ID G9J1P1_EQUGR Unreviewed; 843 AA.
AC G9J1P1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Toll-like receptor 4 {ECO:0000256|ARBA:ARBA00040109};
GN Name=TLR4 {ECO:0000313|EMBL:AEX01205.1};
OS Equus grevyi (Grevy's zebra).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9792 {ECO:0000313|EMBL:AEX01205.1};
RN [1] {ECO:0000313|EMBL:AEX01205.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=14 {ECO:0000313|EMBL:AEX01205.1};
RA Frolkova P., Bayerlova M., Martinkova N., Vokata B., Vychodilova L.,
RA Horin P.;
RT "Genetic diversity, evolution and selection of the TLR4 gene in the family
RT Equidae.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle
CC {ECO:0000256|ARBA:ARBA00004466}. Early endosome
CC {ECO:0000256|ARBA:ARBA00004412}. Endosome
CC {ECO:0000256|ARBA:ARBA00004177}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
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DR EMBL; JN797513; AEX01205.1; -; Genomic_DNA.
DR AlphaFoldDB; G9J1P1; -.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF521; TOLL-LIKE RECEPTOR 4; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 6.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52047; RNI-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..843
FT /note="Toll-like receptor 4"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011111221"
FT TRANSMEM 635..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 674..817
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 824..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 96388 MW; EF7FD52D39F0B257 CRC64;
MMPPTRLAGT LIPAMAFLSC LRPESWDPCV QVVPNTTYQC MDLNLYKIPE NIPTSTKELD
LSFNPLKELG SHSFSNFPEL QVLDLSRCEI EMIEDDAYQG LNHLSTLILT GNPIRSLALG
AFSGLSSLQT LVAVETKLSS LEKFPIGHLK TLKELNVAHN LIHSFKLPEY FSKMPNLEHL
DLSNNKIQNI SHEDLRVLHQ TPLLNLSLDL SLNPLEFIQP DAFKEIKLHK LTLRSNFDSI
DVMKSCIQGL AGLKVNRLVL GEFKNERKLE RFDTSALRGL HNLTIEEFRL AYIDNYSSKD
SIDLLNCLAN ISKISLVSLD LGNLKDFPKG FGWQDFELVN CRIEGFPTLE LTSLKRLVFT
SNKDMKSFNE VKLPSLEFLD LSRNRLSFKS CCSEADLKTT RLKHLDLSFN DVISMSSNFM
GLEQLEHLDF QHSTLKQASD FPVFLSLKNL RYLDISYTNT RVVFHGIFDG LVSLQVLKMA
GNSFKDNFLP NVFREMTNLT TLDLSKCNLE QVSQEAFCLL PRLRVLNMSH NNLLFLDTLP
YKPLHSLQIL DCSFNRIVAF KWQELQHFPS SLASLNLTQN DFACVCEYQS FLQWVKDQRQ
LLVEVEHLVC AIPLQMRGMP VLGFNNATCQ ISKTIVGGSV FSILVVSVIA VLVYKFYFHL
MLLAGCKKYG RGESIYDAFV IYSSQDEDWV RNELVKNLEE GVPPFQLCLH YRDFIPGVAI
AANIIQEGFH KSRKVIVVVS QHFIQSRWCI FEYEIAQTWQ FLSSRAGIIF IVLHKLEKSL
LRQQVELYRL LNRNTYLEWE DSVLGRHIFW RRLRKALLDG KPWSPAGTAD AAESRQHDAE
TST
//
