ID   H0BRW6_9BURK            Unreviewed;      1013 AA.
AC   H0BRW6;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=KYG_00500 {ECO:0000313|EMBL:EHL24982.1};
OS   Acidovorax sp. NO-1.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Acidovorax.
OX   NCBI_TaxID=512030 {ECO:0000313|EMBL:EHL24982.1, ECO:0000313|Proteomes:UP000003485};
RN   [1] {ECO:0000313|EMBL:EHL24982.1, ECO:0000313|Proteomes:UP000003485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NO-1 {ECO:0000313|EMBL:EHL24982.1,
RC   ECO:0000313|Proteomes:UP000003485};
RX   PubMed=22374962; DOI=10.1128/JB.06814-11;
RA   Huang Y., Li H., Rensing C., Zhao K., Johnstone L., Wang G.;
RT   "Genome Sequence of the Facultative Anaerobic Arsenite-Oxidizing and
RT   Nitrate-Reducing Bacterium Acidovorax sp. Strain NO1.";
RL   J. Bacteriol. 194:1635-1636(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR   EMBL; AGTS01000002; EHL24982.1; -; Genomic_DNA.
DR   AlphaFoldDB; H0BRW6; -.
DR   STRING; 512030.KYG_00500; -.
DR   REBASE; 45252; AspNO1ORF500P.
DR   PATRIC; fig|512030.4.peg.102; -.
DR   Proteomes; UP000003485; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0043412; P:macromolecule modification; IEA:UniProt.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR046819; MmeI_hel.
DR   InterPro; IPR046816; MmeI_Mtase.
DR   InterPro; IPR046820; MmeI_TRD.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR33841:SF6; DNA METHYLTRANSFERASE A; 1.
DR   PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   Pfam; PF20465; MmeI_hel; 1.
DR   Pfam; PF20473; MmeI_Mtase; 1.
DR   Pfam; PF20466; MmeI_TRD; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:EHL24982.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003485};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EHL24982.1}.
FT   DOMAIN          198..267
FT                   /note="MmeI-like helicase spacer"
FT                   /evidence="ECO:0000259|Pfam:PF20465"
FT   DOMAIN          372..604
FT                   /note="MmeI-like DNA-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF20473"
FT   DOMAIN          679..834
FT                   /note="MmeI-like target recognition"
FT                   /evidence="ECO:0000259|Pfam:PF20466"
SQ   SEQUENCE   1013 AA;  111041 MW;  962611658ADAF077 CRC64;
     MTPQDFIAKW GAPGGVPGPA YALNEEQGAQ SHFLDLCELL GVPKPGSAEG YRFEEKSAVI
     GGKTGYCDVF MRGVFAWENK APGKNLDTAL KQLLTYSLAL SNPPILVVSD RLSIRIHTQF
     TGHPSATHTV AIDEMDQPDK LALLRRIWQA PESFKPRQTN RDITEAAARS FAALAEGLRQ
     RGATNDEAAA SQQQRANQVA HFLTQCLFCF FAEDVGLLPG RMFERLLNNK QATPERLGQG
     LTQLFSAMKD GGLYGVDDIP WFNGGLFQTI AVPALSAPDL AELRRAADLD WSAIDVSIFG
     TLFERGLDPA KRSQLGAHYT DPATIERLIN PVIRRPLLQK WELVAQQIQG LAAKITKKGD
     KHYRAAHALF VTWLDELKHF RALDPACGSG NFLYLALKCL KDVEHHSHLQ ATELGLDREA
     DLVTGPHNVL GIELNEYAAE LARVTVWIGE LQWRLAHGYE FKTNPVLDTL EHIECRDALL
     AEGGAEAAWP AADVVVGNPP FLGDKKMRAE LGDATTTLLR KTYEGRVPGG ADLVCYWFDK
     ARAQMAAGQL LRAGLVTTNS IRGGANRKVL DAICTQTRIF EAWSDEPWVN NGAAVRVSLV
     AFGTAEQPAL LDGSPVSAIY SDLHAAGEHT TDLSTAQRLR TNAGVSFQGP VLVGDFEVGA
     DIAIAWLASP NPHGHSNAEV LRPLTNGKDI TSRSRGLWVV DFSSRPIAEA SLYTEPFTHV
     EKAVKPMRMA SNDASRKARW WLHGRSGTDY RAATAQIPRY LATSQVSKHR VFVWQPSIVW
     PHQTVIAIAR ADDTTFGILH SRFHELWALR MGTSLEDRPR YTPTTCFETF PFPAGLTPAD
     TAHQRTEAVE GGALIPADLP DTLSDALPTE DFKPNQPLAP AHQAPAAIKT IPPRQAATAI
     AQAAQRLNAL RQAWLNPPEW TDTVPEVVPL GLQHSPYPDR TVPKPGFEKD LAKRTLTNLY
     NQRPAWLAAA HAQLDAAVAA AYGWADYTAD MPDDEILRRL LALNLQRCTS EGA
//