ID   G7ZTR8_STRSU            Unreviewed;       234 AA.
AC   G7ZTR8;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=UDP-N-acetylglucosamine kinase {ECO:0000256|ARBA:ARBA00011963};
DE            EC=2.7.1.176 {ECO:0000256|ARBA:ARBA00011963};
DE   AltName: Full=UDP-N-acetylglucosamine kinase {ECO:0000256|ARBA:ARBA00032897};
OS   Streptococcus suis.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1307 {ECO:0000313|EMBL:CBZ42045.1};
RN   [1] {ECO:0000313|EMBL:CBZ42045.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=32457 {ECO:0000313|EMBL:CBZ42045.1};
RX   PubMed=22710115; DOI=10.1128/AAC.00629-12;
RA   Palmieri C., Magi G., Mingoia M., Bagnarelli P., Ripa S., Varaldo P.E.,
RA   Facinelli B.;
RT   "Characterization of a Streptococcus suis tet(O/W/32/O)-Carrying Element
RT   Transferable to Major Streptococcal Pathogens.";
RL   Antimicrob. Agents Chemother. 56:4697-4702(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + UDP-N-acetyl-alpha-D-glucosamine = ADP + H(+) + UDP-N-
CC         acetyl-alpha-D-glucosamine 3'-phosphate; Xref=Rhea:RHEA:32671,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57705,
CC         ChEBI:CHEBI:64353, ChEBI:CHEBI:456216; EC=2.7.1.176;
CC         Evidence={ECO:0000256|ARBA:ARBA00000912};
CC   -!- SIMILARITY: Belongs to the zeta toxin family.
CC       {ECO:0000256|ARBA:ARBA00009104}.
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DR   EMBL; FR823304; CBZ42045.1; -; Genomic_DNA.
DR   AlphaFoldDB; G7ZTR8; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010488; Zeta_toxin_domain.
DR   Pfam; PF06414; Zeta_toxin; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Toxin-antitoxin system {ECO:0000256|ARBA:ARBA00022649}.
FT   DOMAIN          29..215
FT                   /note="Zeta toxin"
FT                   /evidence="ECO:0000259|Pfam:PF06414"
SQ   SEQUENCE   234 AA;  26560 MW;  D5A6B6627928E7F9 CRC64;
     MRLEEFSEAE FQKALQRTIR ALTRGKTIPD QPKAILLGGQ SGAGKTTIHR IKQKEFQGNI
     IIIDGDSYRS QHPNYLALQE KYGKDSVDYT KGFAGKMVEQ LVDELSTQGY HLLIEGTLRT
     TQVPRQTAQL LSSKGYQVSL AVIGTKPELS YLSTLIRYEE LYAIDPTQAR ATPKEHHDGI
     VENLVDNLRE LESENLFDQI QIYQRDRTCI YDSETAEGPQ QKCYKNAYLE NGAR
//