ID G9K5B7_MUSPF Unreviewed; 539 AA.
AC G9K5B7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
DE Flags: Fragment;
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|EMBL:AES00092.1};
RN [1] {ECO:0000313|EMBL:AES00092.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Lungs {ECO:0000313|EMBL:AES00092.1};
RX PubMed=23236062; DOI=10.1128/JVI.02476-12;
RA Leon A.J., Banner D., Xu L., Ran L., Peng Z., Yi K., Chen C., Xu F.,
RA Huang J., Zhao Z., Lin Z., Huang S.H., Fang Y., Kelvin A.A., Ross T.M.,
RA Farooqui A., Kelvin D.J.;
RT "Sequencing, annotation, and characterization of the influenza ferret
RT infectome.";
RL J. Virol. 87:1957-1966(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; JP011494; AES00092.1; -; mRNA.
DR AlphaFoldDB; G9K5B7; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00064; FU; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR PANTHER; PTHR21662:SF19; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR PANTHER; PTHR21662; UNCHARACTERIZED; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR SMART; SM00261; FU; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000313|EMBL:AES00092.1}; Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..39
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 40..539
FT /note="receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003522897"
FT DOMAIN 60..169
FT /note="Receptor L-domain"
FT /evidence="ECO:0000259|Pfam:PF01030"
FT DOMAIN 185..342
FT /note="Furin-like cysteine-rich"
FT /evidence="ECO:0000259|Pfam:PF00757"
FT DOMAIN 361..471
FT /note="Receptor L-domain"
FT /evidence="ECO:0000259|Pfam:PF01030"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AES00092.1"
FT NON_TER 539
FT /evidence="ECO:0000313|EMBL:AES00092.1"
SQ SEQUENCE 539 AA; 61096 MW; 45C1C8C288F33283 CRC64;
KGISSQIKGM KSGSGGGSPT SLWGLLFFSA ALSLWPTSGE ICGPGIDIRN DYQQLKRLEN
CTVIEGYLHI LLISKAEDYR SYRFPKLTVI TEYLLLFRVA GLESLGDLFP NLTVIRGWKL
FYNYALVIFE MTNLKDIGLY NLRNITRGAI RIEKNADLCY LSTVDWSLIL DAVSNNYIVG
NKPPKECGDL CPGTMEEKPL CEKTTINNEY NYRCWTTNRC QKMCPSACGK RACTENNECC
HPECLGSCSA PDNDTACVAC KHYYYSGVCV PTCPPNTYRF EGWRCVDRDF CANIPNAESS
DSEGFVIHNG ECMQECPSGF IRNGSQSMYC IPCEGPCPKV CEEEKKTKTI DSVTSAQMLQ
GCTIFKGNLL INIRRGNNIA SELENFMGLI EVVTGYVKIR HSHALVSLSF LKNLRQILGE
EQLEGNYSFY VLDNQNLQQL WDWDHRNLTI KAGKMYFAFN PKLCVSEIYR MEEVTGTKGR
QSKGDINTRN NGERASCESD VLHFTSTTTW KNRIIITWHR YRPPDYRDLI SFTVYYKEA
//
