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Database: UniProt
Entry: H0V903_CAVPO
LinkDB: H0V903_CAVPO
Original site: H0V903_CAVPO 
ID   H0V903_CAVPO            Unreviewed;       980 AA.
AC   H0V903;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   24-JAN-2024, entry version 88.
DE   SubName: Full=Corin, serine peptidase {ECO:0000313|Ensembl:ENSCPOP00000006276.3};
GN   Name=CORIN {ECO:0000313|Ensembl:ENSCPOP00000006276.3};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000006276.3, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000006276.3}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000006276.3};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC       Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR   EMBL; AAKN02028214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02028215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02028216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02028217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02028218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02028219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0V903; -.
DR   STRING; 10141.ENSCPOP00000006276; -.
DR   Ensembl; ENSCPOT00000007026.3; ENSCPOP00000006276.3; ENSCPOG00000006957.4.
DR   VEuPathDB; HostDB:ENSCPOG00000006957; -.
DR   eggNOG; KOG3577; Eukaryota.
DR   eggNOG; KOG3627; Eukaryota.
DR   GeneTree; ENSGT00940000157103; -.
DR   HOGENOM; CLU_010853_0_0_1; -.
DR   InParanoid; H0V903; -.
DR   OMA; HCSREQT; -.
DR   TreeFam; TF351678; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000006957; Expressed in heart and 8 other cell types or tissues.
DR   GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:Ensembl.
DR   GO; GO:0007565; P:female pregnancy; IEA:Ensembl.
DR   GO; GO:0016486; P:peptide hormone processing; IEA:Ensembl.
DR   GO; GO:0035813; P:regulation of renal sodium excretion; IEA:Ensembl.
DR   GO; GO:0003050; P:regulation of systemic arterial blood pressure by atrial natriuretic peptide; IEA:Ensembl.
DR   CDD; cd07445; CRD_corin_1; 1.
DR   CDD; cd07888; CRD_corin_2; 1.
DR   CDD; cd00112; LDLa; 7.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 2.
DR   Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 7.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR   InterPro; IPR017052; Corin.
DR   InterPro; IPR041762; Corin_CRD_1.
DR   InterPro; IPR041763; Corin_CRD_2.
DR   InterPro; IPR020067; Frizzled_dom.
DR   InterPro; IPR036790; Frizzled_dom_sf.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR017448; SRCR-like_dom.
DR   InterPro; IPR036772; SRCR-like_dom_sf.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   PANTHER; PTHR24252:SF8; ACROSIN; 1.
DR   PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR   Pfam; PF01392; Fz; 2.
DR   Pfam; PF00057; Ldl_recept_a; 6.
DR   Pfam; PF15494; SRCR_2; 1.
DR   Pfam; PF00089; Trypsin; 1.
DR   PIRSF; PIRSF036376; Corin; 2.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00063; FRI; 2.
DR   SMART; SM00192; LDLa; 7.
DR   SMART; SM00202; SR; 1.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF63501; Frizzled cysteine-rich domain; 2.
DR   SUPFAM; SSF57424; LDL receptor-like module; 7.
DR   SUPFAM; SSF56487; SRCR-like; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR   PROSITE; PS50038; FZ; 2.
DR   PROSITE; PS01209; LDLRA_1; 2.
DR   PROSITE; PS50068; LDLRA_2; 7.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00124}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022825};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Protease {ECO:0000256|ARBA:ARBA00022825};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT   TRANSMEM        48..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          72..194
FT                   /note="FZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50038"
FT   DOMAIN          385..508
FT                   /note="FZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50038"
FT   DOMAIN          737..970
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
FT   ACT_SITE        778
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036376-50"
FT   ACT_SITE        827
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036376-50"
FT   ACT_SITE        920
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036376-50"
FT   DISULFID        151..175
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT   DISULFID        212..230
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        224..239
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        241..253
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        248..266
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        260..275
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        285..303
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        297..312
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        322..340
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        334..349
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        437..475
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT   DISULFID        464..505
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT   DISULFID        468..492
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT   DISULFID        515..527
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        522..540
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        534..549
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        572..587
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        590..602
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        597..615
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        609..624
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ   SEQUENCE   980 AA;  109228 MW;  40082C8EC2153710 CRC64;
     MFTKQCPGLA PEERYRPSGA PKRVLGVDDN NVGDGCSQKL AAVNLLRFLL LVLIPCICAL
     VVLLVILLCL VGACVTVTHS QCQMLPYHTT LTSPVSTIVN VETEKFLKFF TYLHRLSCYK
     YIMLFGCSLA FPECIIDGDD RHGLQPCRSF CEAAKEGCEP VLEMVNASWP NFLKCSQFRN
     QTESSNISRI CFSPQQGNGK QLLCGGGDHF LCTSGICIPR TLQCNGYNDC DDWSDETHCN
     CTVDLFRCHT GKCLNYSFVC DGYDDCGDLS DEQNCDCDPT KEHRCGDGRC ISVEWVCDGD
     HDCVDKSDEV NCSCHSQGLV ECGNGQCIPS AFQCDGDEDC RDASDERNCS APQTPCQEGD
     QRCLFSSCLD SCGGSSLCDP DNGLNNCSQC EPITLELCMN LPYNHTKYPN YLGHRTQKEA
     SISWESSLFP ALVPTNCYKY LMFFACTILV PKCDVTTSQR IPPCRALCEH SKERCESVLG
     IVGLQWPEDT DCSQFPEENS DNQTCLMPDE DVEECSPSHF KCHSGGCVLA FRRCDGQADC
     DDDSDEENCG CKERDLWECP SNKQCLKHSV ICDGFPDCPD NMDEKNCSFC QDDEVECANH
     KCVSRELWCD GEADCSDSSD EWNCVTLSKT MNSSALLYVH RSATEHHVCA DGWQETLSQL
     ACRQMGLGEP SLTESIPEEE ENQQWLRLRS DWKNVSGTAL HRLLVPGQAC PSRNKISLLC
     TKEDCGRRPA ARMNKRILGG RTSRPGRWPW QCSLQSEPSG HICGCVLIAK KWVLTVAHCF
     EGRENSAMWK VVLGINNLDH PSTYTQTRLV KTIILHPRYS RAVVDYDISI VELNEDINET
     SYVRPICLPS PGQALEPDTY CYITGWGHMG NKMPFKLQEG EVRIISLEQC QSYFDMKTIT
     TRMICAGYES GTVDSCMGDS GGPLVCEQPG GQWTLFGLTS WGSICFSKVL GPGVYSNVSY
     FVGWIEKQIY IQTFLPRKKG
//
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