ID G9PCX3_9ACTO Unreviewed; 642 AA.
AC G9PCX3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Penicillin-binding protein transpeptidase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF0045_00252 {ECO:0000313|EMBL:EHM89587.1};
OS Actinomyces graevenitzii C83.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=435830 {ECO:0000313|EMBL:EHM89587.1, ECO:0000313|Proteomes:UP000003822};
RN [1] {ECO:0000313|EMBL:EHM89587.1, ECO:0000313|Proteomes:UP000003822}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C83 {ECO:0000313|EMBL:EHM89587.1,
RC ECO:0000313|Proteomes:UP000003822};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Ward D., Feldgarden M., Gevers D., Sibley C.D., Field T.R.,
RA Grinwis M., Eshaghurshan C.S., Surette M.G., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Actinomyces graevenitzii C83.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHM89587.1}.
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DR EMBL; ACRN01000001; EHM89587.1; -; Genomic_DNA.
DR RefSeq; WP_005984760.1; NZ_JH470338.1.
DR AlphaFoldDB; G9PCX3; -.
DR STRING; 435830.HMPREF0045_00252; -.
DR PATRIC; fig|435830.3.peg.243; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_6_5_11; -.
DR OrthoDB; 9789078at2; -.
DR Proteomes; UP000003822; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000003822};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 56..257
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 304..612
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 321..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 642 AA; 68377 MW; CC3120982C7D5451 CRC64;
MPSLGKEFDR RQVLKFIGGG CATLIAARLV QLQVLEAKAL SEEGASAYTK VIEKLAQRGQ
IKDRKGQILA GSTITYDVGV NQIKLGSYVH TSPFKNADGS TTYKVVGYGP AEVAKQLAPI
LQMDRHELGG QLIGDSTYKI LAKDITPDEW RSIKVLGIPG VEPDSHVRRT YPSGAVAGNI
LGYVIEQAFY TFQDESGKMV EVNQDDLTEA QASAINSGTL YATRELRNVG QAGLELSRNK
ILTGTRGLER VEISINSDVL PNGVIEDKPA RRGQNITTTI DRDLQMLAQK ALDEHVKKMG
ARWGSVVVMD PASGDVLVLA DSNSVDPSQP SKTPEANRRS RTVEAVFDPG SVGKVVTFAA
ALDQGKITPE RSWVVPDAWT SSNGQSFSDS HEHETKSYTA TQILAESSNI GTIFVGDTIS
DEVRYNYMRK FGWGSLTGIE MPSESAGLLT SYSKWDGRQR YTTMFGQGVS TTALQAVSTL
ATVANKGVRV PPRLIKQYTD YTGKVTKPQA PTPTRVISEA SAATLEKMLV AVTQKGGTAE
SAAINGYQVA GKTGTSEIIG GEASGGTVAS FVGFLPAGLS KGKPAVAVSV VIYDPQAAIY
GGDVAAPVFS QVATAAMHNL GLAPDPQLVE KNPTSNPSQT PS
//
