ID H0VS80_CAVPO Unreviewed; 923 AA.
AC H0VS80;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN Name=LOC100727821 {ECO:0000313|Ensembl:ENSCPOP00000013473.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000013473.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000013473.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000013473.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CLCR family.
CC {ECO:0000256|ARBA:ARBA00006398}.
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DR EMBL; AAKN02004826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VS80; -.
DR STRING; 10141.ENSCPOP00000013473; -.
DR Ensembl; ENSCPOT00000015096.3; ENSCPOP00000013473.3; ENSCPOG00000014950.4.
DR VEuPathDB; HostDB:ENSCPOG00000014950; -.
DR eggNOG; ENOG502QRRD; Eukaryota.
DR GeneTree; ENSGT00940000160416; -.
DR HOGENOM; CLU_005812_0_1_1; -.
DR InParanoid; H0VS80; -.
DR OMA; RQFTECE; -.
DR TreeFam; TF328396; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00198; vWFA; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR004727; CLCA_chordata.
DR InterPro; IPR013642; CLCA_N.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR NCBIfam; NF041940; choice_anch_X; 1.
DR NCBIfam; TIGR00868; hCaCC; 1.
DR PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR PANTHER; PTHR10579:SF2; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR 4; 1.
DR Pfam; PF08434; CLCA; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00023049};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..923
FT /note="VWFA domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013356841"
FT TRANSMEM 885..910
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 307..477
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 923 AA; 101033 MW; 3A6CA0E65A1AC442 CRC64;
TMGLFRALVP LLVLHLLGGS NASLVQLKDN GYEDIIVAID PDVPEDGEII EHIKDMVSTA
STYLFEATEK RFFFKTVSIL IPETWDANPE YKRPKHESYK HADVIVAPPT LPNRDEPYTR
QFTECGEKAE YIHFTPDFVL GKKENEYGPS GRLLVHEWAH LRWGVFDEYN EDQPYYSAKS
KKIEATRCSA GISGRNSVHK CQGGSCSTRS CKINPTTKLY EKDCQFFPDK VQTEKASIMF
MQSIDSVVEF CNEKNHNQEA PSLQNLKCNY RSTWEVIRES EDFTNTTAME TPPPPPTFSL
LRIRDRIVCL VLDKSGSMSA GSRLTRMNQA AKLFLMQTVE NGSWVGMVHF DSTASIKSEL
IQVRSNTERD TLVKSLPTYA NGGTSICSGI AKAFEVIRKV DPQLDGSEIV LLTDGEDNTA
KNCVNEVTES GVIIHLIALG PSADPAVTQM SNQTGGNHYY ASDNAENNGL IDAFAALTSE
NVGLSQKSIQ LESKGLNLNT SAWMNDTVTV DSTVGKDTFF LVTWTKQPPS ISLWDPNGTL
TANFTQDTVS RMAYLSIPGD AKVGTWIYNL QAKADSETLT ITVTSRAANS AVPPITVSAK
MNKDTNTFPS PMIVYAEVQQ GYVPILGASV TAVIESSNGH TTVLDLLDNG SGADAFKDDG
VYSRYFTGYS ENGRYSLKVR AHAATSSTRR SLKHALSRAA YIPGWVVDGE IEGNPPRPEA
DENTETILEN FSRTASGGAF VVSGYPNTPV TDPYPPSQIT DLAATPEGEE VTLTWTAPGE
NFDVGKVERY IIRISGSMIE LRDNFDAALQ VNTTDLVPKE ANSKETFTFK PGNISEENAT
HIFIAIQSVD KSSLTSKVSN IAQVALFIPE ADPDPEENNS SGVNVFAVVL SVVLSVVVVS
IILSTVICVI KKKNSSAALE HIC
//
