ID   G9I8W5_CRYNV            Unreviewed;       372 AA.
AC   G9I8W5;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Apoptosis-inducing factor {ECO:0000313|EMBL:AEV23666.1};
GN   Name=Aif1 {ECO:0000313|EMBL:AEV23666.1};
OS   Cryptococcus neoformans var. grubii (Filobasidiella neoformans var.
OS   grubii).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=178876 {ECO:0000313|EMBL:AEV23666.1};
RN   [1] {ECO:0000313|EMBL:AEV23666.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=RCT 17 {ECO:0000313|EMBL:AEV23666.1};
RX   PubMed=22114551; DOI=10.1371/journal.ppat.1002364;
RA   Semighini C.P., Averette A.F., Perfect J.R., Heitman J.;
RT   "Deletion of Cryptococcus neoformans AIF Ortholog Promotes Chromosome
RT   Aneuploidy and Fluconazole-Resistance in a Metacaspase-Independent
RT   Manner.";
RL   PLoS Pathog. 7:E1002364-E1002364(2011).
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DR   EMBL; JN606083; AEV23666.1; -; Genomic_DNA.
DR   AlphaFoldDB; G9I8W5; -.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:UniProt.
DR   Gene3D; 3.50.50.100; -; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   PANTHER; PTHR43735; APOPTOSIS-INDUCING FACTOR 1; 1.
DR   PANTHER; PTHR43735:SF11; HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG); 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   PRINTS; PR00368; FADPNR.
DR   PRINTS; PR00411; PNDRDTASEI.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   4: Predicted;
FT   DOMAIN          7..313
FT                   /note="FAD/NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF07992"
SQ   SEQUENCE   372 AA;  40497 MW;  D45DCF74F88F6614 CRC64;
     MSSAIRNVIV VGGSYVGSKA AQELAVILPP THRVLLVEPH SHFHHLFAFP RFAVVPTYEH
     KAFIPFTSIF NEPAIPNPSL HAVVRAKVNA VYPTHVSLDR AWRGETDIPY DFLAIATGTK
     LPAPGSMQSE DKSNSVEYFK TYQEGVKRAK DIVIIGGGAV GVQMACDIKE VSPEKNVTLV
     QSRDHVMPKF HSKLHEIISN RFKELGVNLV TNNRVSVPAE GFPNDGSTFS VVLKDGTSIP
     AQLVIPATGQ IPNTQLLSTL PPFSTDSLIN PANGFISVRP TLQLQDTKYS NIFAVGDIAD
     SGAHKAARPA MQHAKVLARN IVAMIDGKQP DEKINVEPAA IHMTMGLVQN IVFRNPNTAG
     GDTEPSYRFR DE
//