ID G9FWX8_9HIV1 Unreviewed; 339 AA.
AC G9FWX8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:AET86661.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AET86661.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AET86661.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AET86661.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HNTR20 {ECO:0000313|EMBL:AET86661.1};
RX PubMed=22493752;
RA Diallo K., Murillo W.E., de Rivera I.L., Albert J., Zhou Z., Nkengasong J.,
RA Zhang G., Sabatier J.F., Yang C.;
RT "Comparison of HIV-1 resistance profiles in plasma RNA versus PBMC DNA in
RT heavily treated patients in Honduras, a resource-limited country.";
RL Int J Mol Epidemiol Genet 3:56-65(2012).
CC -!- SIMILARITY: Belongs to the retroviral Pol polyprotein family.
CC {ECO:0000256|RuleBase:RU004064}.
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DR EMBL; JN215220; AET86661.1; -; Genomic_RNA.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001995; Peptidase_A2_cat.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR018061; Retropepsins.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00077; RVP; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50175; ASP_PROT_RETROV; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750,
KW ECO:0000256|RuleBase:RU004064};
KW DNA integration {ECO:0000256|ARBA:ARBA00023195};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004064};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|RuleBase:RU004064};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW Virion maturation {ECO:0000256|ARBA:ARBA00023113};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023195};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 8..77
FT /note="Peptidase A2"
FT /evidence="ECO:0000259|PROSITE:PS50175"
FT DOMAIN 131..321
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT UNSURE 81
FT /note="I or L"
FT /evidence="ECO:0000313|EMBL:AET86661.1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AET86661.1"
FT NON_TER 339
FT /evidence="ECO:0000313|EMBL:AET86661.1"
SQ SEQUENCE 339 AA; 38792 MW; C70F53E87E5FA0CD CRC64;
XKIGGQIKEA LLDTGADDTV LEEMNLPGRW KPXMIGGIGG FIKVRQYDQI PIXICGHKXE
GXVLXGPTPV NIIGRBLLTQ XGCTLNFPIS PIETVPVKLK PGMDGPKVKQ WPLTEEKIKA
LXEICXEXEK EGKISKIGPE NPYNTPVFAI KKKDGNKWRK XVDFRELNKR TQDFWEVQLG
IPHPAGLXKK KSVTVLDVGD AYFSVPLDXD FRKYTAFTIP SINNETPGIR YQYNVLPQGW
KGSPAIFQXS MTKILEPFRK QNPDIVIXQY XDDLYVXSDL EIEQHRTKIE ELRQHLLRWG
FYTPDKKHQK EPPFLWMGYE LHPDKWTVQP IMLPEKGSW
//
