ID H0WHQ5_OTOGA Unreviewed; 697 AA.
AC H0WHQ5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Methionine synthase reductase {ECO:0000256|ARBA:ARBA00040659};
DE EC=1.16.1.8 {ECO:0000256|ARBA:ARBA00039088};
GN Name=MTRR {ECO:0000313|Ensembl:ENSOGAP00000000920.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000000920.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000000920.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
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DR EMBL; AAQR03065011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03065012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03065013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03065014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03065015; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03065016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WHQ5; -.
DR STRING; 30611.ENSOGAP00000000920; -.
DR Ensembl; ENSOGAT00000001030.2; ENSOGAP00000000920.2; ENSOGAG00000001029.2.
DR eggNOG; KOG1158; Eukaryota.
DR GeneTree; ENSGT00940000155822; -.
DR HOGENOM; CLU_001570_17_7_1; -.
DR InParanoid; H0WHQ5; -.
DR OMA; LFFGHQR; -.
DR TreeFam; TF105716; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0045111; C:intermediate filament cytoskeleton; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0030586; F:[methionine synthase] reductase activity; IEA:Ensembl.
DR GO; GO:0071949; F:FAD binding; IEA:Ensembl.
DR GO; GO:0010181; F:FMN binding; IEA:Ensembl.
DR GO; GO:0070402; F:NADPH binding; IEA:Ensembl.
DR GO; GO:0003958; F:NADPH-hemoprotein reductase activity; IEA:Ensembl.
DR GO; GO:0046655; P:folic acid metabolic process; IEA:Ensembl.
DR GO; GO:0043418; P:homocysteine catabolic process; IEA:Ensembl.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd06203; methionine_synthase_red; 1.
DR Gene3D; 3.40.50.360; -; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR001094; Flavdoxin-like.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR19384:SF84; METHIONINE SYNTHASE REDUCTASE; 1.
DR PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00667; FAD_binding_1; 1.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR PRINTS; PR00369; FLAVODOXIN.
DR PRINTS; PR00371; FPNCR.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643};
KW Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 4..147
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 271..532
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 697 AA; 77672 MW; 74FC8AD235849D47 CRC64;
MRRFLLLYAT QRGQAKAIAE EICEQAVAHG FSADLHCISE ADKYDLKTET APLVVVVSTT
GTGDPPDTAR KFVKEIQNKT LPVDFFAHLR YGLLGLGDSE YTYFCNGGKI IDKRLQELGA
RHFYDTGHAD DCVGLELVVE PWISGLWAAL TEHFQSNREQ EKINGALSMT SPAPPKTDPG
KPELLHLQSR IELLRVDDSG GTDSEVLQQN AVNSGQSSAL IEDFEPSLTR SVPPLSQASL
NIPALPPDYL EVRLQESLNQ EESRAPVTSG DPVFQVPVSK AVQLTTNDAL KTTLLVELDV
SKTDFSYQPG DAFNVICPNS DSEVQSLLHR LQLADRRESR VLLRMKADTR KKGAVLPRHI
PEGCSLQFIF TWCLEIRAIP KKAFLRALAD YTSDSAEKRR LQELCSRQGA AEYGRFLRDS
CTCLLDLLLA FPSCQPPLGL LLEHLPKLQP RPYSCASSSL YHPGKLHFIF NVVEFLSNTT
MVLRRGVCTG WLATLVASFL QPSTNVSHED RGRALAPKIS ISPRTTNSFH LPDDPSAPII
MVGPGTGIAP FLGFLQHREK LQEQHPDGNF GAMWLFFGCR HQDRDYLFRE ELRHFLNLGI
LTHLKVSFSR DARVGEEDAP AKYVQDNLQL HGKQVAGLLL HEGGYIYVCG DAKNMAKDVN
DALVEIISRE VGVEKLEAMR TLATLKEEKR YLQDIWS
//
