ID GLPK_CAEEL Reviewed; 502 AA.
AC Q21944;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 146.
DE RecName: Full=Probable glycerol kinase;
DE Short=GK;
DE Short=Glycerokinase;
DE EC=2.7.1.30;
DE AltName: Full=ATP:glycerol 3-phosphotransferase;
GN ORFNames=R11F4.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate;
CC Xref=Rhea:RHEA:21644, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:57597, ChEBI:CHEBI:456216;
CC EC=2.7.1.30;
CC -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase
CC pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC -!- SIMILARITY: Belongs to the FGGY kinase family. {ECO:0000305}.
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DR EMBL; FO081682; CCD73301.1; -; Genomic_DNA.
DR PIR; T16716; T16716.
DR RefSeq; NP_494721.1; NM_062320.4.
DR AlphaFoldDB; Q21944; -.
DR SMR; Q21944; -.
DR BioGRID; 39103; 1.
DR DIP; DIP-26828N; -.
DR STRING; 6239.R11F4.1.2; -.
DR EPD; Q21944; -.
DR PaxDb; 6239-R11F4-1-2; -.
DR PeptideAtlas; Q21944; -.
DR EnsemblMetazoa; R11F4.1.1; R11F4.1.1; WBGene00020007.
DR GeneID; 173747; -.
DR KEGG; cel:CELE_R11F4.1; -.
DR UCSC; R11F4.1.1; c. elegans.
DR AGR; WB:WBGene00020007; -.
DR WormBase; R11F4.1; CE04828; WBGene00020007; -.
DR eggNOG; KOG2517; Eukaryota.
DR GeneTree; ENSGT01000000214434; -.
DR HOGENOM; CLU_009281_2_2_1; -.
DR InParanoid; Q21944; -.
DR OMA; FMLMNIG; -.
DR OrthoDB; 2734344at2759; -.
DR PhylomeDB; Q21944; -.
DR Reactome; R-CEL-75109; Triglyceride biosynthesis.
DR UniPathway; UPA00618; UER00672.
DR PRO; PR:Q21944; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00020007; Expressed in larva and 3 other cell types or tissues.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004370; F:glycerol kinase activity; IBA:GO_Central.
DR GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006071; P:glycerol metabolic process; IBA:GO_Central.
DR GO; GO:0046167; P:glycerol-3-phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IBA:GO_Central.
DR GO; GO:0006641; P:triglyceride metabolic process; IBA:GO_Central.
DR CDD; cd07769; FGGY_GK; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000577; Carb_kinase_FGGY.
DR InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR InterPro; IPR018485; FGGY_C.
DR InterPro; IPR018484; FGGY_N.
DR InterPro; IPR005999; Glycerol_kin.
DR NCBIfam; TIGR01311; glycerol_kin; 1.
DR PANTHER; PTHR10196:SF69; GLYCEROL KINASE; 1.
DR PANTHER; PTHR10196; SUGAR KINASE; 1.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR PIRSF; PIRSF000538; GlpK; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS00933; FGGY_KINASES_1; 1.
PE 3: Inferred from homology;
KW ATP-binding; Glycerol metabolism; Kinase; Nucleotide-binding;
KW Reference proteome; Transferase.
FT CHAIN 1..502
FT /note="Probable glycerol kinase"
FT /id="PRO_0000059540"
FT BINDING 11
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 15
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 85
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 140
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 246
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 268
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 313
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 416..420
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 502 AA; 55165 MW; F0438E95F1A1B189 CRC64;
MVLLAAIDQG TSSSRFLVFE ADTGELVTSH QIEVRQLFPH GGWVEMDPME LYDTVVSCIS
KTIEKLENLG ISADEIKSVG VANQRETSIV WDKETGKPLY NAIVWLDTRT SSLADEAISR
TASKSKDEFR AKTGLPIHPY FSALKLKWLF QNVPEVKKAY ADGNLMFGTV DTWLIWKLTG
AYVTDVSNAS RTLLLDLHKR KWSTQLCEFF DLPIEILPEI RSSAEVYGHF DKGPLEGVPL
SGCLGDQQAA MVGHQCLNAG QTKNTYGTGT FMLCNIGTRP IISKNGLLTT VGFQFGADSP
VVYALEGSGS IGGNVVRFLR DNFKFISDAK EMEGLCRSVE DTSGAYFVPS FTGLYTPYWD
STARGTILGL TQVTQREHIC LAALRAVAFQ SAEMIAAVEQ DLEGGTKVTT LKVDGGMIAN
KLFNEIQADI MGRDIVTPKI TEISGWGAAV AGGIGAQQIS LDEFLQQSSE DNRYTPQKDD
NWRSAELARW KEAVKRSCGW AQ
//
