ID H0JY96_9NOCA Unreviewed; 1944 AA.
AC H0JY96;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:EHK80632.1};
GN ORFNames=AK37_23704 {ECO:0000313|EMBL:EHK80632.1};
OS Rhodococcus pyridinivorans AK37.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus.
OX NCBI_TaxID=1114960 {ECO:0000313|EMBL:EHK80632.1, ECO:0000313|Proteomes:UP000005064};
RN [1] {ECO:0000313|EMBL:EHK80632.1, ECO:0000313|Proteomes:UP000005064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AK37 {ECO:0000313|EMBL:EHK80632.1,
RC ECO:0000313|Proteomes:UP000005064};
RA Kriszt B., Tancsics A., Cserhati M., Toth A., Nagy I., Horvath B.,
RA Tamura T., Kukolya J., Szoboszlay S.;
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHK80632.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AHBW01000064; EHK80632.1; -; Genomic_DNA.
DR RefSeq; WP_006554621.1; NZ_AHBW01000064.1.
DR PATRIC; fig|1114960.4.peg.4831; -.
DR UniPathway; UPA00011; -.
DR Proteomes; UP000005064; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd19540; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 538..613
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1598..1674
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1944 AA; 207945 MW; 6041D3EC5CCFE474 CRC64;
MTTSAIGPES SPAVSADAHR QRGSRRWNHR LRRRPATALL PHLLAAAVER DPSGIAMVSE
SGSTTYAELD AASSRLARLL IGRGIGPEDV VALAFVRSPE SVVATWAVAK TGAAFVPVDP
TYPPDRVEHM VVDSGAVTGL TLSDTTSSLP ETVEWLRIDA PDVSSEAEAL PSTPVGFDER
RGPLRPDNAA YVIYTSGSTG RPKGVVVTHT GLANFCAEQV ERYGLTADSR TLHFASPSFD
ASVLELLLAV GASSTMVVTP RSVFGGGEFA EFVLQHGVTH AFVTPAALSS VDPSGLGVLN
TVVVGGEACP PELVTRWAPG RRFFNGYGPT ETTIMSNISD ELAPGDRVTI GPPIRNVSES
VLDSRLHPVP VGVVGELYVS GPGVARGYHG RPGLTATRFV AAAGGTRMYR TGDVVRGPES
ADAGIVYVGR NDFQVKVRGF RIELGEIDAA LSSFPGVDFA VTLGRPTPAG ETRLVAYVHG
AGAALDADVL TRHVADLLPA YMVPAAVVVL DRIPLTPSGK VDRAALPEPG ITATEFRSPA
TVSERAIAEV FADVLGVDRV GLDDNFFDLG GNSLLATSVT GRLRTRLGVT VGAAALFEEP
TVAGLACRLD ATSSGGTVPL VARLRPARLP LSYAQQRMWF LNRLDPESAV YNIPLAVRLA
GTLDIDAMRT AFADIVERHE TLRTVYPEVD GTGEQRILEP GRVTVDVPVE QVPAEALVER
LATVAGRGFD VTAEVPVRAH LFETGTDDHV LMLVMHHIAG DGTSLAPLVR DLVTAYTARA
EGRPPAWTPL PVQYADYTLW QREVLGSDDD PGSVAGRQLA YWTEALAGIP DHLDLATDHV
RPAILGSGGG TVRTELDGDT YESITALARR TGTTPFMVVH AALAALLARL SNTHDVVIGT
PVAGRSAPEL DDLVGMFVNM LALRTDVDLG ASFTELLDQA RRVDIAAFDH ADVPFERLVE
VLDPVRSPAR HPLFQVGLSY HNFTLDALEL PGLRVEPLDA SSSSVRFDLH VTIVDRGVNG
GPGGFDIEFG YATDLFDESS VRRMVDRYLR ILSVVADDAD VVVGDIDLHD PDQLAAMLEA
WEAEQVAVGP GRTLADLFAD QVRSTPSACA LVDAKSELTY GEFATRVRRL ARMLIEHGVG
PETVVALPIR RSIDLVVAMY AVVEAGGAYL PLDPDHPRER IEYIVESADP ACVLTTGRDR
IDLPGDRPTI EVDTVDLAAY DGRALRNSDR LAPLRAGNAA YVIYTSGSTG RPKGVVVSHE
AIVNQLVWKK NEYRLGAGDA VLLKTAATFD LSVWEFWSAP TSGAKLVIAS PDGHRDPAYL
NDLIRRENVT TLHVVPSMLD ALLDDAEGEL PGSLRRVLAI GEVLPVDTAE RTLEHSDTDL
VNLYGPTEAA VSVTAHRVTE TAETSVPIGS PIPNTQVFVL DDRLHPVPPG VAGELYLAGA
QLARGYLGRP ELTSERFVAN PFGAPGTRLY RTGDVVRWRF DDDGLSGTLE YLDRADFQVK
VRGFRIELGE IESALRALPQ VRDAVVTVQN GDRIVAFVVP VAESPDIASI RAALTRTLPS
YMVPQGFVTL DVLPLNANGK LDRKALPEAE VASAPYRAPR SRTETVVASI YAEVLGTRDR
VGLDDDFFGI GGNSLSAVKV AARLRDVLDA HVELPWLFLH SGVEELAARI DAHGDSARDA
LGDAGLDLVL PLRAGGEGAP VFCIHPVTGL AWGFAGLVPY LGDRPVYGLQ SPALGASGAL
PSSIDAWADE YARRIREIHP HGPYHLVGWS MGGILAQAVA IRLRRAGQEV PTLALLDAYP
ETRGAAAPER ATAPTVAEVL GFGRDVPEAS VPFTELTPEN AQKIVEGLPA PFDVLTPERI
ERIVEGVRHS YTLLASHRPE VYDGDLTVFV AEADRSASSA ETWYPFVNGL VTTREVPVSH
WDLATRKAWA VIGPALGRRL DSGR
//
