ID H0VT60_CAVPO Unreviewed; 470 AA.
AC H0VT60;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Syncoilin, intermediate filament protein {ECO:0000313|Ensembl:ENSCPOP00000013840.3};
GN Name=SYNC {ECO:0000313|Ensembl:ENSCPOP00000013840.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000013840.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000013840.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000013840.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02028589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013009473.1; XM_013154019.1.
DR AlphaFoldDB; H0VT60; -.
DR STRING; 10141.ENSCPOP00000013840; -.
DR Ensembl; ENSCPOT00000015504.3; ENSCPOP00000013840.3; ENSCPOG00000015355.4.
DR GeneID; 100727678; -.
DR CTD; 81493; -.
DR VEuPathDB; HostDB:ENSCPOG00000015355; -.
DR eggNOG; ENOG502RKZJ; Eukaryota.
DR GeneTree; ENSGT00390000018108; -.
DR HOGENOM; CLU_072232_0_0_1; -.
DR InParanoid; H0VT60; -.
DR OMA; GGMETKS; -.
DR OrthoDB; 5319272at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000015355; Expressed in heart and 12 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
DR GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
DR GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR GO; GO:0045103; P:intermediate filament-based process; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR027702; Syncoilin.
DR PANTHER; PTHR47147; SYNCOILIN; 1.
DR PANTHER; PTHR47147:SF1; SYNCOILIN; 1.
DR Pfam; PF00038; Filament; 1.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 157..452
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 401..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 161..188
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 263..297
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 22..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 470 AA; 53818 MW; 44868236E43AD78B CRC64;
MATPEARSGG DGGPQAGREV TAEAVSQENS ESLSVTETLN PEATLSLEGT VNLEDILYLG
DTDDFEEILY MGDTQEPEEI LYIEETGHPE ETLFMGEPVK PGETQYEETV KPHVDQAESL
SPEQIVCETE TVAREEKSNP EESLKAEPSP STEENLSIED LELLEDRFQQ CVQAVAQLEE
ERDQLIHELV LLREPALQEV QQVHQDILAA YKLHAQTELE RDGLREEIRL VKQKLFKVTK
ECVAYQYQLE CRQQEVAQFA DFREVLTTKA AQLSGELAQL QDAYQKQKEQ LRQQLEAPPS
QRDGHFLQES RQLSAQFEHL MAESRQGLEE EYEPQLLRLL ERKEAGTKAL QKTQAEIQEM
KEALRPLQAE ARQLQLQKRN LEDQITLVRQ KRDEEVQQYR EQQEEMEERK RQLRNGVQLQ
QQKNKDMEQL RISLAEELST YKAMLPKSLE QADALTSQAG GMEKQSQGAA
//
