ID G8BIC3_CANPC Unreviewed; 520 AA.
AC G8BIC3;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=CP-type G domain-containing protein {ECO:0000259|PROSITE:PS51721};
GN OrderedLocusNames=CPAR2_401890 {ECO:0000313|CGD:CAL0000145687,
GN ECO:0000313|EMBL:CCE44388.1};
OS Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia
OS parapsilosis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=578454 {ECO:0000313|EMBL:CCE44388.1, ECO:0000313|Proteomes:UP000005221};
RN [1] {ECO:0000313|Proteomes:UP000005221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0000313|Proteomes:UP000005221}
RP GENOME REANNOTATION.
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=22192698; DOI=10.1186/1471-2164-12-628;
RA Guida A., Lindstaedt C., Maguire S.L., Ding C., Higgins D.G., Corton N.J.,
RA Berriman M., Butler G.;
RT "Using RNA-seq to determine the transcriptional landscape and the hypoxic
RT response of the pathogenic yeast Candida parapsilosis.";
RL BMC Genomics 12:628-628(2011).
CC -!- FUNCTION: May be involved in the mitochondrial lipid metabolism.
CC {ECO:0000256|ARBA:ARBA00003269}.
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DR EMBL; HE605208; CCE44388.1; -; Genomic_DNA.
DR AlphaFoldDB; G8BIC3; -.
DR STRING; 578454.G8BIC3; -.
DR EnsemblFungi; CPAR2_401890-T; CPAR2_401890-T-p1; CPAR2_401890.
DR CGD; CAL0000145687; CPAR2_401890.
DR VEuPathDB; FungiDB:CPAR2_401890; -.
DR eggNOG; KOG2484; Eukaryota.
DR Proteomes; UP000005221; Chromosome 4.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0005730; C:nucleolus; IEA:EnsemblFungi.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:EnsemblFungi.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IEA:EnsemblFungi.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0000055; P:ribosomal large subunit export from nucleus; IEA:EnsemblFungi.
DR CDD; cd04178; Nucleostemin_like; 1.
DR Gene3D; 1.10.1580.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030378; G_CP_dom.
DR InterPro; IPR014813; Gnl3_N_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11089; GTP-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11089:SF30; GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG; 1.
DR Pfam; PF08701; GN3L_Grn1; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51721; G_CP; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005221}.
FT DOMAIN 172..350
FT /note="CP-type G"
FT /evidence="ECO:0000259|PROSITE:PS51721"
FT REGION 1..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..34
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..51
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..93
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..113
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 520 AA; 57819 MW; A1F932EA31AB5D9C CRC64;
MRVKKPTSKR VTTRMREGIK KKAAAKRRKD KKIAKKDVTW KSRHRKDPGI PASFPYKDQI
ISELEDSRRL ERERREELKL QKQKEREEAL ARGEEVGDDE MEDEELEDED DGANGLAALL
ESAQSAAKEY NGEADNDDND MIDSDEDVEI ELSEVEDDEE DVAGLEKSRK SYDKIFKTVV
EASDVVLYVL DARDPESTRS KRVEQAVLQN PGKRLILLLN KVDLVPTEAL NQWLDFLNSS
FPTLPIKASP GATNATSFNK KLTGAITADS LMKALKSYAN KSNLKRSIIV GVIGYPNVGK
SSIINALTKR HNNNSKACPV GNQAGVTTSM REVKIDNKLK ILDSPGIVFP DEIINTKKQS
KQHQMAKLAL LSAIPPKSIT DPVVAVKLLL KKFSQNPEMA EGLKKYYDLP PLPSNDLEEF
VKHFLIHIAR TKGRLGRGGV PNLDSAAMAV LNDWRDGRII GWTLPKASKQ AAAEAEVNLE
GPKSALRGEK EPPKIEQTTV VTSWAKEFDL DGLLGNFGSE
//
