ID G9KG27_MUSPF Unreviewed; 380 AA.
AC G9KG27;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Peroxisomal membrane protein PEX14 {ECO:0000256|ARBA:ARBA00029502, ECO:0000256|RuleBase:RU367032};
DE AltName: Full=Peroxin-14 {ECO:0000256|ARBA:ARBA00029691, ECO:0000256|RuleBase:RU367032};
DE Flags: Fragment;
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|EMBL:AES03852.1};
RN [1] {ECO:0000313|EMBL:AES03852.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Lungs {ECO:0000313|EMBL:AES03852.1};
RX PubMed=23236062; DOI=10.1128/JVI.02476-12;
RA Leon A.J., Banner D., Xu L., Ran L., Peng Z., Yi K., Chen C., Xu F.,
RA Huang J., Zhao Z., Lin Z., Huang S.H., Fang Y., Kelvin A.A., Ross T.M.,
RA Farooqui A., Kelvin D.J.;
RT "Sequencing, annotation, and characterization of the influenza ferret
RT infectome.";
RL J. Virol. 87:1957-1966(2013).
CC -!- FUNCTION: Component of the PEX13-PEX14 docking complex, a translocon
CC channel that specifically mediates the import of peroxisomal cargo
CC proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms
CC a large import pore which can be opened to a diameter of about 9 nm.
CC Mechanistically, PEX5 receptor along with cargo proteins associates
CC with the PEX14 subunit of the PEX13-PEX14 docking complex in the
CC cytosol, leading to the insertion of the receptor into the organelle
CC membrane with the concomitant translocation of the cargo into the
CC peroxisome matrix. {ECO:0000256|RuleBase:RU367032}.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane
CC {ECO:0000256|RuleBase:RU367032}.
CC -!- SIMILARITY: Belongs to the peroxin-14 family.
CC {ECO:0000256|ARBA:ARBA00005443, ECO:0000256|RuleBase:RU367032}.
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DR EMBL; JP015254; AES03852.1; -; mRNA.
DR AlphaFoldDB; G9KG27; -.
DR GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016560; P:protein import into peroxisome matrix, docking; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR025655; PEX14.
DR InterPro; IPR006785; Pex14_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23058; PEROXISOMAL MEMBRANE PROTEIN PEX14; 1.
DR PANTHER; PTHR23058:SF0; PEROXISOMAL MEMBRANE PROTEIN PEX14; 1.
DR Pfam; PF04695; Pex14_N; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367032};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140, ECO:0000256|RuleBase:RU367032};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU367032};
KW Translocation {ECO:0000256|ARBA:ARBA00023010};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367032}.
FT DOMAIN 24..67
FT /note="Peroxisome membrane anchor protein Pex14p N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF04695"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 66..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 177..204
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..340
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..380
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AES03852.1"
FT NON_TER 380
FT /evidence="ECO:0000313|EMBL:AES03852.1"
SQ SEQUENCE 380 AA; 41576 MW; 49BCF13BE27CB07D CRC64;
ASSEQAEQPS QPSSTPGSEN VVPREPLIAT AVKFLQNSRV RQSPLATRRA FLKKKGLTDE
EIDLAFQQSG TVPSSSRARP ADEPPSLGPA TQVVPVQPPH LISQPYSPVG SRWRDYGALA
VITAGIAFGF HQLYKRYLLP LIMGGREDRK HLERMEASLS ELSGSVAQTV TQLQMTLASV
QELLIQQQQK VQELAHELAA AKATTSTNWI LESQNINELK SEINSLKGLL LNRRQFPPSP
SAPKIPSWQI PVKTPSPSSP AAANHHSSSD ISPVSNESTS SSPVKEGHSP EGSTATYHLL
GAQEEGQGVV DVKGQVRMEV QGEEEEREDE EDEEDEDASR VDEEHCLGVQ REDRRGGDGQ
INEQVEKLRR PEGASNENER
//
