ID   G9WX08_9FIRM            Unreviewed;       482 AA.
AC   G9WX08;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   RecName: Full=Radical SAM core domain-containing protein {ECO:0000259|PROSITE:PS51918};
GN   ORFNames=HMPREF9624_01382 {ECO:0000313|EMBL:EHL09341.1};
OS   Oribacterium asaccharolyticum ACB7.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Oribacterium.
OX   NCBI_TaxID=796944 {ECO:0000313|EMBL:EHL09341.1, ECO:0000313|Proteomes:UP000003527};
RN   [1] {ECO:0000313|EMBL:EHL09341.1, ECO:0000313|Proteomes:UP000003527}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ACB7 {ECO:0000313|EMBL:EHL09341.1,
RC   ECO:0000313|Proteomes:UP000003527};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Sizova M., Hazen A.,
RA   Epstein S., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Brown A.,
RA   Chapman S.B., Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C., Larson L., Lui A.,
RA   MacDonald P.J.P., Montmayeur A., Murphy C., Neiman D., Pearson M.,
RA   Priest M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA   Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Oribacterium sp. ACB7.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EHL09341.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AFZD01000021; EHL09341.1; -; Genomic_DNA.
DR   RefSeq; WP_009537158.1; NZ_JH414505.1.
DR   AlphaFoldDB; G9WX08; -.
DR   PATRIC; fig|796944.3.peg.2130; -.
DR   HOGENOM; CLU_046249_0_0_9; -.
DR   Proteomes; UP000003527; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0044271; P:cellular nitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0042364; P:water-soluble vitamin biosynthetic process; IEA:UniProt.
DR   CDD; cd01335; Radical_SAM; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR010722; BATS_dom.
DR   InterPro; IPR024007; FeFe-hyd_mat_HydG.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR034428; ThiH/NoCL/HydG-like.
DR   NCBIfam; TIGR03955; rSAM_HydG; 1.
DR   PANTHER; PTHR43583; 2-IMINOACETATE SYNTHASE; 1.
DR   PANTHER; PTHR43583:SF2; BIOTIN AND THIAMIN SYNTHESIS ASSOCIATED DOMAIN CONTAINING PROTEIN; 1.
DR   Pfam; PF06968; BATS; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   SFLD; SFLDG01060; BATS_domain_containing; 1.
DR   SFLD; SFLDF00319; Fe_hydrogenase_maturase_(HydG; 1.
DR   SMART; SM00876; BATS; 1.
DR   SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT   DOMAIN          92..305
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000259|PROSITE:PS51918"
FT   REGION          351..372
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   482 AA;  54746 MW;  5628CA1EB4495800 CRC64;
     MNYNPKSLQA EEFISHEEIL ETLRFADEKK NDRAYIESIL EKAKPIYNPN GSLHCGGLNH
     REASVLLACE IPDLNEKMIK LAEEIKLAFY GNRIVLFAPL YLSNYCVNGC TYCPYHAKNK
     TIARRKLTQE EIRQEVIALQ DMGHKRLALE AGEDPVHNPI EYILESIKTI YSIHHKNGDI
     RRVNVNIAAT TVENYRKLKE AGIGTYILFQ ETYHKKAYEE LHPTGPKHDY RYHTEAMDRA
     MEGGIDDVGI GVLFGLDKYR YEFAGLLMHA EHLEAVHGVG PHTISVPRLK KADDIDPTQF
     DNGIDDEIFS KIIACIRIAV PYTGMIISTR ESEEVRKKAL SMGISQISGA SRTSVGGYTD
     QERPHDTEQF DVSDQRTLDE VVKWLMDLGY IPSFCTACYR EGRTGDRFMA LCKSGQIQNC
     CHPNALMTLA EYLTDYASPE TGKCGEELIE KELATIPNAN RSRIAGEHIK SIYKSNKRDF
     YF
//