ID G9FK57_9SAUR Unreviewed; 693 AA.
AC G9FK57;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Transient receptor potential cation channel subfamily V member 1 {ECO:0000256|ARBA:ARBA00015942};
DE AltName: Full=Osm-9-like TRP channel 1 {ECO:0000256|ARBA:ARBA00033256};
DE AltName: Full=Vanilloid receptor 1 {ECO:0000256|ARBA:ARBA00031766};
DE Flags: Fragment;
GN Name=TRPV1 {ECO:0000313|EMBL:AEW26684.1};
OS Pseudoxenodon macrops.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Colubridae; Pseudoxenodontinae; Pseudoxenodon.
OX NCBI_TaxID=1082482 {ECO:0000313|EMBL:AEW26684.1};
RN [1] {ECO:0000313|EMBL:AEW26684.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DYXLS {ECO:0000313|EMBL:AEW26684.1};
RX PubMed=22163322; DOI=10.1371/journal.pone.0028644;
RA Geng J., Liang D., Jiang K., Zhang P.;
RT "Molecular Evolution of the Infrared Sensory Gene TRPA1 in Snakes and
RT Implications for Functional Studies.";
RL PLoS ONE 6:E28644-E28644(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cell
CC projection, dendritic spine membrane {ECO:0000256|ARBA:ARBA00004332};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004332}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. TrpV
CC subfamily. TRPV1 sub-subfamily. {ECO:0000256|ARBA:ARBA00010374}.
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DR EMBL; JN164352; AEW26684.1; -; mRNA.
DR AlphaFoldDB; G9FK57; -.
DR GO; GO:0032591; C:dendritic spine membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR024862; TRPV.
DR InterPro; IPR008347; TrpV1-4.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10582:SF17; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 1; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01768; TRPVRECEPTOR.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 2: Evidence at transcript level;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Receptor {ECO:0000313|EMBL:AEW26684.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 369..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 475..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 515..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 594..617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 137..169
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 422..629
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEW26684.1"
FT NON_TER 693
FT /evidence="ECO:0000313|EMBL:AEW26684.1"
SQ SEQUENCE 693 AA; 79716 MW; 341A47F46A6317E0 CRC64;
SFYHMEQLDS NPIIKFSFRL ERGRCGNHCP KLLSTASIGV CAGKAFKIYD RRSLFDAVAQ
GDPSQLDDLL IYLLESLKTL TDAEFKEPDT GKTCLLKAML NLHNGRNDTI PLLLEIAEKT
ESLQEFVNAG YTDGYYKGQT ALHIAIERRN MYLVNLLVKN GADVHARAHG EFFQKIEGKP
GFYFGELPLS LAACTNQLNI VKFLLENPYQ PANIAEQDSM GNTILHALVE IADDTDDNTK
FVTKMYNDVL ILGASINPTL RLEELTNRRG LTPLTLAAKT GKIQVFAYIL RREMKEPECR
HLSRKFTEWA YGPVHSSLYD LSSIDTCEKN SVLEIIAYSS ETPNRHEMLL VEPLNQLLQD
KWDRFVKHLF YFNFFIYTVH TLILTVAAYY RPTKKEGTPP FTFHHRRGEY FRVTGEILSV
LGGAYFFFRG IKYFQQRRPS LKAIFTECYS ELLFFVHSVL LLGSAVLYFS KQEVYVVLMV
FALALGWSNL IYYTRGFQQM GIYSVMLEKM MLRDLGRFIM VYLLFHLGFS TAVVTLIEED
NEGRPETPPP QVCPCPVKAR PSYNNLYTTC LELFKFTIGM GDLEFTENYR FKSVFIILLL
IYVVLTYILL LNMLIALMGE TVNKIAQESK SIWKLQRTIT ILNIENSYWN CIINSFRSGK
RVLVGTTPDG KEDYRWCFRV DEVNWSTWNT NLS
//
