ID G8XZT4_PICSO Unreviewed; 1544 AA.
AC G8XZT4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Piso0_005736 protein {ECO:0000313|EMBL:CCE87193.1};
GN Name=Piso0_005736 {ECO:0000313|EMBL:CCE87193.1};
GN ORFNames=GNLVRS01_PISO0N21463g {ECO:0000313|EMBL:CCE87193.1};
OS Pichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC
OS 10061 / NRRL Y-12695) (Hybrid yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Millerozyma.
OX NCBI_TaxID=559304 {ECO:0000313|EMBL:CCE87193.1, ECO:0000313|Proteomes:UP000005222};
RN [1] {ECO:0000313|Proteomes:UP000005222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL
RC Y-12695 {ECO:0000313|Proteomes:UP000005222};
RX DOI=10.1534/g3.111.000745;
RA Leh Louis V., Despons L., Friedrich A., Martin T., Durrens P.,
RA Casaregola S., Neuveglise C., Fairhead C., Marck C., Cruz J.A.,
RA Straub M.L., Kugler V., Sacerdot C., Uzunov Z., Thierry A., Weiss S.,
RA Bleykasten C., De Montigny J., Jacques N., Jung P., Lemaire M., Mallet S.,
RA Morel G., Richard G.F., Sarkar A., Savel G., Schacherer J., Seret M.L.,
RA Talla E., Samson G., Jubin C., Poulain J., Vacherie B., Barbe V.,
RA Pelletier E., Sherman D.J., Westhof E., Weissenbach J., Baret P.V.,
RA Wincker P., Gaillardin C., Dujon B., Souciet J.L.;
RT "Pichia sorbitophila, an interspecies yeast hybrid reveals early steps of
RT genome resolution following polyploidization.";
RL G3 (Bethesda) 2:299-311(2012).
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DR EMBL; FO082046; CCE87193.1; -; Genomic_DNA.
DR STRING; 559304.G8XZT4; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_1_1; -.
DR InParanoid; G8XZT4; -.
DR OMA; WIANQID; -.
DR Proteomes; UP000005222; Chromosome N.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005222};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1544
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003518486"
FT TRANSMEM 1374..1392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..698
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 735..1358
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT REGION 1499..1544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1516..1544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1544 AA; 173527 MW; 1D50DD3058565D68 CRC64;
MRQLALLHLF FVFLLNISNG GVLANEFTPS IKVHRLFNTT ADYAYFDDSR TILSSRNKKL
YISNNDGVDW NIVKEAENED IFTIVIDDMH KDRAIAFGDG NTHFITNNGG KDWKSFRFDL
NVEDESSELR SFSGLVQHAT NRNLAMIKFE KCSTSKSHGP QCKKYHFYTE DNFKSDPKLL
DIEDGSCIFA KSSKEFEGGE EKTIYCSLNR RNSLGHVIGS TFIESTNFLQ SKKMIKIDIA
PSSKILDIYV KSSFLIIIYQ NDKYNENSRV TLVVSKDGKI FNKADLKVDI AFGVMAFLDA
SPSSIFVEVI DYSNPFAFYS RSAIFSSDSQ GLSFTKILDN VKDNIITKVQ TIDGVWIANV
IDEEKTAEGK AHRSGLFNGM NNRGVSMMSF DNGGTWQRLE ISDDKNCKVQ DGCSLHVIGL
KEQTGEGKFV TGPTPGILLA IGVKGKGIEY SDSLHTWISR DGGLTWQLAL DEPCAYSFGD
QGNIIVAVPY THSEKSKSTK VYYSIDQGKS WSHFELEVPI YPITLTTTVD GTSTKFILSG
LDAENSSIEK RLFSEALYAI NFENAFGGVK CDLKKDFEEF YARKTPEDKP VCVYGHKERF
LRRKQDAKCF VNRLFENVKI YDEPCECTVK DFECAPGYVK NNEECVPNGK SILKICDKNK
KDKVTLPDKK LIGGNSCKNS NSVANKIIKT NTFDCNELKH EPGAHGADIA VSNFEVASPI
SQFTYIESGR TYIGENILVK SKDGSIYASN NGGISFVKVA VPEKVVDIYT GFQPGQAILV
TNTEMFYYSS DGGNMFIRQA APVPINSLGA KGLIFHRSDP ARFIWLGNGN CDANKFCTLM
AYITLDEGRT FRKLKADVTT CDFVSPVFKN ERPEDEIFCT EFDKTSNTLK LTSSENYFDN
QKVLFDDIIG YAITGHFLFV ATLDENKKSL KAKITEDGSV FADSKFPANF KIEVEEAYTI
LDSDTGSIFM HITTSSEHGL EVGAVLKSNS NGTSYVLSLD NVNRNSAGYV DFNRVDGLEG
VILSNTVDFV GKEKKLKTQI THNDGAEWAY IPPPKYDSKG KRYSCDVNKL GECSLNLHGF
TEKLTYEDSF SSPTAIGFLM GVGNVGKYLD DAEKASLFLS KDGGISWREV MKGNYVWQYA
DRGTIIVVVK RGEPTKKFYF SLDDGETFIE YEFSDKPIRV LDLSSVPSEV SRKLLIFGEG
DSKSEIYSID FSNVYERQCQ LDLDNPDGDD FEYWSPKHPL LPDNCLFGHE SKYLRRAEGH
YDCFIGSAPL IDGFKVTKNC SCTRRDYECD YNYFRDKDGT CKLIRGLTPI DYKEATCKKK
NEIEYFEPSG YRKIPLSTCH AGLELDSWDP KPCPGKLKQF KKKHSIKMST FTKISLIYLP
ILVFVLVIWF VYDRGIRRNG GFKRFGQIRL DVDEDDFHPI EDNNLDKVVN KIVKGGVIVA
ASVFAGIKAV SKFDRGILDK LSGKIFGRSP GRRRYVRVPG IDEEEELFGD LDEDAIENFD
DMDTFPGEDT NNNQVDDQEV DERLFNLDDE SSDGNHTDSR TPDS
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