ID G7YNX4_CLOSI Unreviewed; 758 AA.
AC G7YNX4;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Solute carrier family 13 member 2 {ECO:0000313|EMBL:GAA54655.1};
GN ORFNames=CLF_104620 {ECO:0000313|EMBL:GAA54655.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA54655.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA54655.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA54655.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family.
CC NADC subfamily. {ECO:0000256|ARBA:ARBA00006772}.
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DR EMBL; DF143910; GAA54655.1; -; Genomic_DNA.
DR AlphaFoldDB; G7YNX4; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015556; F:C4-dicarboxylate transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0005310; F:dicarboxylic acid transmembrane transporter activity; IEA:UniProt.
DR GO; GO:1901702; F:salt transmembrane transporter activity; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001898; SLC13A/DASS.
DR PANTHER; PTHR10283:SF82; PROTEIN I'M NOT DEAD YET-RELATED; 1.
DR PANTHER; PTHR10283; SOLUTE CARRIER FAMILY 13 MEMBER; 1.
DR Pfam; PF00939; Na_sulph_symp; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 543..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 631..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 676..696
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 717..737
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 33..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 758 AA; 83995 MW; C109A047CB9A7E2C CRC64;
MLYKAFGHSG KKPLASAGED SLIRCVVGLR KPDELPSAHP KGDSHTSSDG DDLAEPVTLP
GSLLAQTLFR FEVGHPTVLA ASLCTQSYER LCAWAKHPML SRVIEALLNS PSVSLNRKSY
LISVFEPALF TLACTRFGSR VVESLWKATE QLEDTESVKE RLAGVLAKYR HKLNNNQYGH
FVHYKLQLNQ FAESRDLWRR RMFPRHEKAT GKKRNAPTEA VTENRYRCFH CNLYPKDTVM
LFVGGLFVAC TIEHRNLHRR IALSVLKVVG SDPKMLMLGV MLPTWFLSMW MSNTATTAMM
ITIVEAVIIS MDAIEVAIRE LNETRFVRSL SECLDSQRDS EVTEPRDKLP VASVGNQALA
VEHAPSPIDS KIDPESLDQE PIRYVNLRGF NTGLSLAVCY ASTCGGLATV TGTGPNAIFF
GQVNSRYGEM TGLNFGSWMA FALPISILTL LVTWIVLTMI YIGPKAFCLC KLDKDQALLV
RKVMHREYKK LGGFTYAEGS CCVLFALITS LWVTRNIGDF GWSKFFKSEK NPTQIYVSDS
QPAMLIALLA MTLPAVSPIE LWRLQYKRLS NSAETAELKN ESLLPWHVVQ KQVPWGIIFV
LGGGFALSDV CQHSGLSDVI GRYLMEHVNG LPVVGLVAVF SILGAFFTEL TSNAATISIL
LPILFSLSES MRIHPFLLTL PTTIATSFAF CLPAATPPNS IVFGRGRVRV KDMIKSGLFL
NFAGCLITLT ATITYAVPLF QMDTLPQWAV NITSTQPV
//
