ID G9JZK6_BUBBU Unreviewed; 321 AA.
AC G9JZK6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Sex determining region Y-box 2 {ECO:0000313|EMBL:AEW23225.1};
GN Name=Sox2 {ECO:0000313|EMBL:AEW23225.1};
OS Bubalus bubalis (Domestic water buffalo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bubalus.
OX NCBI_TaxID=89462 {ECO:0000313|EMBL:AEW23225.1};
RN [1] {ECO:0000313|EMBL:AEW23225.1}
RP NUCLEOTIDE SEQUENCE.
RA Shi D., Deng Y., Liu Q.;
RT "Generation of induced pluripotent stem cell from buffalo (Bubalus bubalis)
RT fetal fibroblasts with buffalo-derived defined factors.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; JN986576; AEW23225.1; -; mRNA.
DR AlphaFoldDB; G9JZK6; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd01388; HMG-box_SoxB; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR022097; SOX_fam.
DR PANTHER; PTHR10270; SOX TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR10270:SF231; TRANSCRIPTION FACTOR SOX-2; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12336; SOXp; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 45..113
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 45..113
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 321 AA; 34585 MW; F21216E89A5CD1FA CRC64;
MYNMMETELK PPGPQQTPGG GGGGGGGNST AAAAGGNQKN SPDRVKRPMN AFMVWSRGQR
RKMAQENPKM HNSEISKRLG AEWKLLSETE KRPFIDEAKR LRALHMKEHP DYKYRPRRKT
KTLMKKDKYT LPGGLLAPGG NSMPSGVGVG AGLGAGVNQR MDSYAHMNGW SNGSYSMMQD
QLGYPQHPGL NAHGAAQMQP MHRYDVSALQ YNSMTSSQTY MNGSPTYSMS YSQQGTPGMA
LGSMGSVVKS EASSSPPVVT SSSHSRAPCQ AGDLRDMINM YLPGAEVPEP AAPSRLHMSQ
HYQSGPVPGT AINGTPPLSH M
//
