ID H0UVX2_CAVPO Unreviewed; 598 AA.
AC H0UVX2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=PHD finger protein 21A {ECO:0000313|Ensembl:ENSCPOP00000001178.3};
GN Name=PHF21A {ECO:0000313|Ensembl:ENSCPOP00000001178.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000001178.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000001178.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000001178.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02046837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02046838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02046839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02046840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02046841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02046842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0UVX2; -.
DR Ensembl; ENSCPOT00000001315.3; ENSCPOP00000001178.3; ENSCPOG00000001299.4.
DR VEuPathDB; HostDB:ENSCPOG00000001299; -.
DR GeneTree; ENSGT00940000156124; -.
DR HOGENOM; CLU_020260_1_0_1; -.
DR TreeFam; TF331518; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000001299; Expressed in testis and 12 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15523; PHD_PHF21A; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR24102; PHD FINGER PROTEIN; 1.
DR PANTHER; PTHR24102:SF6; PHD FINGER PROTEIN 21A; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 405..452
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 82..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 30..57
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 479..517
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 82..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..145
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..598
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 598 AA; 66416 MW; CC8ADEF75FA84CEA CRC64;
MELQTLQEAL KVEIQVHQKL VAQMKQDPQN ADLKKQLHEL QAKITALSEK QKRVVEQLRK
NLIVKQEQPD KFQIQPLPQS ENKLQTAQQQ PLQQLQQQQQ YHHHHAQQPA AASPTLTASQ
QVQATPPQPI KVPQFIPPPR LTPRPNFLPQ VRPKPVAQNN IPIAPAPPPM LAAPQLIQRP
VMLTKFTPTT LPTSQNSIHP VRVVNGQTAT IAKTFPMAQL TSIVIATPGT RLAGPQTVQL
SKPSLEKQTV KSHTETDEKQ TESRTITPPA APKPKREENP QKLAFMVSLG LVTHDHLEEI
QSKRQERKRR TTANPVYSGA VFEPERKKSA VTYLNSTMHP GTRKRGRPPK YNAVLGFGAL
TPTSPPSSHP DSPESEKTET TFTFPQPVQP VSLPSPTSTD GDIHEDFCSV CRKSGQLLMC
DTCSRVYHLD CLDPPLKTIP KGMWICPRCQ DQMLKKEEAI PWPGTLAIVH SYIAYKAAKE
EEKQKLLKWS SDLKQEREQL EQKVKQLSNS ISKCMEMKNT ILARQKEMHS SLEKVKQLIR
LIHGIDLSKP VDSEAAVGAI SNGPDCTPPA SAPASTPTPS PSSSQSCTAN CTPGDETK
//
