ID H0VG81_CAVPO Unreviewed; 1128 AA.
AC H0VG81;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Tripartite motif containing 33 {ECO:0000313|Ensembl:ENSCPOP00000009104.2};
GN Name=TRIM33 {ECO:0000313|Ensembl:ENSCPOP00000009104.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000009104.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000009104.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000009104.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02004619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02004620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02004621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02004622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02004623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02004624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02004625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003479300.1; XM_003479252.3.
DR AlphaFoldDB; H0VG81; -.
DR STRING; 10141.ENSCPOP00000009104; -.
DR Ensembl; ENSCPOT00000010231.3; ENSCPOP00000009104.2; ENSCPOG00000010140.4.
DR GeneID; 100719836; -.
DR CTD; 51592; -.
DR VEuPathDB; HostDB:ENSCPOG00000010140; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000156361; -.
DR HOGENOM; CLU_005817_0_0_1; -.
DR InParanoid; H0VG81; -.
DR OMA; ICQNCVM; -.
DR OrthoDB; 56754at2759; -.
DR TreeFam; TF106455; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000010140; Expressed in testis and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0070410; F:co-SMAD binding; IEA:Ensembl.
DR GO; GO:0070412; F:R-SMAD binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
DR GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR CDD; cd19847; Bbox1_TIF1g_C-VI; 1.
DR CDD; cd19830; Bbox2_TIF1g_C-VI; 1.
DR CDD; cd05502; Bromo_tif1_like; 1.
DR CDD; cd15624; PHD_TIF1gamma; 1.
DR CDD; cd16766; RING-HC_TIF1gamma; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR003649; Bbox_C.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR45915:SF3; E3 UBIQUITIN-PROTEIN LIGASE TRIM33; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00502; BBC; 1.
DR SMART; SM00336; BBOX; 2.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00184; RING; 2.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50119; ZF_BBOX; 2.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 126..186
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 213..260
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 272..313
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 888..935
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 975..1047
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1089..1128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 310..391
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 101..117
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..772
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1107..1128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1128 AA; 122713 MW; BA4709D5AD17A571 CRC64;
MAENKGGGEA ESGGGGSGSA PVTAGAAGPA AQEAEPPLAA VLVEEEEEEE GSRAGAEGGA
AGPDDGGVAA ASSGSAPAAS APAASVGPGV PGGAVSTPAP APASAPAPGP SSGPPLGPPA
SLLDTCAVCQ QSLQSRREAE PKLLPCLHSF CLRCLPEPER QLSLPIPGSS NGDVHQVGVI
RCPVCRQECR QIDLVDNYFV KDTSEAPSSS DEKSEQVCTS CEDNASAVGF CVECGEWLCK
TCIEAHQRVK FTKDHLIRKK EDVSESVGAS GQRPVFCPVH KQEQLKLFCE TCDRLTCRDC
QLLEHKEHRY QFLEEAFQNQ KGAIENLLAK LLEKKNYVHF AATQVQNRIK EVNETNKRVE
QEIKVAIFTL INEINKKGKS LLQQLENVTK ERQMKLLQQQ NDITGLSRQV KHVMNFTNWA
IASGSSTALL YSKRLITFQL RHILKARCDP VPAANGAIRF HCDPTFWAKN VVNLGNLVIE
SKPAPGYTPN VVVGQVPPGT NHISKTPGQI NLAQLRLQHM QQQVYAQKHQ QLQQMRMQQP
PAPAPPPTTT TQQHPRQTAP QMLQQQPPRL ISVQTMQRGN MNCGAFQAHQ MRLAQNAARI
PGIPRHSGPQ YSMMQPHLQR QHSNPGHAGP FPVVSVHNTT INPTSPTTAT MANANRGPTS
PSVTAIELIP SVTNPENLPS LPDIPPIQLE DAGSSSLDNL LSRYISGSHL PPQPTSTMNP
SPGPSALSPG SSGLSNSHTP VRPPSTSSTG SRGSCGSSGR TTEKTGLSFK SDQVKVKQEP
GTEDEVCSFS GAVKQEKTED GRRSACMLSS PESSLTPPLS TNLHLESELD ALASLENHVK
SEPADMNESC KQSGLSNLVN GKSPIRSLIH RSARIGGDGN NKDDDPNEDW CAVCQNGGDL
LCCEKCPKVF HLTCHVPTLL SFPSGDWICT FCRDIGKPEV EYDCDNLQHS KKGKTVQGLS
PVDQRKCERL LLYLYCHELS IEFQEPVPAS IPNYYKIIKK PMDLSTVKKK LQKKHSQHYQ
IPDDFVADVR LIFKNCERFN EMMKVVQVYA DTQEINLKAD SEVAQAGKAV ALYFEDKLTE
IYSDRTFAPL PEFEQEEDDG EVTEDSDEDF IQPRRKRLKS DERPVHIK
//
