ID   H0TP12_9BRAD            Unreviewed;       341 AA.
AC   H0TP12;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=Acetylpolyamine aminohydrolase (Histone deacetylase family) {ECO:0000313|EMBL:CCE08200.1};
GN   Name=aphA {ECO:0000313|EMBL:CCE08200.1};
GN   ORFNames=BRAS3843_2650023 {ECO:0000313|EMBL:CCE08200.1};
OS   Bradyrhizobium sp. STM 3843.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Nitrobacteraceae; Bradyrhizobium.
OX   NCBI_TaxID=551947 {ECO:0000313|EMBL:CCE08200.1, ECO:0000313|Proteomes:UP000002686};
RN   [1] {ECO:0000313|Proteomes:UP000002686}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=STM3843 {ECO:0000313|Proteomes:UP000002686};
RX   PubMed=24704842; DOI=10.3390/genes3010035;
RA   Mornico D., Miche L., Bena G., Nouwen N., Vermeglio A., Vallenet D.,
RA   Smith A.A., Giraud E., Medigue C., Moulin L.;
RT   "Comparative genomics of aeschynomene symbionts: insights into the
RT   ecological lifestyle of nod-independent photosynthetic bradyrhizobia.";
RL   Genes (Basel) 3:35-61(2011).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the histone deacetylase family.
CC       {ECO:0000256|ARBA:ARBA00005947}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCE08200.1}.
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DR   EMBL; CAFK01000185; CCE08200.1; -; Genomic_DNA.
DR   RefSeq; WP_008970712.1; NZ_CAFK01000185.1.
DR   AlphaFoldDB; H0TP12; -.
DR   OrthoDB; 9808367at2; -.
DR   Proteomes; UP000002686; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd10001; HDAC_classII_APAH; 1.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625:SF9; HISTONE DEACETYLASE 8; 1.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:CCE08200.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002686}.
FT   DOMAIN          28..335
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
SQ   SEQUENCE   341 AA;  36307 MW;  58D2D9763EB7CF6C CRC64;
     MKAVYSELHR SHDPQFYLVR GVVKRTTEQP ERADRLLAGL KAGNHRVVAP INFGQGPRAR
     VHSPEYLSFL AEAWEAWAAL GDSGSEMIPN IHPVRNAGTY PTHIVGRLGW HTTDTSAPIG
     PGTWAGACAA TDIATTAAQL VMDGEDATYA LCRPPGHHAY RDIASGFCFM NNSAIAAAHL
     RLTHERVAIL DVDVHHGNGT QGIFYERGDV LTVSIHADPV SYYPFVWGYA HERGAGAGLG
     ANLNIPLPMK TGDDGYMNAL ETAAKTIRAF APGALVVALG LDASEHDPLA GLAVTTAGFK
     RIGAAIARLG LPTVFVQEGG YLSDILGQNL TAVLAGFEEA R
//