ID G9BBX0_PARLI Unreviewed; 570 AA.
AC G9BBX0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 08-NOV-2023, entry version 40.
DE SubName: Full=Frizzled7 {ECO:0000313|EMBL:AEO92034.1};
OS Paracentrotus lividus (Common sea urchin).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC Euechinoidea; Echinacea; Camarodonta; Echinidea; Echinidae; Paracentrotus.
OX NCBI_TaxID=7656 {ECO:0000313|EMBL:AEO92034.1};
RN [1] {ECO:0000313|EMBL:AEO92034.1}
RP NUCLEOTIDE SEQUENCE.
RA Croce J., Lhomond G.;
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEO92034.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22274701; DOI=10.1242/dev.072215;
RA Lhomond G., McClay D.R., Gache C., Croce J.C.;
RT "Frizzled1/2/7 signaling directs beta-catenin nuclearisation and initiates
RT endoderm specification in macromeres during sea urchin embryogenesis.";
RL Development 139:816-825(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR EMBL; HQ322502; AEO92034.1; -; mRNA.
DR AlphaFoldDB; G9BBX0; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15034; 7tmF_FZD1_2_7-like; 1.
DR CDD; cd07458; CRD_FZ1_like; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF47; FRIZZLED; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..570
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003519731"
FT TRANSMEM 226..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..154
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 224..548
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT DISULFID 43..104
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 51..97
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 118..142
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 570 AA; 64539 MW; BCB24C4506E42E90 CRC64;
MGWMKGEKRH LAGGFLLTLM VVFFGSANAQ LADYNEGITH GRCEAITIPL CEDMPYNMTI
MPNLLNHQHQ EDAGLEVHQF YPLVKVQCSE DLKNFLCSMY APVCTLLESA LPPCKSLCLS
ARNGCESLMN KFGFSWPASL SCDQFPEGGL CFDRNRTEER VTIPSTKTPN ITKPTEPSVT
KDIPFTCPLQ LTVDHDWDYS FMRAQNCGAP CNMYFHTEKE QKFARYWVGC WAFVCAVSSL
FTVLTFLIDR SRFRYPERPI IFLSGCYFVI SVVFIAGFFL EDRVSCNKPY LPGGGSTLVQ
GAKQQWCTIL FMLLYFFQMA SCLWWVVLSL TWFLAAGLKW GHEAIERNSQ YFHFAAWSIP
AGKTIGVLAT GQVDGDSLSG VCYTGIRDMN ALRGFILAPL FVYLIIGSLF LCAGFIALFR
IRTFMKSDGN KTDKLEKLMI RIGIFSLLYT VPATIVIGCY IYEQANREVW EWFWLLGNCH
RYSFACPQNL PSWVSIESLQ ESLSFLGARQ SLNLPGPDYL VFIVKYLMML IVGITSSVWV
WSGKTLRSWT QFYSRLCNLS SHPKGAPANV
//
