ID H0VUK9_CAVPO Unreviewed; 907 AA.
AC H0VUK9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=P53-induced death domain protein 1 {ECO:0000313|Ensembl:ENSCPOP00000014383.2};
GN Name=PIDD1 {ECO:0000313|Ensembl:ENSCPOP00000014383.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000014383.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000014383.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000014383.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02056355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013005918.1; XM_013150464.1.
DR RefSeq; XP_013005924.1; XM_013150470.1.
DR RefSeq; XP_013005927.1; XM_013150473.1.
DR AlphaFoldDB; H0VUK9; -.
DR STRING; 10141.ENSCPOP00000014383; -.
DR Ensembl; ENSCPOT00000002875.3; ENSCPOP00000014383.2; ENSCPOG00000002839.4.
DR VEuPathDB; HostDB:ENSCPOG00000002839; -.
DR eggNOG; KOG0619; Eukaryota.
DR eggNOG; KOG4177; Eukaryota.
DR GeneTree; ENSGT00940000161780; -.
DR HOGENOM; CLU_017883_0_0_1; -.
DR InParanoid; H0VUK9; -.
DR OMA; HRDNLGA; -.
DR TreeFam; TF331183; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000002839; Expressed in liver and 13 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:1905369; C:endopeptidase complex; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0004175; F:endopeptidase activity; IEA:Ensembl.
DR GO; GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; IEA:Ensembl.
DR GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0016540; P:protein autoprocessing; IEA:Ensembl.
DR GO; GO:0043122; P:regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR019502; Peptidase_S68_pidd.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF42; LEUCINE RICH REPEATS AND DEATH DOMAIN CONTAINING 1; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF10461; Peptidase_S68; 1.
DR Pfam; PF00791; ZU5; 2.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00364; LRR_BAC; 6.
DR SMART; SM00369; LRR_TYP; 7.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 327..459
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 460..601
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 793..878
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT ACT_SITE 449
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT ACT_SITE 451
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT ACT_SITE 591
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT ACT_SITE 593
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT SITE 450..451
FT /note="Cleavage; by autolysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-2"
FT SITE 592..593
FT /note="Cleavage; by autolysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-2"
SQ SEQUENCE 907 AA; 99850 MW; 0E6EA4C2FFB16F72 CRC64;
MMAAAVEGLE AEEGAAAEDT ARLVVEAADA QPGTSPVLAG NWLNLDLYPG GCHRLLHLCA
QQPSPLLQVE FLQLSTHENP GLLETTLAQV PWSQLRLRSL ILKGGQSRGA LGVCLQGTLT
TLPAGLSGLA FLVHLDLSFN SLETLPACVP QLHGLGSLLL SYNRLSELPE ALGALPTLTF
LAVTHNHLQR LPTALGALVT LKCLDLSENL LDTVPPEIGG LSNLSELNLA SNRLRSLPAS
LAGLQSLQIL VLHSNLLTSV PAGLAHLPLL TRLDLRDNQL QNLPPDLLDT PCVCLEGNPL
GKALPAAPSP PGIPQDLEMP TLFLTSDVDS FPVTPQGCSV TLACGVRLQF PAGATAVPVT
IHYRLWLPEP SLVSLGPNDS LLSGVLELWP HGVAFQQDVS LWLLFVPPRA RRCHEVVVRT
RSEDSWQDLE THLEEEAPKR LWARCQVPHF SWFLVVLRPV SNACLVPPEG TLLCSSGHPE
VKVIFPPGAT EEPCHVSMQV VRIARRELRA LLREPEAAVS PLLCLTQRGP AGFLCPVTVQ
LPLPPGITGF SLDRSHLYLL YRAPPAATWD DITGQVPLEL THLYARFQVT HFSWYWLWYT
TKTCVEGLAR KAWERLRLHQ VNLIALQRRR DPEQVLLQCL PQNKVDATLR RLLERYRGPE
PSDTVEMFEG EKFFAAFERG IEVDADRPDC VEGRICFVFY SHLKNVKEVY ITTSLDREAQ
AVRGQVSFYR GSVPEEVALE AEAARQRKAA DALWMATLPI KLPRLRGSLG HRQGPGLSLV
PLNLGDAETG FLTQSNLLSV ARRLGPDWPA VALHLGLPYQ ELERIRHKFR DDLDGQICHM
LFSWAERQAG QQGAVRCLVQ ALEQSDRQDV ADEVRTILEL GRHKYQDSIR RTGLALEDPA
LPGASTQ
//
