ID G8YM02_PICSO Unreviewed; 435 AA.
AC G8YM02;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Peroxisome assembly protein 12 {ECO:0000256|ARBA:ARBA00018980};
DE AltName: Full=Peroxin-12 {ECO:0000256|ARBA:ARBA00029692};
GN Name=Piso0_001903 {ECO:0000313|EMBL:CCE88398.1};
GN ORFNames=GNLVRS01_PISO0F00423g {ECO:0000313|EMBL:CCE88398.1};
OS Pichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC
OS 10061 / NRRL Y-12695) (Hybrid yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Millerozyma.
OX NCBI_TaxID=559304 {ECO:0000313|EMBL:CCE88398.1, ECO:0000313|Proteomes:UP000005222};
RN [1] {ECO:0000313|Proteomes:UP000005222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL
RC Y-12695 {ECO:0000313|Proteomes:UP000005222};
RX DOI=10.1534/g3.111.000745;
RA Leh Louis V., Despons L., Friedrich A., Martin T., Durrens P.,
RA Casaregola S., Neuveglise C., Fairhead C., Marck C., Cruz J.A.,
RA Straub M.L., Kugler V., Sacerdot C., Uzunov Z., Thierry A., Weiss S.,
RA Bleykasten C., De Montigny J., Jacques N., Jung P., Lemaire M., Mallet S.,
RA Morel G., Richard G.F., Sarkar A., Savel G., Schacherer J., Seret M.L.,
RA Talla E., Samson G., Jubin C., Poulain J., Vacherie B., Barbe V.,
RA Pelletier E., Sherman D.J., Westhof E., Weissenbach J., Baret P.V.,
RA Wincker P., Gaillardin C., Dujon B., Souciet J.L.;
RT "Pichia sorbitophila, an interspecies yeast hybrid reveals early steps of
RT genome resolution following polyploidization.";
RL G3 (Bethesda) 2:299-311(2012).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBUNIT: Component of the PEX2-PEX10-PEX12 retrotranslocation channel,
CC composed of PEX2, PEX10 and PEX12. {ECO:0000256|ARBA:ARBA00034505}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Peroxisome
CC membrane {ECO:0000256|ARBA:ARBA00004585}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004585}.
CC -!- SIMILARITY: Belongs to the pex2/pex10/pex12 family.
CC {ECO:0000256|ARBA:ARBA00008704}.
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DR EMBL; FO082054; CCE88398.1; -; Genomic_DNA.
DR AlphaFoldDB; G8YM02; -.
DR STRING; 559304.G8YM02; -.
DR eggNOG; KOG0826; Eukaryota.
DR HOGENOM; CLU_031067_0_0_1; -.
DR InParanoid; G8YM02; -.
DR OMA; RCPITGY; -.
DR Proteomes; UP000005222; Chromosome F.
DR GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016562; P:protein import into peroxisome matrix, receptor recycling; IEA:UniProt.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProt.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR017375; PEX12.
DR InterPro; IPR006845; Pex_N.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12888:SF0; PEROXISOME ASSEMBLY PROTEIN 12; 1.
DR PANTHER; PTHR12888; PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12; 1.
DR Pfam; PF04757; Pex2_Pex12; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR PIRSF; PIRSF038074; Peroxisome_assembly_p12; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000005222};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 335..409
FT /note="RING-type"
FT /evidence="ECO:0000259|SMART:SM00184"
SQ SEQUENCE 435 AA; 50726 MW; C3FBA539337E3E3D CRC64;
MEYYSSLDSS QLNADVPTLF EIISSNQLES LLSPSLRYVL VHYANRFPHL LLKVVNNFDE
LNLFLRTFVE WYFIKYWQGS FTENFYGLKR VSHTPLAEEK YQTKKVSELI PSLIEERRKL
SSIQVLASVF EITGTAYLTE KFNYWYDIWY PMYITKQLET NKDDVWKKKV KLKAKIFFVK
YYPLVLGAFR AGNLISTLSF LGGKSYSPSL ITLLFRINYA RLNQYDYSSH DHKIKDKRNH
KNRVSPPSNL SIVIRILQRY FAMPSWKVIK LLLGTFFPAA IFTLKFLEWY NNTNFAQKIA
QTQGNTLKSI LPTPSSILKY DSRKKKKGYQ SSEDCPLCKE KISNPAVIET GYVFCYSCIY
DYLSKSHKIV AATRNLKTND DENKTDENIA SEQEQSHIDL ELGGRCPITG KKLLGCRWNT
LKGEWEIEGI RRLIL
//
