ID H0UX76_CAVPO Unreviewed; 4854 AA.
AC H0UX76;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=[histone H3]-lysine(4) N-methyltransferase {ECO:0000256|ARBA:ARBA00023620};
DE EC=2.1.1.364 {ECO:0000256|ARBA:ARBA00023620};
GN Name=KMT2C {ECO:0000313|Ensembl:ENSCPOP00000001682.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000001682.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000001682.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000001682.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) +
CC N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364;
CC Evidence={ECO:0000256|ARBA:ARBA00024515};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60265;
CC Evidence={ECO:0000256|ARBA:ARBA00024515};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AAKN02032938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02032939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02032940; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02032941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02032942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSCPOT00000001878.3; ENSCPOP00000001682.3; ENSCPOG00000001857.4.
DR VEuPathDB; HostDB:ENSCPOG00000001857; -.
DR eggNOG; KOG4443; Eukaryota.
DR GeneTree; ENSGT00940000155281; -.
DR HOGENOM; CLU_000065_3_0_1; -.
DR TreeFam; TF354317; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000001857; Expressed in cerebellum and 12 other cell types or tissues.
DR GO; GO:0044666; C:MLL3/4 complex; IEA:InterPro.
DR GO; GO:0140999; F:histone H3K4 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15696; ePHD1_KMT2C; 1.
DR CDD; cd15697; ePHD2_KMT2C; 1.
DR CDD; cd22026; HMG-box_KMT2C; 1.
DR CDD; cd15509; PHD1_KMT2C_like; 1.
DR CDD; cd15594; PHD2_KMT2C; 1.
DR CDD; cd15511; PHD3_KMT2C; 1.
DR CDD; cd15513; PHD5_KMT2C_like; 1.
DR CDD; cd15600; PHD6_KMT2C; 1.
DR CDD; cd19171; SET_KMT2C_2D; 1.
DR Gene3D; 3.30.160.360; -; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 7.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003889; FYrich_C.
DR InterPro; IPR003888; FYrich_N.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR041967; KMT2C_ePHD1.
DR InterPro; IPR041968; KMT2C_ePHD2.
DR InterPro; IPR047004; KMT2C_PHD2.
DR InterPro; IPR047005; KMT2C_PHD6.
DR InterPro; IPR037877; PHD3_KMT2C.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE 2C; 1.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR Pfam; PF05965; FYRC; 1.
DR Pfam; PF05964; FYRN; 1.
DR Pfam; PF00628; PHD; 4.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00542; FYRC; 1.
DR SMART; SM00541; FYRN; 1.
DR SMART; SM00249; PHD; 8.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 6.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50216; DHHC; 1.
DR PROSITE; PS51805; EPHD; 2.
DR PROSITE; PS51543; FYRC; 1.
DR PROSITE; PS51542; FYRN; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50016; ZF_PHD_2; 6.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 159..263
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 273..323
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 276..321
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 320..370
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 396..452
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 884..937
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 934..984
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1011..1066
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 4342..4450
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 4714..4830
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 4838..4854
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 20..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 97..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 755..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1144..1251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1385..1409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1529..1555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1633..1693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1709..2351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2523..2572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2655..2674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2762..2811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2862..2895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3145..3171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3207..3360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3467..3515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3550..3707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3722..3859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3964..4009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4085..4109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1152..1199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1388..1409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1530..1555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1633..1654
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1655..1682
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1709..1777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1797..1829
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1868..1900
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1990..2004
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2046..2066
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2075..2096
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2097..2116
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2117..2139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2141..2160
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2239..2259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2266..2314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2324..2338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2553..2572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2763..2788
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2862..2878
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3207..3226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3232..3254
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3255..3273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3313..3329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3342..3360
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3467..3499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3572..3595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3596..3610
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3619..3642
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3685..3702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3724..3739
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3740..3756
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3783..3818
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3819..3837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3838..3852
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4854 AA; 535423 MW; 21CF30D2F6C2B2B5 CRC64;
MDGLETTETE NIVETVEIKE HSAEEDAEAE VDSSKQPVPT LQQPASEESV NFLVSVGVEA
KISEQLCAFC YCGEKSSLGQ GDLKQFRVTP GFILPWQSQP SNKDIDDSSS GTYERVQNST
PRRQRGQRKE RALQQNMVSC MSVSTQTVAD DQAGKLWDEL SLVGLPDAID VQALFDSAGT
CWAHHRCVEW SLGVCQVEEP LLVNVDKAVV SGSTERCAFC KHLGATIKCC EEKCTQMYHY
PCAAGVGTFQ DFSHFFLLCP EHIDQAPERS KEDANCAVCD SPGDLLDQFF CTTCGQHYHG
MCLDIAVTPL KRAGWQCPEC KVCQNCKQSG EDSKMLVCDT CDKGYHTFCL QPVMKSVPTN
GWKCKNCRIC VECGTRSSSQ WHHSCLVCDA CYQQQDNLCP FCGKCYHPEL QKDMLHCNIC
KRWVHLECDK PTDHELDSQL KEEYICMYCK HLGAEMDPLQ PGDEMEMAEP ATDSNNEMEV
GGTEEQMVFL EQGVNKDVSD QESVPGIDPD VQVIHTEEQQ KNKLPEGIDK DCLLLSETSP
NKVNSELENE LSCGVVCEKM DLPSKRTHLH DKDEKEDKME VAVNIDAPTY QIVVQQELQL
LPDPQGVICK EAAQPLAAGV ESVTVPPVAL VSPSEESTSC SKEQLITERL HEEIEQKENS
EFSTEFMDFE MTSAVESCVK DGLCLGDKSL KLPTEVESSF SPDIGKTNVS SSPTLRLDLP
SHNMLHSYSS TLNSSGNIMP TTYISVTPKI GMGKPAITKR KFSPGRPRSK QGAWSTHNTV
SPPPWSPDIS EGREIFKPRQ LPGSAIWSIK VGRGSGFPGK RRPRGAGLSG RGGRGRSKLK
NGIGAVVLPG VSAADISSNK DEEENSMHNT VVLFSSSDKF TLHQDMCVVC GSFGQGAEGR
LLACSQCGQC YHPYCVSIKI TKVVLSKGWR CLECTVCEAC GKATDPGRLL LCDDCDISYH
TYCLDPPLQT VPKGGWKCKW CVWCRHCGAT SAGLRCEWQN NYTQCAPCAS LSSCPVCYRN
YREDDLILQC RQCDRWMHAV CQNLNTEEEV ENVADIGFDC SMCRPYIPAS NVPSSECCES
SLVAQIITKV KELDPPKTYT QDGVCLTESG MTQLQSLTVT VPRRKRSKPK LKLKIINQNS
VAVLQTPPDI QSEHSRDGEM DDSREAELMD CDGKSESSPE REAVDEETKG VEGTDGVKKR
KRKPYRPGIG GFMVRQRSRT GQGKTKRCVI RKDSSGSISE QLPSRDDGWG EQLPDTLIDE
SVSVAENTEK IKKRYRKRKN KLEETFPAYL QEAFFGKDLL DTSRQNKLNL DNVSEDAAQL
MYKTNTNTGF LEPSFDPLLN SSTPAKPGTQ GTADDPLADI SEVLNTDDDI LGIISDDLAK
SVSHSDIGSI ADDPSSLPQP SVSQTSRPLT EEQLDGILSP ELDKMVTDGA ILGKLYKIPE
LGGKDVEDLF TAVLSPVNTQ PAPLPQPPPP PQLLPMHNPD VFSRMPLMNG LIGPSPHLPH
NSLPPGSGLG TFSAIQSHYT DARDKNAAFN PITNDPNSSW TPSAPSVEGE NDTMSNAQRS
TLKWEKEEAL GEMATVAPVL YTNINFPNLK VEFPDWTTRV KQIAKLWRKA SSQERAPYVQ
KARDNRAALR INKVQMSNDS MKRQQQQDST DSSSRIDSDL FKDPLKQRES EHEQEWKFRQ
QMRQKSKQQA KIEATQKLEQ VKNEQQQQQQ QQQQQQQQQQ QQQHGSQHLL MPSGSDTPSS
GVQSPLTPQP SNGNMSPAQT FHKDLFSKQQ PSAPASASSD AVFVKPQAPP PPSTTSRVPV
QDGLSQSQMS QPHSPQMFSP GSSNSRPPSP IDPYAKMVGT PRPPPGGHSF CRRNSVAPVE
NCVPLSSVPR PIQMSETPAN RPSPSRDLCS SSTTNNDPYA KPPDTPRPMV TDQFPKPLGL
PRSPMVSEQT AKGPPAAGTG DHFTKPSPRG DTFQRQRIPD PYARPLLASA PADSSSGPFK
TPLHPPPSSQ DPYGSMSQAS RRLSVDTYER PPLTPRPVDN FPHSQSNDPY SQPPHIPHPA
MNESFAHSSR AFSQPGTISR SAPQDPYSQP PGTPRPVVDS YSQPSGTTRS NLDPYSQPPG
TPRPTTVDPY SQQPPTPRPS IQTDMFVTSA ANQRHSDPYS HPPGTPRPGI STPYSQPPAT
PRPRTSEGFT RPSGARPALV PNRDPFLQAA QHRAPALPSS LVRPPDMCSQ TPRPPGSGLP
DTFSRVSPSA ARDPYDQPPM TPRSQSDSFG SSQVTRDITD QAGAGPEEGF NTSANSAVSS
QGPQFSSIAQ APGPVSTSGG TDTQNTVNMS QADTEKLRQR QKLREIILQQ QQQKKIASRQ
EKGPQDTPAV PHPVPLPNWQ PESISQAFSR PPPPYPGNIR SPMVPLPGPR YAVFPKDQRG
PYPPDVAGMG MRPHGFRFGF SGSSHGTMSG QDRFLVPPQQ IQGSGIPPHL RRSVSVEMPR
PLNNSQMNNP VGLPQHFPPQ SLPVQQHNIL GQAFIELRHR APDGRPQHPF PTTPGNVIEA
PSHPRHGNFI PRPDFPGLKH TEPMRRPHQG LPSQLSMHPN LEQVPSQQEQ GHPLHASSVV
MRHMSHSLGT GFSEAPLSTS VSAEAAPDNL QITSQASDSL EEKLDSDDPS VKDLDVKDLE
GVEVKDLDDE DLENLNLDTE DGKGDELDTL DNLETNDPNL DDLLRSGEFD IIAYTDPELD
LGDKKSMFNE ELDLNVPIDD KLDNQCVSVE PPQKEQEDKI VVLSENHLPQ KKSNIVSEIK
TEVLSPDSKE EAKCETEKNE KSDEIGDHVE PPCTQASAHT DLSDGEKACL PPCEPELLEK
RANRETDDSS ASIIQGSTPL AAQDIVNSCD ITGSTPVLSS LLASEKSDSS DNRSLGSPPP
TVPASPSNHV SSLPSALMAP PGPVLDNAMN SNVTVVSRVN HTFSQGVQVN PGFIQGQSTV
NHSLGKGKPT NQCAPVTSQS GSSAISGSQQ LMMPQTLGHQ NRERPLLLEE QPLLLQDLLD
QERQEQQQQR QMQAMIRQRS EPFFPNIDFD AITDPIMKAK MVALKGINKV MAQNNLGMPP
MVMSRFPFMG PATAGAQNSE GQTPMPQTVT QDGSITHQIS RPNPPNFGPG FVNDSQRKQY
EEWLQETQQL LQMQQKYLEE QIGAHRKSKK ALSAKQRTAK KAGREFPEED AEQLKHVTEQ
QSMVQKQLEQ IRKQQKEHAE LIEDYRIKQQ QQQQQQQQQQ QQQRAMAPPL LMPGIQPQPP
RLPGATPPAI NQPSFPMVPQ QLQHQQHTAA LSGHNSPARM PGLPGWQSAS APAHLPLNPP
RIQPPMAQLP VKACTPTTGT VSNANPQSGP PPRVEFDDNN PFSESFQERE RKERLREQQE
RQRIQLMHEV DRQRALQQRM EMEQHGLIGS EVGNRTPVSQ IPFYGSDRPC DFMQPPRPLQ
QSPQHQQQMA LVLQQQNVQQ GSVNSSPTQT FMQTNDRRQG ALTSFIPDSS SVPSGSPNFH
SAKQGHGNLS GTSFQQSPLR PPFAPALPTT SPVANSSLPC GQDLAVAHGQ SYGSSQSLIQ
LYSDIIPEEK GKKKRTRKKK KEDDVESTKA PLTPHSDITA PLTPSISETT STPTVNTPND
PPPQSEPEPA EPAGQPGTDL ENTLPSADLS LETPNQEACA NSEAKTLPME MPAKNEELKL
ENTETESGLG QEETESEEQT GCKAQDKSEA SPVSSVQSPL DSVGAPVTKA DLGNELLKHL
LKNKKSSSLL NQRSEGSFCS EDNCTKDSKT AEKQNPEERM QTLGVHVQGG FGCGNNQPKM
DGGSETKKQR NKRTQRTGEK AAPRSKKRKK DEEEKQPMYP NSDSFTHLKQ QNNLSNPPTP
PASLPPTPPP MACQKMANGF ATTEELAGKA GVLVSHEVTK TLGPKPFPLP FRPQDDLLAR
AVAQGPKTVD VPASLPTPPH NNHEEIRIQD HCGDRDTPDS FVPSSSPESV VGVEVSRYPD
LSVVKEEPPE PVPSPIIPIL PSTTGKSSES RRNDIKTEPG TLFFTSPFGS SSNGPRSGLI
SVAITLHPTA AENINSVVAA FSDLLHVRIP NSYEVSSAPD VPPMGSTMGL VSSPRVNPGL
EYRPHLHLRG PPPGSANPPR LATSYRLKQP NVPFPPASSG LPGYKDPSHG AAGKAALRPQ
WCCHCKVVIF GSGVRKSFKD LAFMNKDSRE SNKRMEKDIV FCSNNCFILY STAQSKNPES
KESLPPLPQS PMREMPSRAF HQYSNNISAL DVHCLPQLQE KASPPPSPPI AFPPALEAAQ
VEAKPDELKV TVKLKPRLRT VHSGLDDCRP LTKKWRGMKW KKWSIHIVIP KGTFKPPCED
EIDEFLKKLG TSLKPDPVPR DYRKCCFCHE EGDGLTDGPA RLLNLDLDLW VHLNCALWST
EVYETQAGAL INVELALRRG LQMKCVFCHK TGATSGCHRF RCTNIYHFTC AIKAQCMFFK
DKTMLCPMHK PKGIHEQELS YFAVFRRVYV QRDEVRQIAS IVQRGERDHT FRVGSLIFHT
IGQLLPQQMQ AFHSTKALFP VGYEASRLYW STRYANRRCR YLCSIEEKDG RPVFVIRIVE
QGHEDLVLSD TSPKGVWDKI LEPVACVRKK SEMLQLFPAY LKGEDLFGLT VSAVARIAES
LPGVEACENY TFRYGRNPLM ELPLAVNPTG CARSEPKMSA HVKRFVLRPH TLNSTSTSKS
FQSTVTGELN APYSKQFVHS KSSQYRRMKT EWKSNVYLAR SRIQGLGLYA ARDIEKHTMV
IEYIGTIIRN EVANRKEKLY ESQNRGVYMF RMDNDHVIDA TLTGGPARYI NHSCAPNCVA
EVVTFERGHK IIISSNRRIQ TGEELCYDYK FDFEDDQHKI PCHCGAVNCR KWMN
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