ID H0WFL7_OTOGA Unreviewed; 1811 AA.
AC H0WFL7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Sucrase-isomaltase {ECO:0000313|Ensembl:ENSOGAP00000000036.2};
GN Name=SI {ECO:0000313|Ensembl:ENSOGAP00000000036.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000000036.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000000036.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 31 family.
CC {ECO:0000256|ARBA:ARBA00007806}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00779}.
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DR EMBL; AAQR03113960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03113961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03113962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03113963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03113964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03113965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03113966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03113967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03113968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03113969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSOGAT00000000040.2; ENSOGAP00000000036.2; ENSOGAG00000000040.2.
DR GeneTree; ENSGT00940000161633; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0090599; F:alpha-glucosidase activity; IEA:UniProt.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06602; GH31_MGAM_SI_GAA; 2.
DR CDD; cd14752; GH31_N; 2.
DR CDD; cd00111; Trefoil; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 2.
DR Gene3D; 2.60.40.1760; glycosyl hydrolase (family 31); 2.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 4.
DR Gene3D; 4.10.110.10; Spasmolytic Protein, domain 1; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR030458; Glyco_hydro_31_AS.
DR InterPro; IPR048395; Glyco_hydro_31_C.
DR InterPro; IPR030459; Glyco_hydro_31_CS.
DR InterPro; IPR025887; Glyco_hydro_31_N_dom.
DR InterPro; IPR000322; Glyco_hydro_31_TIM.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR000519; P_trefoil_dom.
DR InterPro; IPR044913; P_trefoil_dom_sf.
DR PANTHER; PTHR22762; ALPHA-GLUCOSIDASE; 1.
DR PANTHER; PTHR22762:SF168; P-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13802; Gal_mutarotas_2; 1.
DR Pfam; PF01055; Glyco_hydro_31_2nd; 2.
DR Pfam; PF21365; Glyco_hydro_31_3rd; 2.
DR Pfam; PF00088; Trefoil; 1.
DR SMART; SM00018; PD; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 2.
DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 2.
DR SUPFAM; SSF57492; Trefoil; 1.
DR PROSITE; PS00129; GLYCOSYL_HYDROL_F31_1; 2.
DR PROSITE; PS00707; GLYCOSYL_HYDROL_F31_2; 2.
DR PROSITE; PS51448; P_TREFOIL_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Sulfation {ECO:0000256|ARBA:ARBA00022641};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 917..962
FT /note="P-type"
FT /evidence="ECO:0000259|PROSITE:PS51448"
SQ SEQUENCE 1811 AA; 208180 MW; 3A7C6C23B3C12212 CRC64;
MARKKFSGLE ISLIVLFVIV TIIAIALVAV LATKTPAVEE RIFSKVGKPE FSSVLQKLSK
EIGILKEKIY FQFLSSINSC MWFTKNYLND NFCTISASAP REWNKISQGT RTFKTQLKRI
PSPTVFGGDL DNVLLTTQSQ TVNRFRFKIT DLNNARFKVP HQYIQEFTGP VPSETAYEVQ
VTEIPFSIKV IRKSNRRTLV GSLGDAPILW CNFYNSINTV LPQYPWDIGS NLKMKIKHIK
YKLTFLYLWV RKTITGGQNN NNLYGHQTFF MCIEDTSGKS FGVFLLNSNA MEILIQPTPI
VTYRVIGGIL DFYIILGDTP EQVVQQYQEL VGLPAMPAYW SLGFQLSRWN YGSLDVVKEV
VKRNRDAGIP FDTQVTDIDY MEEKKDFTYD QVAFQGLPEF VQDLHDHGQK YVIILDPAIS
IEKRINGADY ETYDRGSAAG VWVNESDGFT PIIGEVWPGL TVYPDFTNPT CIDWWANECS
IFYQGVKYDG LWIDMNEVSS FIQGSKKGCN ENKLNYPPFT PDILDKLLYS KTICMDSVQT
WGKQYDVHSL YGYSMAIATE KVREKFFLYI FTRKTYSLSI KDIFIFSGTR KKSKLHCNAH
EMPIYKTNQH AKNTVGADIC GFVGETTEEL CRRWMQLGAF YPFSRNHNAD VYQHQDPAFF
GQNSLLVNSS RHYLSIRYTL LPFLYTLFYR AHMFGETVAR PVLHEFYEDT NSWIEDLEFM
WGPALLITPV LRQGVDTVSA YIPDATWYDY ETGAKRPWRK QRVNMYLPAD KIGLHLRGGY
IIPIQEPDVT TTASRKNPLG LIVALDENNA AAGDLFWDDG ETKNTIQSGS YILYRFSASN
NTLNIECTHS GYQEGTTLAF QTIKILGLTD TVTEVLVAEN GQQMAAHRNF TYDPSNQILL
IKNLNFNLGK SFNVQWNQVY SENETFNCYP DADSAPEAEC KQRGCLWRAV SLSKEPECYF
PRQDNPYLVK SMHYSSTGIT ADLELNAANA RIKLPSEPIS TLRVEVKYHK DEMLQFKIYD
PLNKRYEVPV PLNIPTTPTS SHENRLYDVE IKENPFGIQI RRRSSGRVIW DSRLPGFAFN
DQFIQISTRL PSEYIYGFGE VEHTAFKRDL NWNTWGMFTR DQPPGYKLNS YGFHPYYMAL
EEEGNAHGVL LLNSNAMDVT FQPTPALTYR TIGGILDFYM FLGPTPEVAT QQYHEVIGRP
VMPPYWALGF QLCRYGYRNT SQIVEVYEGM VAAQIPYDVQ YTDIDYMERQ LDFTIDDEFS
ELPQFVDRIR GEGMKYIIIL DPAISGNETK PYPAFTRGIE KDVFVKWPNT SDICWAKVWP
DLPNVTIDET ITEDEAVVAS RAHVAFPDFF RNATAGWWER EIIDFYTDQM KFDGLWIDMN
EPSSFVNGTT SNQCRNERLN YPPYSPALTK RYEGLHFRTM CMETEQILSD GSSVLHYDVH
NLYGWSQIKP TYDALQKTTG KRGIVISRST YPTAGRWSGH WLGDNYARWD NLDKSIIGMM
EFSLFGISYT GADICGFFND SEYHLCTRWT QLGAFYPYSR NHNIAFTRRQ DPVSWNETFA
TMARDVLNIR YNLLPYFYTQ MHDIHAHGGT VIRPLMHEFF DEKETWDVFE QFLWGPAFMV
TPVLTPYAES VRGYVPNARW FDYHTGLDIG VRGQFHVFNA PFDTINLHVR GGHILPCQEP
AQNTHFSRQN HMKLIVAADD NQMAQGTLFW DDGDSIDTYE RDLYFLAQFN LNKTTLTSTI
LKNGYINKSE MILGLIYVLG KGNTPVNAVN LIYKENTVSV TFNQDAANQL LTIDLRTEHV
TLDEPFEISW S
//