ID G8B7S1_CANPC Unreviewed; 348 AA.
AC G8B7S1;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=NADP-dependent oxidoreductase domain-containing protein {ECO:0000259|Pfam:PF00248};
GN Name=LPG20 {ECO:0000313|CGD:CAL0000155463};
GN OrderedLocusNames=CPAR2_105420 {ECO:0000313|CGD:CAL0000155463,
GN ECO:0000313|EMBL:CCE40506.1};
OS Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia
OS parapsilosis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=578454 {ECO:0000313|EMBL:CCE40506.1, ECO:0000313|Proteomes:UP000005221};
RN [1] {ECO:0000313|Proteomes:UP000005221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0000313|Proteomes:UP000005221}
RP GENOME REANNOTATION.
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=22192698; DOI=10.1186/1471-2164-12-628;
RA Guida A., Lindstaedt C., Maguire S.L., Ding C., Higgins D.G., Corton N.J.,
RA Berriman M., Butler G.;
RT "Using RNA-seq to determine the transcriptional landscape and the hypoxic
RT response of the pathogenic yeast Candida parapsilosis.";
RL BMC Genomics 12:628-628(2011).
CC -!- SIMILARITY: Belongs to the aldo/keto reductase family.
CC {ECO:0000256|ARBA:ARBA00007905}.
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DR EMBL; HE605203; CCE40506.1; -; Genomic_DNA.
DR AlphaFoldDB; G8B7S1; -.
DR STRING; 578454.G8B7S1; -.
DR EnsemblFungi; CPAR2_105420-T; CPAR2_105420-T-p1; CPAR2_105420.
DR CGD; CAL0000155463; LPG20.
DR VEuPathDB; FungiDB:CPAR2_105420; -.
DR eggNOG; KOG1575; Eukaryota.
DR Proteomes; UP000005221; Chromosome 1.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:UniProt.
DR CDD; cd19079; AKR_EcYajO-like; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43364:SF15; ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED; 1.
DR PANTHER; PTHR43364; NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005221}.
FT DOMAIN 20..339
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
SQ SEQUENCE 348 AA; 39439 MW; 6759A2274F335EE2 CRC64;
MSIELKYNNL GESGLKIAPL IVGCMSYGSK KWAEWVLEDE EEIFKILKKC YDVGLRTFDT
ADVYSNGVSE VILGKFLKKY DIPRERVVIL TKCFMAMNPR DSGFNALRAG NLSDKDFANS
KGLSRKHVLD AVNASVERLG TYIDVLQIHR LDPTTPKKEI MKALNDVVDQ GLTRYIGAST
MKATEFAQLQ FIAEQNGWYK FISMQNYYNL IYREEEREMI PFCKNNDLSK VGIIPWSPIA
RGVLTRPVGE TSQNKRHESD KTFALLGLDA LTDVDTEIIK RVEKVAKERR ESMAVIATAW
VISKGCNPIV GLNSEKRVED IIRATSVKLS DEEIAYLEEP YKPKQSLS
//
