ID H0VCB5_CAVPO Unreviewed; 1010 AA.
AC H0VCB5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Integrin subunit alpha 6 {ECO:0000313|Ensembl:ENSCPOP00000007567.3};
GN Name=ITGA6 {ECO:0000313|Ensembl:ENSCPOP00000007567.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000007567.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000007567.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000007567.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; AAKN02005644; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02005645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02005646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VCB5; -.
DR Ensembl; ENSCPOT00000008493.3; ENSCPOP00000007567.3; ENSCPOG00000008418.4.
DR VEuPathDB; HostDB:ENSCPOG00000008418; -.
DR GeneTree; ENSGT00940000155353; -.
DR HOGENOM; CLU_004111_1_0_1; -.
DR TreeFam; TF105391; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000008418; Expressed in zone of skin and 12 other cell types or tissues.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF9; INTEGRIN ALPHA-6; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR Pfam; PF00357; Integrin_alpha; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 950..974
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 40..105
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 240..302
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 303..358
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 402..561
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 563..728
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 734..940
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1010 AA; 112646 MW; 6B0AAEB6EDE1AE96 CRC64;
LLVGAPRAKA LPRQRANRTG GLYSCDITSR GPCTRIEFDN DADPASESKE DQWMGVTVQS
QGPGGKVVTC AHRYEKRQHV NTKQESRDIF GRCYVLSQNL RIEDDMDGGD WSFCDGRLRG
HEKFGSCQQG VAATFTKDFH YIVFGAPGTY NWKGIVRVEQ KNNTFFDMNI FEDGPYEVGG
ETDHDESLVP VPANSYLGFS LDSGKGIVSK DEITFVSGAP RANHSGAVVL LKRELKSAHL
LPEHIFDGEG LASSFGYDVA VVDLNKDGWQ DIVIGAPQYF DRDGEIGGAA YVYINQQGRW
NNVKPIRLNG TKDSMFGIAV KNIGDINQDG YPDIAVGAPY DDMGKVFIYH GSANGINTKP
TQVLEGTTPS FGYSIAGNMD LDRNSYPDVA VLPSQISSIF RSRPVINIQK TITVTPSRID
LRQKTCAAPS GICLKVKACF EYTAKPTGYN PPITIVGTLE AEKQRRKSGL SSRVQFRNQA
SEPRYTQELT LQRQKQRLCM EETLWLQENI RDKLRPIPIT ASVEIQEPSS RRRVNSLPEI
LPILNSNEPT TVQTDVHFLK EGCGDDNVCN SNLKLEYKFC TREGNQDKFS YLPIQKGVPE
LVLKDQKDIA LEITVTNIPS DPRNPKKDGD DAHEAKLIAT FPDTLTYSAY RELRAFPEKQ
LSCVANQNGS QADCELGNPF KRNSSVTFYL ILSTTELTFD TTDLDINLKL ETTSNQDNLA
SITAKAKVVI ELLLSVSGVA KPSQVYFGGT VVGEQAMKSE DEVGSLIEYE FKVINLGKPL
KNLGSATLNI QWPKEISNGK WLLYLVKVES KGLEKIVCEP PDEINPLKLK ESHKSRMKRE
IAEKQIDDRR KFSLFTERKY QTLNCSVNVK CVNIRCPLQG LDSKAALVLR SRLWNGTFLE
EYSKMNYLDI LVRAYIEVTA AAGNIKLPHA GTQVRVTVFP SKTVAQYSGI PWWVILVSIL
AGILMLALLV IVLWKCGFFK RNKKDHYDAT YHKAEIHAQP SDKERLTSDA
//
