ID G8LS15_9FLAO Unreviewed; 441 AA.
AC G8LS15;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=GTPase Der {ECO:0000256|ARBA:ARBA00020953, ECO:0000256|HAMAP-Rule:MF_00195};
DE AltName: Full=GTP-binding protein EngA {ECO:0000256|HAMAP-Rule:MF_00195};
GN Name=der {ECO:0000256|HAMAP-Rule:MF_00195};
GN ORFNames=BLBCPU_345 {ECO:0000313|EMBL:AEU09388.1};
OS Blattabacterium sp. (Cryptocercus punctulatus) str. Cpu.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Blattabacteriaceae; Blattabacterium.
OX NCBI_TaxID=1075399 {ECO:0000313|EMBL:AEU09388.1, ECO:0000313|Proteomes:UP000007112};
RN [1] {ECO:0000313|EMBL:AEU09388.1, ECO:0000313|Proteomes:UP000007112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Cpu {ECO:0000313|EMBL:AEU09388.1,
RC ECO:0000313|Proteomes:UP000007112};
RX PubMed=22094859;
RA Neef A., Latorre A., Pereto J., Silva F.J., Pignatelli M., Moya A.;
RT "Genome economization in the endosymbiont of the wood roach Cryptocercus
RT punctulatus due to drastic loss of amino acid synthesis capabilities.";
RL Genome Biol. Evol. 3:1437-1448(2011).
CC -!- FUNCTION: GTPase that plays an essential role in the late steps of
CC ribosome biogenesis. {ECO:0000256|HAMAP-Rule:MF_00195,
CC ECO:0000256|RuleBase:RU004481}.
CC -!- SUBUNIT: Associates with the 50S ribosomal subunit. {ECO:0000256|HAMAP-
CC Rule:MF_00195}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. EngA (Der) GTPase family.
CC {ECO:0000256|ARBA:ARBA00008279, ECO:0000256|HAMAP-Rule:MF_00195,
CC ECO:0000256|PROSITE-ProRule:PRU01049, ECO:0000256|RuleBase:RU004481}.
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DR EMBL; CP003015; AEU09388.1; -; Genomic_DNA.
DR RefSeq; WP_014246276.1; NC_016621.1.
DR AlphaFoldDB; G8LS15; -.
DR STRING; 1075399.BLBCPU_345; -.
DR KEGG; bcp:BLBCPU_345; -.
DR eggNOG; COG1160; Bacteria.
DR HOGENOM; CLU_016077_6_2_10; -.
DR Proteomes; UP000007112; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR CDD; cd01894; EngA1; 1.
DR CDD; cd01895; EngA2; 1.
DR Gene3D; 3.30.300.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_00195; GTPase_Der; 1.
DR InterPro; IPR031166; G_ENGA.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR016484; GTPase_Der.
DR InterPro; IPR032859; KH_dom-like.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR NCBIfam; TIGR03594; GTPase_EngA; 1.
DR NCBIfam; TIGR00231; small_GTP; 2.
DR PANTHER; PTHR43834; GTPASE DER; 1.
DR PANTHER; PTHR43834:SF6; GTPASE DER; 1.
DR Pfam; PF14714; KH_dom-like; 1.
DR Pfam; PF01926; MMR_HSR1; 2.
DR PIRSF; PIRSF006485; GTP-binding_EngA; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51712; G_ENGA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|HAMAP-
KW Rule:MF_00195};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00195};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU004481};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517, ECO:0000256|HAMAP-
KW Rule:MF_00195}.
FT DOMAIN 3..169
FT /note="EngA-type G"
FT /evidence="ECO:0000259|PROSITE:PS51712"
FT BINDING 9..16
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00195"
FT BINDING 56..60
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00195"
FT BINDING 121..124
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00195"
FT BINDING 186..193
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00195"
FT BINDING 233..237
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00195"
FT BINDING 298..301
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00195"
SQ SEQUENCE 441 AA; 51353 MW; DD5EE6BB5DC6F089 CRC64;
MSYLVSIVGR PNVGKSTLFN RIIGKKKAIV HVKSGVTRDR IYGNSEWNGI QFSIVDTGGY
NPPNNNIDII DTEIRKQILI ALKESDVILF LVDMEIGLLD VDIEISKILR KCKKSILLVV
NKVDNGKNLY HDTDFFRLGF NNYYCISAIN GSGTGEMLDR LIEILKELVE KKVEEIGDIP
RFSVIGRPNV GKSTLINSFL DKYRHIVTNI SGTTRDSIDV FYKKFGYKCI LFDTPGVRKK
SKISENIEFY STMKTVRTIK YTDICFLMVD AVRGWESQDR NIFRLIEKNQ KGVIILINKW
DLLHNNKNCS IKKNFEIFIK KNIAPFDNVP ILFISAKNKD GLYNIIPIAY HIFRKRKKRL
KTNLLNRVMF PIFKKNPPPS INKKLITIKY CTQLPTYTPK FIFFSNYPQY IKESYKRFIE
NKIRYHFDFI GVPIQIFFRK K
//
