ID H0W2K4_CAVPO Unreviewed; 1286 AA.
AC H0W2K4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Rho GTPase activating protein 33 {ECO:0000313|Ensembl:ENSCPOP00000017197.2};
GN Name=ARHGAP33 {ECO:0000313|Ensembl:ENSCPOP00000017197.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000017197.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000017197.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000017197.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PX domain-containing GAP family.
CC {ECO:0000256|ARBA:ARBA00008795}.
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DR EMBL; AAKN02042170; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSCPOT00000024797.2; ENSCPOP00000017197.2; ENSCPOG00000019450.2.
DR VEuPathDB; HostDB:ENSCPOG00000019450; -.
DR GeneTree; ENSGT00940000155110; -.
DR HOGENOM; CLU_009183_0_0_1; -.
DR TreeFam; TF351451; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000019450; Expressed in frontal cortex and 12 other cell types or tissues.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07299; PX_TCGAP; 1.
DR CDD; cd04384; RhoGAP_CdGAP; 1.
DR CDD; cd11835; SH3_ARHGAP32_33; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15729; CDC42 GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15729:SF11; RHO GTPASE-ACTIVATING PROTEIN 33; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 185..247
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 341..536
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 881..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 965..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1074..1123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1146..1286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..612
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..810
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..908
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 909..925
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..990
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1074..1104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1193..1207
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1286 AA; 137231 MW; B759B50EF944A41D CRC64;
MARSTDSLDG PGEGSVQPVP STGGPSVKGK PGKRLSAPRG PFPRLADCAH FHYENVDFGH
IQLLLSPERE GPSLSGENEL VFGVQVTCQG RSWPVLRSYD DFRSLDAHLH RCIFDRRFSC
LPELPPPPEG ARAAQMLVPL LLQYLETLSG LVDSNLNCGP VLTWMELDNH GRRLLLSEEA
SLNIPAVAAA HVVKRYTAQA PDELSFEVGD IVSVIDMPPT EDRSWWRGKR GFQVGFFPSE
CVELFTERPG PGLKAGKCYG QSGRPPVSSA YNLSLLPVFH PIDADGSLCG IPAPQGNSSL
TSAVPRPRGK LAGLLRTFMR SRPSRQRLRQ RGILRQRVFG CDLGEHLSNS GQDVPQVLRC
CSEFIEAHGV VDGIYRLSGV SSNIQRLRHE FDSERIPELS GPAFLQDIHS VSSLCKLYFR
ELPNPLLTYQ LYGKFSEAMS VLGEEERLVR VHDVIQQLPP PHYRTLEYLL RHLARMARHS
ANTSMHARNL AIVWAPNLLR SMELESVGLG GAAAFREVRV QSVVVEFLLT HVEVLFSDTF
TSAGLDPAGR CLLPRPKSLA GSGPSTRLLT LEEAQARTQG RLGTPTEPTT LKAAASPVEK
RKRERGEKQR KPGGSSWKTF FALGRGPSIP RKKPLPWLGG SRAPPQPSGN RPDTVTLRSA
KSEESLSSQA SGTGLQRLHR LRRPHSSSDA FPVGPAPAGS CETLSSSSSS SSSSSASSSS
SSSESSAAGL GPLSGSPSHR TSAWLDDGDE LDFSPPRCLE GLRGLDFDPL TFRCSSPTPG
DPAPPASPAP PAPASACPPR ATPKAPSPRG PTSPASSTAL DISEPLAVSV PPAVLELLGA
GGTPASVTPT PALSLRPHLI PLLLHGSEAQ LSDTCQQEIS SKLALPGPGG SQGQHVESCS
AHPTLSQTPK LPQDPPDPLP IPFCVGPGID SPLLPPPLSL LRPGGAPPPP PKNAARLMAL
ALAERAQQVA KQQSQQEHAS TSTSPHSPFR RSLSLEVGGE PVVTSGSGPP PHSLAHPGLR
AGGGCRDAPE MAAQSPCSVP SQVPTPSVFS PAPRECLPPF LGVSKPGLYP LAPSSFQPNS
SAQVWRNSLG PPGSPYSGPT RSWSPFRSMP PDRLSASYGM LGQSPPLHRS PDFLLSYPPP
PSCFPPDHLG YSVPQHPARH PTRPEPLYVN LALGPRGPSP ASSCSSSPPA HPRSRSDPGP
PAPRLPQKQR APWGSNTPHR VTGPWGPPEP LLLYRGSPPA YGRGSEHYQG SLYRNGGQRG
EGAGPPPPYL TPSWSLHSEG QTRSYC
//
