ID G9LPS4_BOMMO Unreviewed; 515 AA.
AC G9LPS4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059};
DE EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059};
GN Name=UGT33D3 {ECO:0000313|EMBL:AEW43147.1};
GN Synonyms=100862803 {ECO:0000313|EnsemblMetazoa:NP_001243956.1};
OS Bombyx mori (Silk moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Bombycidae; Bombycinae; Bombyx.
OX NCBI_TaxID=7091 {ECO:0000313|EMBL:AEW43147.1};
RN [1] {ECO:0000313|Proteomes:UP000005204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=p50T {ECO:0000313|Proteomes:UP000005204};
RX PubMed=19121390; DOI=10.1016/j.ibmb.2008.11.004;
RG International Silkworm Genome Consortium;
RT "The genome of a lepidopteran model insect, the silkworm Bombyx mori.";
RL Insect Biochem. Mol. Biol. 38:1036-1045(2008).
RN [2] {ECO:0000313|EMBL:AEW43147.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22155036; DOI=10.1016/j.ibmb.2011.11.006;
RA Ahn S.J., Vogel H., Heckel D.G.;
RT "Comparative analysis of the UDP-glycosyltransferase multigene family in
RT insects.";
RL Insect Biochem. Mol. Biol. 42:133-147(2012).
RN [3] {ECO:0000313|EnsemblMetazoa:NP_001243956.1}
RP IDENTIFICATION.
RC STRAIN=p50T (Dazao) {ECO:0000313|EnsemblMetazoa:NP_001243956.1};
RG EnsemblMetazoa;
RL Submitted (JUN-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC Evidence={ECO:0000256|RuleBase:RU362059};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362059}; Single-
CC pass membrane protein {ECO:0000256|RuleBase:RU362059}.
CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}.
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DR EMBL; JQ070231; AEW43147.1; -; mRNA.
DR RefSeq; NP_001243956.1; NM_001257027.1.
DR AlphaFoldDB; G9LPS4; -.
DR EnsemblMetazoa; NM_001257027.1; NP_001243956.1; GeneID_100862803.
DR GeneID; 100862803; -.
DR KEGG; bmor:100862803; -.
DR CTD; 100862803; -.
DR HOGENOM; CLU_012949_0_3_1; -.
DR OrthoDB; 382054at2759; -.
DR Proteomes; UP000005204; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR002213; UDP_glucos_trans.
DR InterPro; IPR035595; UDP_glycos_trans_CS.
DR PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR PANTHER; PTHR48043:SF162; UDP-GLYCOSYLTRANSFERASE FAMILY 305 MEMBER A1, ISOFORM A-RELATED; 1.
DR Pfam; PF00201; UDPGT; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR PROSITE; PS00375; UDPGT; 1.
PE 2: Evidence at transcript level;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU003718}; Membrane {ECO:0000256|RuleBase:RU362059};
KW Reference proteome {ECO:0000313|Proteomes:UP000005204};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718};
KW Transmembrane {ECO:0000256|RuleBase:RU362059};
KW Transmembrane helix {ECO:0000256|RuleBase:RU362059}.
FT TRANSMEM 480..503
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362059"
SQ SEQUENCE 515 AA; 59415 MW; AA3FA9F315CBA74F CRC64;
MEFYLLICLV SINGNEAARI LGIFPMPSIS HQVVFRSLTL ELAKRGHELV VLTTDPVFHK
GTSPGNYTEI DVHDNSYQIW RNSFLQTSKG KLQDRFEEAR LVVDVIHQLF IKQLLTDEFQ
EILRSKKKFD LVILEAMMKP ARVLCHVFNA PAVIISSLGG IGDIYDIVGA PTHPLLYPVW
IRRRLHNLSF WEKLSELYNH YTFERLWNEL EEKDNELVQS AFGINMPKLN DMVDNISLIL
LNVHPIWEHN RPVPPNLIYI GGIHQKPQKA LPSDLKTYLD SSKHGVIYIS FGTNVIPSLL
SPERIQVLIK VFSQLPYDVL WKWDKDELPG KSKNIRTSKW LPQSDLLRHP KVKLFITQGG
LQSTEEAITA GVPLIGMPML GDQWYNVELY VFHKIGVKLD MDKLSEETLR YSIQEVIGDE
SYRQNIARLR TQVYDQPQSP LERAVWWTEY VLRHGGAKHL RAAGANLSWS QYLDLELTSA
LFITFVMTIT ILSYIILYLL RILRSYNSIN KIKKS
//
