ID G9MRS4_HYPVG Unreviewed; 2210 AA.
AC G9MRS4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Putative polyketide synthase {ECO:0000313|EMBL:EHK22793.1};
GN ORFNames=TRIVIDRAFT_53926 {ECO:0000313|EMBL:EHK22793.1};
OS Hypocrea virens (strain Gv29-8 / FGSC 10586) (Gliocladium virens)
OS (Trichoderma virens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=413071 {ECO:0000313|EMBL:EHK22793.1, ECO:0000313|Proteomes:UP000007115};
RN [1] {ECO:0000313|EMBL:EHK22793.1, ECO:0000313|Proteomes:UP000007115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Gv29-8 / FGSC 10586 {ECO:0000313|Proteomes:UP000007115};
RX PubMed=21501500; DOI=10.1186/gb-2011-12-4-r40;
RA Kubicek C.P., Herrera-Estrella A., Seidl-Seiboth V., Martinez D.A.,
RA Druzhinina I.S., Thon M., Zeilinger S., Casas-Flores S., Horwitz B.A.,
RA Mukherjee P.K., Mukherjee M., Kredics L., Alcaraz L.D., Aerts A., Antal Z.,
RA Atanasova L., Cervantes-Badillo M.G., Challacombe J., Chertkov O.,
RA McCluskey K., Coulpier F., Deshpande N., von Doehren H., Ebbole D.J.,
RA Esquivel-Naranjo E.U., Fekete E., Flipphi M., Glaser F.,
RA Gomez-Rodriguez E.Y., Gruber S., Han C., Henrissat B., Hermosa R.,
RA Hernandez-Onate M., Karaffa L., Kosti I., Le Crom S., Lindquist E.,
RA Lucas S., Luebeck M., Luebeck P.S., Margeot A., Metz B., Misra M.,
RA Nevalainen H., Omann M., Packer N., Perrone G., Uresti-Rivera E.E.,
RA Salamov A., Schmoll M., Seiboth B., Shapiro H., Sukno S.,
RA Tamayo-Ramos J.A., Tisch D., Wiest A., Wilkinson H.H., Zhang M.,
RA Coutinho P.M., Kenerley C.M., Monte E., Baker S.E., Grigoriev I.V.;
RT "Comparative genome sequence analysis underscores mycoparasitism as the
RT ancestral life style of Trichoderma.";
RL Genome Biol. 12:R40.1-R40.15(2011).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHK22793.1}.
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DR EMBL; ABDF02000006; EHK22793.1; -; Genomic_DNA.
DR RefSeq; XP_013957004.1; XM_014101529.1.
DR STRING; 413071.G9MRS4; -.
DR EnsemblFungi; EHK22793; EHK22793; TRIVIDRAFT_53926.
DR GeneID; 25795379; -.
DR VEuPathDB; FungiDB:TRIVIDRAFT_53926; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_31_0_1; -.
DR InParanoid; G9MRS4; -.
DR OMA; ALDSLYW; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000007115; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF13; POLYKETIDE SYNTHASE 1; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007115};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 12..437
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2124..2201
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1266..1305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1277..1297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2210 AA; 241587 MW; 3A0570F010701DB8 CRC64;
MSSSQDSNRE RPMPIAIVGM SCRLSGGVST LDDFWTMLSR SRDGWRPIPE ERFTPKAFYH
PDPQKKGSFN NKGGYFINGD LSNFDAPFFQ ITRQEAEAMD PQQRHLLECT YEALENAGIP
KNTISGSNMG VFIGGASSDY RLGTLKEVDQ IPMYDATGNH QSIQAGRISY YFNLHGPSFS
TDTACSSGLY ALHLAVQSIR SGESDSAIVA ASSLHLQPHD MVSMSMLGLF NEHGKTFAFD
HRAKSGFARG EGTGCLILKP LHKALEDKDK IRSVIIHTGA NQDGKTTGLT NPSGEAQERL
IREVYARAGI SPEDTGYVEA HGTGTRTGDP IEANSIYRVF GAGRTKRMPL YMGSVKSNVG
HLENASGIIS VIKASMMLEK GFILPNINFE KANEAIPLDE WNIKVPTSIR PWPRNKRYIS
VNSFGFGGSN AHVVLEKVPF SLRDSPHDNQ NVTPRLFVLS AHDEGAAKRV VEKLGIYIEQ
HPEVFQKRLV RDMAYTLGER RTHLQWRIAI TASSCDELAN ALNGVGATPV VASNEPKVAF
VYTGQGAQWA GMGKELMESH PVFANTIKAC SDYLQEIGAE FSLLAELAKG EKETLVNEAH
ISQPACTAIQ IGLTKLLESW GIAPSAVIGH SSGEIGAAFA AGSINIEDAM SAAYWRGKVS
SDMRLKHPDL RGAMLAVGAG AEEVKGIIKT RGLQNVTVAC ENSPDSITAS GDEEDVDKLA
AELETRSIFK RKLRVTVAYH SAHMQLVADD YKAAIKNMKD KTTSKVEFYS SLVGRKLDSA
MSLGPSYWVD NLTKPVLFSP ALKELYEGTK PDVIIEVGPH SALEGPIKQI LKNISSQAAM
GVKYLSCLIR NQHATSTALD CAGSLFVKGH PINLRKINHP NASLRLPAVV SDFYPYPWSE
HKYWFEPRSS KQLRQKPFMR HDLLGLLEDS YSDIEPKWKN VISTDDVPWL KDHRMQSLAT
FPLAGYICMA VEAASQRAQL RDIPAEQIDG FRLREIQVSK ALILDDGAPY EMIFSLKPYA
EGTRFNSSDW DEFRISSWTS ARGWLEHCSG LVGIKKAAPI NPVSDGLLRA ASIRRQHTLG
MSCHQLPMDG FYSELESRGA GYSGVFRISP DADVKIHEQY STASLTIPNT ATVMPASFEP
ASIAPAAFVD LLFQLTFPIL GAGSGEMPSL FMPSAVKAIE ISSKFPNTPG ERVQVVAHGC
PDFTAPGPVD FFIDMWYQDA IEPVTKISGF RMTPVNGDID DGVSPRSICY KVQWESLDEV
NEKAERGAKE NCAIENGHEN GDSSGKMSAS SEANGTKSHA ISHRDGSDPL VGTLLDLLEL
RTTKRPRLID FSNLIPESGC CYICLSEIDE PLLANMTEEI FEKMQNLLVT CQSVLWVTSG
AYRFAEQPES NISQGLLRTV RSEANKAVAS LDLDPHSTLD VLDTAELILR AVKVSIATPE
DDTPVDYEFA EEGGKLMVPR VVKQEDMNLA IFHDTQATAA PPYLQPFEQP GRRLTVAVGT
YGALDSLYWK DEDETPLGPH EVEIKVACTG MNFKDVVIAM GQVASPYLGI ECSGTISRIG
SCVSCLKVGD RVCAMSLGAY STFARCPASS AATIPDDMSF EVATSIPVVY CTAYYGIMDL
ARLEYGEKIL IHAATGGVGQ AAIQLAQMVG AEIYATVGSA DKKKFLMDTY GIPETRIFYS
RDVSFGPAVR EATSSHGVDV VLNSLAGDLL RETWECLAPF GRFIELGKRD ITNNTRLEMA
KLEYNCTFSS VDLTLLAARR PKLMQRTFAS VMHLLENKTI QPIGPITPVN IQNVEGALRK
LQSGKTTGKL VVTHSGQSQV KATHPAPRSD MLERDATYLI IGGTGGLGRS ITRRMVRLGA
RHIILLSRSG KVTDDLTKLM KESRKLGASI YVVPCDVADE KSVQALVEEL QDDLPPIRGI
IHAAMVLRDV LFEKMTFEDY EAVVRSKISG AWNFHKALIN TPLQFFIVLS SVAGIVGNRG
QAHYSAANTY LDALVLHRRR KGLAAASIDL AAVEGVGYLA ENAAKMSQVM RNLSDNTVGE
AEVLALIESA MTGRVDFFCQ GQVITGLGFD NASAMPFYAS DAKFSYLRDA LLATSGDVDI
SLRSEILTIC QQLRRCTTVK EAQDVVTLGL RDKLGAILML PEEVMAARQG NTSITAFGLD
SLNAIELRNW IGKELQAHLQ VLELLTSGRV ADLAGLVLRK SRIEGVWTEK
//
