ID G7Z8A7_AZOL4 Unreviewed; 1014 AA.
AC G7Z8A7;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN OrderedLocusNames=AZOLI_1958 {ECO:0000313|EMBL:CBS87206.1};
OS Azospirillum lipoferum (strain 4B).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Azospirillaceae; Azospirillum.
OX NCBI_TaxID=862719 {ECO:0000313|EMBL:CBS87206.1, ECO:0000313|Proteomes:UP000005667};
RN [1] {ECO:0000313|Proteomes:UP000005667}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4B {ECO:0000313|Proteomes:UP000005667};
RX PubMed=22216014; DOI=10.1371/journal.pgen.1002430;
RA Wisniewski-Dye F., Borziak K., Khalsa-Moyers G., Alexandre G.,
RA Sukharnikov L.O., Wuichet K., Hurst G.B., McDonald W.H., Robertson J.S.,
RA Barbe V., Calteau A., Rouy Z., Mangenot S., Prigent-Combaret C.,
RA Normand P., Boyer M., Siguier P., Dessaux Y., Elmerich C., Condemine G.,
RA Krishnen G., Kennedy I., Paterson A.H., Gonzalez V., Mavingui P.,
RA Zhulin I.B.;
RT "Azospirillum genomes reveal transition of bacteria from aquatic to
RT terrestrial environments.";
RL PLoS Genet. 7:E1002430-E1002430(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FQ311868; CBS87206.1; -; Genomic_DNA.
DR RefSeq; WP_014248208.1; NC_016622.1.
DR AlphaFoldDB; G7Z8A7; -.
DR STRING; 862719.AZOLI_1958; -.
DR KEGG; ali:AZOLI_1958; -.
DR HOGENOM; CLU_012369_0_0_5; -.
DR OrthoDB; 7311221at2; -.
DR Proteomes; UP000005667; Chromosome.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670}.
FT DOMAIN 142..334
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
SQ SEQUENCE 1014 AA; 111980 MW; C0CA77A01DE922BB CRC64;
MAKAWVQAGR WARRAVIGVA LTTTVAAVGY AGWREMETSR LQARLLSGVA QSMTVSLREG
PNPAARYPAH GPYNERLGYT ALPGQLDLLT RDIYAVEQQA VLSPALDRFM AGGGFPIYRE
KTQAGLTLLD RNGVPMYAAR YPERVFDGFD DVPKLVADTL LFIENRELLN EDEPRRNPAV
EWDRFGAAVA MLPLQMVRPG QRSPGGSTLA TQIEKYRHSP DGQTTGGVEK LRQMMSASIR
AYRDGEDTTE ARRRVLVDYL NSTPLTARAG FGEVNGLGDG LWAWFGTDLS IAKRVLAEPA
AEPRTLRLKA LAYKQVLALL LAQRRPSYYL IQDRTALDRL ADAHLRALAQ AGVIDPALRD
AALAIRLAFR EEAPSPPATS FIEQKATNAV RARLLGMLGV PSLYQLDRLD LTAQSTLDAE
TQARVVEVLG KLNDPDYART LGLTGERLLD ARNNDLSKLV YSITLYERGP EANYLRVQAD
NLDQPLDINE GAKLDLGSTA KLRTLVTYLQ IVAELHSRYA HLPKDFLADV EDEASDNLTR
WAASWLTTAQ DRRLPAMLDA AMERRYSANP GEVFFTGGGQ HSFVNFNKDD NGRIMTLQEA
LRSSVNLPFI RLMRDIVQFY MDEGADDGAE ILRTPDHPAR QAYLARFADR EGSDFLNRFY
NDYRKRTPDE ALVRLAARSR PVPYRLAVIF RTVRPKAGLA EFSAFLRARL PGSTLSDGEL
SALYAKYGPG RFPLNDLGYL ARVHPLELWL VAHLQNNPNA TRAEVLAASA DERQESYRWL
FKKGMAAQNT RIRIGLEEEA FKRITAQWRS VGYPFDTLVP SLATSIGSSA DRPAALAELM
GLILNDGVRQ PTVRIRSLHF AAGTPYEAKL GLGPLKGERV LHPEVCATLR RALMDVAQNG
TAKRVWGSFK DPAGTAVPMG GKTGTGDHRL ERWGPGGVLL ESKAVARTAT FVFYIGDRFF
GTMTAFVQGP EADDYRFTSA LPAQLLKSLA PALQPLIDQG ATRTADTRPA PAGL
//
