ID H0UVL9_CAVPO Unreviewed; 728 AA.
AC H0UVL9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Golgin subfamily A member 5 {ECO:0000256|ARBA:ARBA00020370};
DE AltName: Full=Golgin-84 {ECO:0000256|ARBA:ARBA00032404};
GN Name=GOLGA5 {ECO:0000313|Ensembl:ENSCPOP00000001062.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000001062.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000001062.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000001062.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in maintaining Golgi structure. Stimulates the
CC formation of Golgi stacks and ribbons. Involved in intra-Golgi
CC retrograde transport. {ECO:0000256|ARBA:ARBA00024833}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004409}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004409}.
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DR EMBL; AAKN02053401; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02053402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003462684.1; XM_003462636.3.
DR RefSeq; XP_005000332.1; XM_005000275.2.
DR AlphaFoldDB; H0UVL9; -.
DR STRING; 10141.ENSCPOP00000001062; -.
DR Ensembl; ENSCPOT00000001190.3; ENSCPOP00000001062.2; ENSCPOG00000001178.4.
DR GeneID; 100713522; -.
DR KEGG; cpoc:100713522; -.
DR CTD; 9950; -.
DR VEuPathDB; HostDB:ENSCPOG00000001178; -.
DR eggNOG; KOG4677; Eukaryota.
DR GeneTree; ENSGT00390000018470; -.
DR HOGENOM; CLU_022484_0_0_1; -.
DR InParanoid; H0UVL9; -.
DR OMA; CSSYEAH; -.
DR OrthoDB; 3152258at2759; -.
DR TreeFam; TF319468; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000001178; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0005801; C:cis-Golgi network; IEA:Ensembl.
DR GO; GO:0031985; C:Golgi cisterna; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0007030; P:Golgi organization; IEA:Ensembl.
DR GO; GO:0048193; P:Golgi vesicle transport; IEA:Ensembl.
DR Gene3D; 1.20.5.1700; -; 1.
DR InterPro; IPR019177; Golgin_subfamily_A_member_5.
DR PANTHER; PTHR13815:SF7; GOLGIN SUBFAMILY A MEMBER 5; 1.
DR PANTHER; PTHR13815; GOLGIN-84; 1.
DR Pfam; PF09787; Golgin_A5; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 696..716
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 83..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 221..269
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 305..410
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 458..577
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 147..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 728 AA; 82618 MW; 76E0E4D3F04230F7 CRC64;
MSWLVDLAGK AEDLLNRVDQ GAATALSRKE TTTSRIADYP ELHQQNTDLT YQTGPKATYI
SSAADNIRNQ KATILAGTAN VKVGSRTPGE ASHPVENASV PRPSSQFVRR KKSEPDDELL
FDFLNSSQKE PTGRVELKKE KGKAPVFPSS RTSNVSSVNT DVTTVKANEE NSGSQSHDVA
SNSDHESEGQ EDSSKKDASS NAAIHTDHNP ASGENGNSHE LSNLRLENQL LRNEVQSLNQ
EMASILQRSK ESQEELNKAR ARVEKWNADH SKSDRVTREL RAQVDDLTEA VAAKDSQLAV
LKVRLQEADQ LLSTRTEALE ALQSEKSRIM QDHNEGSSLQ NQALQTLQER LHEADATLKR
EQESYKQMQN EFATRLNKME MERQNLAEAV TLAERKYSDE KKRTDELQQQ VKLHKLNWES
SKQELIDYKQ KATRILQSKE KLINSLKEGS GFEGLDSSAT TSMELEELRH EKEMQREEIQ
KLMGQIHQLR SELQDMEAQQ VSEAESAREQ LQDLQDQIAR QKVSKQELET ELDRLKQEFH
YIEDDLYRTK NTLQSRIKDR EEEIQKLRNQ LTNKALSNSS QSELESRLHQ LTETLIQKQT
MLESLSTEKN SLVFQLERLE QQMNSASAGA INGPSINMSA VDSGEGTRLR NVPVLFNDSE
TNLAGMYGKV RKAASSIDQF SIRLGIFLRR YPIARVFVII YMALLHLWVM IVLLTYSPEM
HRDQPYSR
//
