ID H0WPF4_OTOGA Unreviewed; 875 AA.
AC H0WPF4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DDX54 {ECO:0000313|Ensembl:ENSOGAP00000003762.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000003762.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000003762.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX54/DBP10
CC subfamily. {ECO:0000256|ARBA:ARBA00010379}.
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DR EMBL; AAQR03070950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03070951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003790009.2; XM_003789961.2.
DR AlphaFoldDB; H0WPF4; -.
DR STRING; 30611.ENSOGAP00000003762; -.
DR Ensembl; ENSOGAT00000004215.2; ENSOGAP00000003762.2; ENSOGAG00000004210.2.
DR GeneID; 100954393; -.
DR KEGG; oga:100954393; -.
DR CTD; 79039; -.
DR eggNOG; KOG0337; Eukaryota.
DR GeneTree; ENSGT00550000075100; -.
DR HOGENOM; CLU_003041_5_2_1; -.
DR InParanoid; H0WPF4; -.
DR OMA; EDQFGMM; -.
DR OrthoDB; 5475716at2759; -.
DR TreeFam; TF105707; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0030331; F:nuclear estrogen receptor binding; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR GO; GO:0006396; P:RNA processing; IEA:Ensembl.
DR CDD; cd17959; DEADc_DDX54; 1.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR012541; DBP10_C.
DR InterPro; IPR033517; DDX54/DBP10_DEAD-box_helicase.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR PANTHER; PTHR47959:SF8; RNA HELICASE; 1.
DR Pfam; PF08147; DBP10CT; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM01123; DBP10CT; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 96..124
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 127..299
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 326..472
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 765..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 847..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 96..124
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
FT COMPBIAS 33..58
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..639
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..688
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..748
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..795
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 875 AA; 98162 MW; 6CCE6C70CAC821DE CRC64;
MAAGTRPAAG PRSRDAMAQW RKKKGLRKRR GAALQTRSSD SEDGEFEIQA EDDARVQKLG
PGRPLPTFPT SECTSDVEPD TREMVRAQNK KKKKSGGFQS MGLSYPVFKG IMKKGYKVPT
PIQRKTIPVI LDGKDVVAMA RTGSGKTACF LLPMFERLKT RSAQTGARAL ILSPTRELAL
QTMKFTKELG KFTGLKTALI LGGDKMEDQF AALHENPDII IATPGRLVHV AVEMNLKLQS
VEYVVFDEAD RLFEMGFAEQ LQEIIARLPD GHQTVLFSAT LPKLLVEFAR AGLTEPVLIR
LDVDAKLNEQ LKTSFFLVRE DTKAAVLLYL LRNVVRPQDQ TVVFVATKHH AEYLTELLTA
QCVSCTHIYS ALDQTARKIN LAKFTLGKCS TLIVTDLAAR GLDIPLLDNV INYSFPAKGK
LFLHRVGRVA RAGRSGTAYS LVAPDEVPYL LDLHLFLGRA LTLAHPHEES SGLVGVDGVL
GRVPQSVVDE EDSGLRSALE KSLELRGLGR VADNAQQQYV RSRPAPSPES IKRAKELDLV
GLSLHPLFSS CFEEEELQRL RLVDSIKNYR SRATIFEINT SSRDLSSQVM RAKRQKDRKA
IARFQQVRQK GLVGPVLSHP ALQEEQPEEE EEEDPGESVE NVFTEILGRK RQQPGPNMGA
KRRREEARQR DQEFYVPYRP KDFDSERGLS VGGDGGTFEQ QVTGAVLDLM GDETQNLTRG
RQQLKWDRKK KRFVGQSGQE DKKKIKTESG GFISSSYKRD LYQKWKQKQK IDDRDSEEEG
ASDRRGPERR GGKRGRGRGS SQPRIPGTPA GHVRSELKTK QQILKQRRRT QKLRFLQRGG
LKQLSARNRH RVQELQQGAF GRGARSKKGK MRKRM
//
