ID H0UYQ5_CAVPO Unreviewed; 908 AA.
AC H0UYQ5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=RNA binding motif protein 27 {ECO:0000313|Ensembl:ENSCPOP00000002276.3};
GN Name=RBM27 {ECO:0000313|Ensembl:ENSCPOP00000002276.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000002276.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000002276.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000002276.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in the turnover of nuclear polyadenylated
CC (pA+) RNA. {ECO:0000256|ARBA:ARBA00043866}.
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DR EMBL; AAKN02009999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02010000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02010001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0UYQ5; -.
DR STRING; 10141.ENSCPOP00000002276; -.
DR Ensembl; ENSCPOT00000002531.3; ENSCPOP00000002276.3; ENSCPOG00000002498.4.
DR VEuPathDB; HostDB:ENSCPOG00000002498; -.
DR eggNOG; KOG2135; Eukaryota.
DR GeneTree; ENSGT00510000046929; -.
DR HOGENOM; CLU_006190_0_0_1; -.
DR InParanoid; H0UYQ5; -.
DR OMA; CPMEHGL; -.
DR TreeFam; TF319253; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000002498; Expressed in testis and 12 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR002483; PWI_dom.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR045137; RBM26/27.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR14398; RNA RECOGNITION RRM/RNP DOMAIN; 1.
DR PANTHER; PTHR14398:SF1; RNA-BINDING PROTEIN 27; 1.
DR Pfam; PF01480; PWI; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF00642; zf-CCCH; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00723}.
FT DOMAIN 271..299
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 539..613
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT ZN_FING 271..299
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 77..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 697..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 863..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 735..809
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 86..141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..179
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..354
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..375
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..725
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 874..900
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 908 AA; 102421 MW; C285D5FAC869B031 CRC64;
MLIEDVDALK SWLAKLLECD ADPSALANYV VALVKKDKPE KELKAFCADQ LDVFLQKETS
GFVDKLFESL YTKNYLPPLE PVKPEPKPLV QEKEEIKEEV FQEPAEEERD GRKKKYPSPQ
KARSESSERR TREKKREDGK WRDYDRYYER NELYREKYDW RRGRSKSRSK SRGLSRSRSR
SRGRSKDRDP NRNVEHRERS KFKSERNDLE SSYVPVSAPP PSSSEQYSSG AQSIPSTVTV
IAPAHHSENT TESWSNYYNN HSSSNSFGRN PPPKRRCRDY DERGFCVLGD LCQFDHGNDP
LVVDEVALPS MIPFPPPPPG LPPPPPPGML MPPMPGPGPG PGPGPGPGPG PGHSMRLPVP
QGHGQPPPSV VLPIPRPPIS QSSLINSRDQ PGTSAVPNLT PVGARLPPPL PQNLLYTVSE
HTYEPDGYNP EAPSITSSGR SQYRQFFSRT QTQRPNLIGL TSGDMDANPR AANIVIQTEP
PVPVSINSNI TRVVLEPDSR KRAVSGLEGP LTKKPWLGKQ GNNNQSKPGF LRKNQYTNTK
LEVKKIPQEL NNITKLNEHF SKFGTIVNIQ VAFKGDPEAA LIQYLTNEEA RKAISSTEAV
LNNRFIRVLW HRENNEQPAL QSPTQLLLQQ QQTLSHLSQQ QHHLPQHLHP QQALVGQAST
SSVHGGIQKM MSKPQTSVPV KHRLGHASAN QIDTAGEDCQ IFSPPGHPKT TYSSSNLKTS
SKLCTGSKSH DVQEVLKKKQ EAMKLQQDMR KKRQEVLEKQ IECQKMLISR LEKNKNMKPE
ERANIMKTLK ELGEKISQLK DELKTSSTVS TPSKVKTKTE VSTLSNIFSN VDVFKLLRIL
QIKIAANQGS KFKDRRLQIS WHKPKVPSIS TETEEEEVKE EETETSDLFL HDDDDEDEDE
YESRSWRR
//
