ID H0V964_CAVPO Unreviewed; 2208 AA.
AC H0V964;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=A-kinase anchoring protein 6 {ECO:0000313|Ensembl:ENSCPOP00000006342.3};
GN Name=AKAP6 {ECO:0000313|Ensembl:ENSCPOP00000006342.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000006342.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000006342.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000006342.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02027171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02027172; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02027173; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02027174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02027175; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02027176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02027177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02027178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02027179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000006342; -.
DR Ensembl; ENSCPOT00000007100.3; ENSCPOP00000006342.3; ENSCPOG00000007031.4.
DR VEuPathDB; HostDB:ENSCPOG00000007031; -.
DR eggNOG; ENOG502QSMH; Eukaryota.
DR GeneTree; ENSGT00810000125473; -.
DR HOGENOM; CLU_231193_0_0_1; -.
DR InParanoid; H0V964; -.
DR OMA; PECFFEA; -.
DR TreeFam; TF105405; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000007031; Expressed in heart left ventricle and 9 other cell types or tissues.
DR GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0016529; C:sarcoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0044325; F:transmembrane transporter binding; IEA:Ensembl.
DR GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR GO; GO:1901381; P:positive regulation of potassium ion transmembrane transport; IEA:Ensembl.
DR GO; GO:0060306; P:regulation of membrane repolarization; IEA:Ensembl.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 2.
DR InterPro; IPR026696; AKAP6/CEP68.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR14514:SF2; A-KINASE ANCHOR PROTEIN 6; 1.
DR PANTHER; PTHR14514; PKA ANCHORING PROTEIN; 1.
DR Pfam; PF00435; Spectrin; 1.
DR SMART; SM00150; SPEC; 3.
DR SUPFAM; SSF46966; Spectrin repeat; 3.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT REGION 182..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1122..1164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1745..1814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2054..2208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..396
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1757..1801
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2055..2095
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2123..2142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2157..2174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2208 AA; 244471 MW; 2433A28F451B6D6A CRC64;
EDISDHVEQI HALLETEFSL KLLSYSVNVI VDIHAVQLLW HQLRVSVLVL RERILQGLQD
ANGNYTRQTD ILQAFSEETK EGRLDSLTEV DDSGQLTIKC SQNYLSLDCG ITAFELSDYS
PSEDLLGGLG DMTSSQVKTK PFDSWNYSEM EKEFPELIQS VGLLTVAADS VPSNCSEAVS
EEAFQGSLSA EDKDGDEENS ASAVKEQAGL ISGMSSSGEA VVCTVQPSSE TVKQESNSSY
PHLGTRSQQP AACENITPKR SIRDCFNYNE DSPTQPTLPK RGLFLKEETL KNDLKGNEGR
KQMADLKPEM SRSTPSLVDP PDRSKLCLVL QSSYPHGPSA ASQSYECLHK VGVGNLENII
KSHIKEISSS LGKLNDCHKE KLRLKKSHKT SDEVPPGRTP KRGTSSGKQT GNTKSPVVLN
GMPSSTPKAT EGQEADSAST SSVEPCNQRS RNAKLPVQSE TSSSPPFTQS SDSSVDSDNI
MSPIPLVSKH KNKKGHSSSP SHITKNGQVV EAWYGSDEYL ALPSHLKQTE VLALKLENLT
KLLPQKPKGE SIQNIDDWEL SEMNSDSEIY PMYHVKKKHT RLGRVSPSSS SDIASSLGES
IESGPLSDIL SDEELCMPHS VMKKCIDEKS GRTSSSEKNE SHSATKSALI QKLMQDIQHQ
DNYEAIWEKI EGFVNKLDEF IQWLNEAMET TENWTPPKAE TDSLKLYLET HLSFKLNVDS
HCALKEAVEE EGHQLLELIA SHKAGLKDML QMIASQWKEL QRQIKRQHSW ILRALDTIKA
EILATDVSVE DEEGTGSPKT EVQLCYLEAQ RDAVEQMSLK LYSEQYTSSS KRKEEFADMS
KVHSVGSNGL LDFDSDYQEL WDWLIDMESL VMDSHDLMMS EEQQQHLYKR YSVEMSIRHL
KKTELLSKVE ALKKGGVLLP NDLLEKVDSI NEKWELLGKT LREKIQDTMV GHSGSGPRDL
LSPESGSLVR QLEVRIKELK GWLRDTELFI FNSCLRQEKE GTMNAEKQLQ YFKSLCREIK
QRRRGVASIL RLCQHLLDDR ETCNLSADHQ PMQLIIVNLE RRWEAIVMQA VQWQTRLQKK
MGRESETLNV IDPGLMDLNG MNEDALEWDE TDISNKLISL NEESTDLDQE PQPVIPSLKC
EETSNEDPGY EEGTGDHGGS QYSSNITAPC SPHIYQVYSL HNIELYEDNH LPFLKNNPNF
TSMTQPSVLT KSLSKDSSFS STKSLPDILG GPNLVKPCPC HSGDMCQNSG SESGIVSEGD
TEMTTNSEMC LLSAVDGPPS HPGHLDSQVG DAVNVLKQKF IDEDKCCKPP NSSQSSISPV
GSVNGKVGDL NSVTKHTPDC LGEELQGKHD VFTFYDYSYL QGSKLKLPMI MKQSQSEKTH
VADHLLCGFY FDKKSCKSKQ QALELQPDAP PHEKVLANAP HEMDRSSYKS GDIEKAFAGI
PNAKQFSLLS RSSSIESLSP GSDLFGLGVF KNGSDSLQRS TSLESWLTSY KSNEDLFSCH
SSGDISVSSG SVGELSKRTL DLLNRLENIQ SPSEQKIKRS VSDITLQSSS QKMSYAGQMS
LDIASSINED SAASLTELSS SDELSLCSED IVLHKNKIPE SNASFRKRLN HSVADESDVN
VSMIVNVSCT SACTDDEDDS DLLSSSTLTL TEEELCIKDE DDDSSIATDD EIYEECNLMS
GLDYIKNELQ TWIRPKLSLT RDKKRCNLSE EIKGNKDVSS NEVTNSSDTL NIETLLNDSI
KCLSENNGNS KNSPHMHELG TKSENKKNIF KVNKDPHVAD MENGNIESTP EEPKDKLSES
SHSSENLSSS GKKIPESELC KYKASIDGSD DLNIAGKEFG PPNVRHLPKD CANHHPFENQ
RANCTAITKA CPELSLEARV NNRQVCDVSK SSSNDTSSVD ENSAGCCPAL EPNETEETSS
ISGSVSCCNC KPDVFHQKHA EDCSVHDFVK EIIDMASTAL KSKSQPENEV PAPTSLTQIK
EKVLEHSHRP IHLRKGDFYS YLSLSSHDSD CGEVTSYIEE KSNTPLLLDT IDSGLDEKED
IECFFEACVE NDPNSEDPCF SNTPPDESSV PEETKVPLQA TPHSSKFSDT SLLVNDTDMV
PLPIPPSQKE ADIRKEVDDF PQTSSRYAEN SEFIPSQVHS EKENSGKPGE SGVPEEHNTA
SAKSKVQDLS LKANQLKDKT PLHPSPKSLT CEENLLDLSA EPHGNMHT
//
