ID   G8A523_FLAVE            Unreviewed;       722 AA.
AC   G8A523;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   RecName: Full=Inositol oxygenase {ECO:0000256|ARBA:ARBA00019269};
DE            EC=1.13.99.1 {ECO:0000256|ARBA:ARBA00011919};
DE   AltName: Full=Myo-inositol oxygenase {ECO:0000256|ARBA:ARBA00029668};
OS   Flammulina velutipes (Agaricus velutipes).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Marasmiineae; Physalacriaceae; Flammulina.
OX   NCBI_TaxID=38945 {ECO:0000313|EMBL:ADX07297.1};
RN   [1] {ECO:0000313|EMBL:ADX07297.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KACC 42777 {ECO:0000313|EMBL:ADX07297.1};
RA   Yoon H., Kim J.-G., Lee B.-M., Kong W.-S., Lee C.-S., Choi J.-W.;
RT   "Useful genes from Flammulina velutipes.";
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=myo-inositol + O2 = D-glucuronate + H(+) + H2O;
CC         Xref=Rhea:RHEA:23696, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15379, ChEBI:CHEBI:17268, ChEBI:CHEBI:58720;
CC         EC=1.13.99.1; Evidence={ECO:0000256|ARBA:ARBA00000486};
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC         Evidence={ECO:0000256|ARBA:ARBA00001962};
CC   -!- PATHWAY: Polyol metabolism; myo-inositol degradation into D-
CC       glucuronate; D-glucuronate from myo-inositol: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00005167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the myo-inositol oxygenase family.
CC       {ECO:0000256|ARBA:ARBA00005286}.
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DR   EMBL; GU169862; ADX07297.1; -; mRNA.
DR   AlphaFoldDB; G8A523; -.
DR   UniPathway; UPA00111; UER00527.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0050113; F:inositol oxygenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR007828; Inositol_oxygenase.
DR   PANTHER; PTHR12588:SF0; INOSITOL OXYGENASE; 1.
DR   PANTHER; PTHR12588; MYOINOSITOL OXYGENASE; 1.
DR   Pfam; PF05153; MIOX; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
SQ   SEQUENCE   722 AA;  83064 MW;  CDE38930BC90F5EB CRC64;
     MPEHVNFKVL MATVLRGPKE SLASVRQLEE YFNKRMVFVG RHVLPAIRHH LKRINMISLE
     TADWPASPEI QNALSCFGMS ALMFERYKRE NVDFTPQVKE EITEPLWPLI RDWSLYFIQR
     SRVLEENSEP RNLDLIFLLE RVLSSFVRWI NVGIRYVRPG PYMDEFLMTI THLWVRCSAE
     LDISIPAMAD VLTASMSQEP SPGRFGPVSN TFTSKPPRDV AITVMNTAHN SIMSELVGYD
     IMTWMTRLAR RMTSKRAAFE FNIFEEEIEG VGSSIQLVFG AIHSLLILGY VALVQALESH
     VLEAAINSEI YLVRYFSEDS QYIESLRQQV AQILDGVVHF LDFRSVLNIA RRDIRHIEAS
     GVEEYIATGS SLLHKWLEFK DIVRSHQDAV ALYKDVILAK CANPQNVSEL TGSTDTRRTV
     HRFAVNVQRS ALWLGGVIVN VLKGKAKIAK DAEWNDKSTF DENKDKGQFR QYEEACERVK
     KFYYEQHEKQ TMDFNIKARV NFRKNVRARM GVWEAMEKLN TLVDNSDPDT DVSQIEHLLQ
     TAEAIRRDGK PEWMQVVGLV HDLGKLLYIF GSEGQWDVVG DTFVVGCQFS DKIIYPGSFA
     NNPDSEDPIY STEYGVYKPH CGLENVMLSW GHDEYLYHVF KEQSSLPEEG LAMIRYHSFY
     PWHREGAYAH LTNAADEKAL AAVRAFNPYD LYSKSDDPVD PAKLKPYYQG LIEIFFPEEI
     VW
//