ID   GALU2_PSEAI             Reviewed;         279 AA.
AC   Q59633;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   13-SEP-2023, entry version 67.
DE   RecName: Full=UTP--glucose-1-phosphate uridylyltransferase;
DE            EC=2.7.7.9;
DE   AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase;
DE   AltName: Full=UDP-glucose pyrophosphorylase;
DE            Short=UDPGP;
DE   AltName: Full=Uridine diphosphoglucose pyrophosphorylase;
GN   Name=galU;
OS   Pseudomonas aeruginosa.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 10145 / DSM 50071 / JCM 5962 / LMG 1242 / NBRC 12689 / NCIMB
RC   8295 / NCTC 10332 / NRRL B-771;
RA   Chang H., Lee C., Peng H.;
RT   "Identification and characterization of UDPglucose pyrophosphorylase
RT   encoding gene in Pseudomonas aeruginosa ATCC10145.";
RL   Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in stationary phase survival. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC         alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC         ChEBI:CHEBI:58885; EC=2.7.7.9;
CC   -!- SIMILARITY: Belongs to the UDPGP type 2 family. {ECO:0000305}.
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DR   EMBL; U03751; AAB01486.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q59633; -.
DR   SMR; Q59633; -.
DR   GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR   CDD; cd02541; UGPase_prokaryotic; 1.
DR   InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   NCBIfam; TIGR01099; galU; 1.
DR   PANTHER; PTHR43197; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR   PANTHER; PTHR43197:SF1; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..279
FT                   /note="UTP--glucose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000201362"
SQ   SEQUENCE   279 AA;  30940 MW;  DF8D1A5A14165FA9 CRC64;
     MIKKYLFPAA GYGTRFLPAT KAMPKEMLPV VNKPLIQYGV EEALDAGLNE ISIVTGRGKR
     ALEDHFDISY ELENQIKGTD KEKYLVGIRK LLDECSFSYT RQTQMKGLGH AILTGRPLIG
     DEPFAVVLAD DLCVNLEGDG VLTQMVKLYQ KYRCTIVAVM EVNPTETNKY GVIAGDDIGD
     GLIRVRDMVE KPAPEDAPSN LAIIGRYILT PDIFKLIEET EPGKGGEIQI TDALLKQAKD
     GCVIAYKFKG QRFDCGGAEG YIEATNFCYE HFYKTGKAY
//