ID H0VWP4_CAVPO Unreviewed; 841 AA.
AC H0VWP4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=KN motif and ankyrin repeat domain-containing protein 2 {ECO:0000256|ARBA:ARBA00040277};
GN Name=KANK2 {ECO:0000313|Ensembl:ENSCPOP00000015122.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000015122.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000015122.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000015122.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
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DR EMBL; AAKN02056467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VWP4; -.
DR STRING; 10141.ENSCPOP00000015122; -.
DR Ensembl; ENSCPOT00000025314.2; ENSCPOP00000015122.2; ENSCPOG00000027433.2.
DR VEuPathDB; HostDB:ENSCPOG00000027433; -.
DR eggNOG; KOG0514; Eukaryota.
DR GeneTree; ENSGT00940000161012; -.
DR HOGENOM; CLU_004269_2_0_1; -.
DR InParanoid; H0VWP4; -.
DR OMA; DTVVQKC; -.
DR TreeFam; TF324499; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000027433; Expressed in uterine cervix and 13 other cell types or tissues.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0072073; P:kidney epithelium development; IEA:Ensembl.
DR GO; GO:0030837; P:negative regulation of actin filament polymerization; IEA:InterPro.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0043069; P:negative regulation of programmed cell death; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0070563; P:negative regulation of vitamin D receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0090521; P:podocyte cell migration; IEA:Ensembl.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:Ensembl.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047184; KANK1-4.
DR InterPro; IPR021939; KN_motif.
DR PANTHER; PTHR24168; KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24168:SF0; KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF12075; KN_motif; 1.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 657..682
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 729..761
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..31
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 841 AA; 89240 MW; 58F884440D0F6FB0 CRC64;
MAQVLHAPAP FPGTPGPTSP PPFPAKEPDP PYSVETPYGY RLDLDFLKYV DDIEKGHTLR
RVAMQRRPRL GSLPRGPGSW WTSTESLCSN ASGDSRHSAY SYCGRGFYPQ YGTLETRSAS
GFNPRVERTL LDARRRLEDQ AAAPSGLGSL TPSAAGSTSS LVGVGLPPPV TPRGSGLSTP
VPPSAGHLAH VREQMAGALR KLRQLEEQVK LIPVLQVKLS VLQEEKRQLA VQLKSQKFLG
HPTGARARGE LCLDLPEPAE DPAALDTRSV GTWVRERDLG LPDGEAALAA KVAVLETQLK
KALQDLQVAQ ARQAEPQPQA WPPPDTPVRV DTVRVVEGPR EVEVAASTTT GAPAQRAQSL
EPYGAGLRAL VTPGDPESPA VFCSHEVVET MCPVPAAPTG NVHVVKKISI TERSCPTRAP
AESSSSSSSS LPASAPENAG RVATADPDDR EPPGEVAPMS QEAGGAGVRS IMKRRQEAAE
PSVHRGNLQF VGVNGGYESS SEGSSTAENF SDNDSTENEA PEPEERAPSP AAAPQRRPSG
TAASVTRPGQ PGCPLSGEAQ RVATAEGAAG TNSEDEIRME LSPDLISACL ALEKYLGNAN
ALTERELKVA HTTVLQEWLR LACRSDAHPE LVRRHLVTFR AMSGRLLDYV VNIADGNGNT
ALHYSVSHAN FPVVRQLLDS GVCQVDRQNR AGYSPLMLTA LATLKTQDDI ETVTQLFRLG
DVNARASQAG QTALMLAVSH GRVDVVKALL ACEADVNVQD DDGSTALMCA CEHGHKDIAG
LLLAVPSCDI SLADRDGSTA LMVALDAGQS EVASMLYSRM NIQCSFAPMS DESPVSSSAE
E
//
