ID GALT_STAS1 Reviewed; 496 AA.
AC Q49ZK0;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=Galactose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE Short=Gal-1-P uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE EC=2.7.7.12 {ECO:0000255|HAMAP-Rule:MF_00571};
DE AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
GN Name=galT {ECO:0000255|HAMAP-Rule:MF_00571}; OrderedLocusNames=SSP0631;
OS Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS 20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=342451;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT pathogenesis of uncomplicated urinary tract infection.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC ChEBI:CHEBI:66914; EC=2.7.7.12; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00571};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000255|HAMAP-Rule:MF_00571}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00571}.
CC -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC type 2 family. {ECO:0000255|HAMAP-Rule:MF_00571}.
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DR EMBL; AP008934; BAE17776.1; -; Genomic_DNA.
DR RefSeq; WP_011302571.1; NZ_MTGA01000036.1.
DR AlphaFoldDB; Q49ZK0; -.
DR KEGG; ssp:SSP0631; -.
DR PATRIC; fig|342451.11.peg.634; -.
DR eggNOG; COG4468; Bacteria.
DR HOGENOM; CLU_047799_0_0_9; -.
DR OrthoDB; 2293at2; -.
DR UniPathway; UPA00214; -.
DR Proteomes; UP000006371; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00571; GalP_UDP_trans; 1.
DR InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR InterPro; IPR005850; GalP_Utransf_C.
DR InterPro; IPR005849; GalP_Utransf_N.
DR NCBIfam; TIGR01239; galT_2; 1.
DR PANTHER; PTHR39191:SF1; DUF4922 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR39191; GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR Pfam; PF02744; GalP_UDP_tr_C; 1.
DR Pfam; PF01087; GalP_UDP_transf; 1.
DR PIRSF; PIRSF006005; GalT_BS; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW Nucleotidyltransferase; Reference proteome; Transferase.
FT CHAIN 1..496
FT /note="Galactose-1-phosphate uridylyltransferase"
FT /id="PRO_1000025027"
SQ SEQUENCE 496 AA; 57233 MW; AF39FBA1ABDB80D3 CRC64;
MLLNQQLVQQ FVTQAIAFGD YEQEDNIYIQ NQLLRILNAI GIDVDNESPL NQDATANAIA
QYWIEQAVNE NYLEDALYKK EIVEAQILDL ITPRPSVINR NFVEAYKKSP ETATNYFYEI
TKRNHYVKED AIANNINYEV ETEYGDIEIT INLSKPEKDA KQIAKAKAEP AKHYPKCALC
IENEGYQGSV TQAARTNHRI IRLKLDGKSW GFQYSPYAYF PEHSIVLSEH HVPMEINKQT
FVNLLAFIEQ FPHYFIGSNA DIPLVGGSIL SHNHYQAGKH VFPMDNAAEI ERFTMNQFSS
VTASTLNWPM SVIRLKSENR DELINAATYV MNTWNQYSDE TIDVRAFSKD GERHHTVTPI
ARYRQSQYEL DIVLRDNQTS EVFPDGIFHP HEDVQHIKKE NIGLIEVMGT AILPGRLKEE
LQQVKTYLVG DNQFDLGIHQ QWAENMKRTY DINKQNVDDI VDKEVGYKFK RVLEDAGVFK
NTDTGRQAFK RFIKHL
//
