ID H0EBL9_9ACTN Unreviewed; 648 AA.
AC H0EBL9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Penicillin-binding protein transpeptidase domain-containing protein {ECO:0000259|Pfam:PF00905};
GN ORFNames=PAI11_42510 {ECO:0000313|EMBL:EHN08927.1};
OS Patulibacter medicamentivorans.
OC Bacteria; Actinomycetota; Thermoleophilia; Solirubrobacterales;
OC Patulibacteraceae; Patulibacter.
OX NCBI_TaxID=1097667 {ECO:0000313|EMBL:EHN08927.1, ECO:0000313|Proteomes:UP000005143};
RN [1] {ECO:0000313|EMBL:EHN08927.1, ECO:0000313|Proteomes:UP000005143}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=I11 {ECO:0000313|EMBL:EHN08927.1,
RC ECO:0000313|Proteomes:UP000005143};
RX PubMed=23212173; DOI=10.1007/s10532-012-9610-5;
RA Almeida B., Kjeldal H., Lolas I., Knudsen A.D., Carvalho G., Nielsen K.L.,
RA Barreto Crespo M.T., Stensballe A., Nielsen J.L.;
RT "Quantitative proteomic analysis of ibuprofen-degrading Patulibacter sp.
RT strain I11.";
RL Biodegradation 24:615-630(2013).
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHN08927.1}.
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DR EMBL; AGUD01000311; EHN08927.1; -; Genomic_DNA.
DR RefSeq; WP_007579079.1; NZ_AGUD01000311.1.
DR AlphaFoldDB; H0EBL9; -.
DR PATRIC; fig|1097667.3.peg.4213; -.
DR Proteomes; UP000005143; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF24; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE PBPA; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF54427; NTF2-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005143};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 77..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 345..566
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 648 AA; 66335 MW; 5323059907A079F9 CRC64;
MPASGRRRPP QRSSGGTARA PAPRAAGGAR GGGSGISGGA GGRRTPPGSP IRAAGDRGGR
PPVGRARRGS GPGGRRPLLL IALLALLIAA GVGAYLVLDA RASRQAERDT VDAYLRAWTA
QDPGAMYGHV SDDVRSRTSE QRFAQLVRDP LGVATVQQLR IGKPKRDGDA FDVPVLARTR
LFGTISATVR LPLVGSGDQA RIRWAKRLTF PGLRDGETLT RTTDMPARAT ILARDGKTAI
AEGESRSSPV PNLAQQVRGD LGTAKPEDAA MLKRLGVPAD AKVGVSGLER ILNPQLIGKP
GGTLKAGDRV LKRVAPEKAT AVRSSISLAV VKAAAEAQQD APAGGGVVVL NSRTGEVLGF
QGLAWSVLQP PGSTMKIITA AAGLEDGVAK TTTSYPVATE ALGIQNSNQE SCGGTLVQSF
AHSCNSVFAP MAVKLGSKRF VEMAERFGFN TPPGVPGAQT SQLPKEIGVG DLAQSGIGQA
QVQATALQVA LMSATIANGG RMPKLTFLRS TKAAPAKRII KPSTARDMRQ LMLAVISGGT
GQKAAVPGVT TAGKTGTAEL RATQGDHCES QAAPDAEPGA EAPPVDSACG NKDGTNTDAW
MAAFAPATRS GGNDPLAIGV LRISNFQGGE TAAPVASKVL KAALDATG
//
