE ERLRIISARK
RAEKQHAKQK QVKGGGPVDM AYDEAELLEE PKAGNLFGQS YGELLKRRKE RCQSCWRTEK
RIRYAIRRMV KSQACYWIVI VLVFLNTVCG AIEHHGQPIW LSNFLYYAEY VFLGLFIAEM
LLKMYGLKVH IYFESTFNIF DCAALPAASS VRELLRNTRE NGPFLDSVPN SKEVATQFIF
TLLRVLWRHR EHLILQTMLL KISSNAYKMF VGGRKTTRYW ASLRNLVLSL LNSMRSIISL
LFLLFLFILI FALLGMQLFG GDFNFDEGRP TQHFDTFVKA LLTVFQILTG EDWNTIMYNG
IRAQGGVSGG GGIYAVYFVL VMLVGNYRHI PDTLLNVFLA IAVDNLANAQ ELTEAEEEQK
LKEEMQANGE NMANEYHSEE SMSQAQTKPS QTLANQSPPI APLTCQRRIT GTSVANTWVE
GEKLAQAPLP FAQILQDGMN AERTRLESFG KLNMVSIESD DTARLQGSTQ QTQGKPILPY
SSMFIFAPNN AIRRFCHFVV NLRYFDLFIM IVICASSIAL AAEDPVWEHS SRNAILEHFD
YAFTGVFTIE LVLKVIDLGV VLHPGSYFRD AWNILDAIVV FFALVAFVVR HMGGNTSAKN
LNTIKSLRVL RVLRPLKTIN RVPKLKAVFD CVVSSLKNVS NILIVYWLFQ FIFAVIAVQL
FQGRFFYCND ISKMTKEECQ VLKHSIDTTS VDRGPIADFR QEMAVFYIVF FIVFPFFFVN
IFVALIIITF QKQGENELME MDIDKNQKRC IDFAINASPL CRYMPKDRNS LKYRIWRLVV
STPFECYIMV MIAINTLVLM MKYHRQEQKS STHVTMDTEQ QAYHNYCNTL LYFNSAFTVM
FSIECMLKIL AFGPKNYFRD RWNIFDFITV IGSITDVLVS ELQVFGNIRT NHLSQINDHN
NFKTFGNGLT LLFRCATGEN WQEIMLDCAA GSECERSQES CGSSFTYPYF VIFNFLCTFL
MLNLFIAVIM DNFDYLTRDS SILGPHHLDE FIRVWAEYDP GASVIVPPKF YLVKLFLFPF
EFHFAQRKQG THRSSAVSAS SQSTGTRQSK EGINIFSPVC NGSRALVEVP YPKMEETYLA
RRPSPSITSV DTEENSGHFV RRQSTFELSD ELKRRRSYFV QHHRPTDISQ GTSENMQEPG
GSEPDKDYQL DSRKTLVLST MPPSEYLEDA SQSEGPSPSD INEESQITGI TYSEETLL
//
