ID H0VAA7_CAVPO Unreviewed; 2205 AA.
AC H0VAA7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Collagen type VI alpha 6 chain {ECO:0000313|Ensembl:ENSCPOP00000006780.3};
GN Name=COL6A6 {ECO:0000313|Ensembl:ENSCPOP00000006780.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000006780.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000006780.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000006780.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Collagen VI acts as a cell-binding protein.
CC {ECO:0000256|ARBA:ARBA00043858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the type VI collagen family.
CC {ECO:0000256|ARBA:ARBA00044000}.
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DR EMBL; AAKN02012973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02012974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSCPOT00000007585.3; ENSCPOP00000006780.3; ENSCPOG00000007512.4.
DR VEuPathDB; HostDB:ENSCPOG00000007512; -.
DR GeneTree; ENSGT00940000155619; -.
DR HOGENOM; CLU_001732_0_0_1; -.
DR TreeFam; TF318242; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000007512; Expressed in heart left ventricle and 6 other cell types or tissues.
DR CDD; cd01472; vWA_collagen; 4.
DR CDD; cd01450; vWFA_subfamily_ECM; 3.
DR Gene3D; 1.20.5.320; 6-Phosphogluconate Dehydrogenase, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 8.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR22588:SF5; COLLAGEN ALPHA-6(VI) CHAIN; 1.
DR PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR Pfam; PF01391; Collagen; 3.
DR Pfam; PF00092; VWA; 8.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00327; VWA; 9.
DR SUPFAM; SSF53300; vWA-like; 9.
DR PROSITE; PS50234; VWFA; 9.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 20..199
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 222..400
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 429..599
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 615..784
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 802..975
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 993..1164
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1180..1372
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1745..1900
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1953..2154
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1412..1706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2205 AA; 240379 MW; C7D7937158725573 CRC64;
ILKLLCCTYL FIGPDPEYAD VVFLVDSSDH LGTKSFPLVK MFINKVISSL PIEASKYRVA
LAQYSDTLHS EFHLNTFRSR NPMLNHLKKN FGFIGGPLKI GKALQEAHKT YFSAPTNGRD
KTQFPPILVV LASAESEDDV EEASNALRKD GVKIISVGMQ EASEENLKAM ATSQFHFNLR
TARDLSTFSQ NMTQIIKDVT KHREVTVNDI RVEVCQGPSV ADLVFLLDVS VNGSQENFDY
LKAFLEESVS ALDIKESCMR VGLVTYSNET KVISSLSVGT NKSEVLQQIQ SLSPQAGQAY
TGAAIRKVRK EVFTPQHGSR KNQGVPQIVV LVTHRASEDN VTKAAVNLRR QGVTIFTMGV
DKASTAQLEK IASHPAEQYV SMLGSFTELA AHNVTFLKKL RNQITRTVSV LAERTESLKS
GCVDTEEADI YLLIDGSGST QVTDFHEVKN FLSEVVGMFN IAPHKVRVGA VQYADGWDLE
FEINKYSNKH DLGKAIENIR QMGGNTNTGA ALNFTLGLLQ RAKKERGNKV PCHLVVLTNG
ASKDSVLEPA FRLREENIRV YAIGVKEANH TQLREIAGEE KRVYYVHDFD ALKDIRNQVV
QEICTEGACK DMKADIMFLV DSSGSIGPEN FSKMKMFMKN LVSKSQIGAD RVQIGVVQFS
DVNKEEFSLN RFRSQSDISN AIDRMAHIGE TTLTGSALTF VSQYFSPAKG ARPNVRKFLI
LITDGEAQDI VKDPADALRQ EGIIIYSVGV FGSNVTQLEE ISGKREMVFY VENFDILKHI
EDDLVFGICS PHEECKRIEV LDVVFVIDSS GSIDYDEYNI MKDFMIGLVK KADVGKNQVR
FGAMKYADDP EVLFYLDDLG TKLEVISALQ GDQPMGGNTY TAEALAFADH MFTEARGSRL
HKGVPQVLIV ITDGESHDAE KLNATSQALR EKGILVLAVG IAGANPVELL AMAGSSDKYY
FVETFGGLKG IFSDVSASVC NTSKVDCDIK NVDLVFLMDG SNSIHPSDFK KMKEFLASVV
QDFDVSLKTV RIGAAQFSDS YRPEFSLGAF AGEKEISFQI ENIQQIFGYT HLGAALQKVS
QYFQPDMGSR INTGTPQVLL VLTDGRSQDE VAQAAEELRH KGVDIYSVGI GDVDDQQLIQ
ITGTADKKLT VHNFDELKKV KKRIVRHICN SGGESNCFVD VVVGFDISTQ LEGQTLLTDQ
PWMGTYLQNL LRAISSLNGV SCEVGTETQV SVAFQVTNAM EKYSPKFEIY SENILDSLKD
LRVKGPSHLD VNLLSALWDA FQNKSVARGK VALIFSDGLD DDTEKLEQKS DELRKEGLNA
LITVALDGAA HSGDLADLLY IEFGKGFEYR TQFSIGMRDL GTQLSKQLIN VAERTCCCLF
CKCIGGDGMM GDPGTSGKKG LTGFKGSEGY LGEDGIAGER GAPGPVGEQG TKGCHGTKGP
KVRTGEVGEL GVDGLNGEQG ETGLPGRKGE KGDAGFQGSP GKRGSKGDHG AKGLRGDPGI
PGFDNSIQGP KGLKGERGRQ GRRGWPGPSG TPGSRRRTTA HGRRGQTGPQ GNTGIPGPDG
IEGSLGLKGP QGPRGEVGAK GEKGSLGMKG PQGPPGPGGE VGNQGHSGSQ GYKGEPGDPG
EKGAIGFPGP RGLPGDDGNP GYGSVGRNGA KGQEGFPGES GTKGDMGDPG DPGEAGQKGV
KGKTISAGLP GEPGSPGEPG PVGRKGVKGA KGLASFSTCE LIQYVQDHTY ACLLGKPQCP
VHPTELVFAL DQSRDVTEQD FERMKGMVAS LVRDMKIRES SCPTGARVAI LTYGSYARHL
VRFSDAYRKD QLLREIAAIP YEKSLDSRET GKAMRFISRN VFKRTLPGAH TRRIATFFSG
GQSADIQSIT TATMEFGALD ITPVVIAFSN VPSIRRVFSI DDTGTFQVIV IPSGTDDKPA
LERLQRCTFC YDMCRPDTSC DQDRPLPAES YMDAAFLLDG SRNVGSAEFE DIRGFLGALL
EHFEITPEPT TSVTGDRVAL LSHAPPNFLP NTQRSPVRTE FNLTTYSNKR LMKRHVEQSV
QQLNGDAFVG HALRWTLDNV FLSTPNLRKN KVIFVISAGE TSYLDGETLR QESLRAKCQG
YALFVLSLGP AWNDKELEDL ASHPLDHHLI QLGRIHKPDH RYGVKFVKSF INSVRRAINK
YPPINLKAKC NRISPTASRQ TPRLFRRYQP LHIFFKKKKL ESLLK
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