ID H0WU64_OTOGA Unreviewed; 398 AA.
AC H0WU64;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Lipase {ECO:0000256|PIRNR:PIRNR000862};
GN Name=LIPK {ECO:0000313|Ensembl:ENSOGAP00000005741.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000005741.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000005741.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|PIRNR:PIRNR000862}.
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DR EMBL; AAQR03020006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03020007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003783730.1; XM_003783682.1.
DR AlphaFoldDB; H0WU64; -.
DR STRING; 30611.ENSOGAP00000005741; -.
DR MEROPS; S33.020; -.
DR Ensembl; ENSOGAT00000006425.2; ENSOGAP00000005741.2; ENSOGAG00000006423.2.
DR GeneID; 100961057; -.
DR KEGG; oga:100961057; -.
DR CTD; 643414; -.
DR eggNOG; KOG2624; Eukaryota.
DR GeneTree; ENSGT00940000160031; -.
DR HOGENOM; CLU_010974_0_0_1; -.
DR InParanoid; H0WU64; -.
DR OMA; GYPYEKY; -.
DR OrthoDB; 5474043at2759; -.
DR TreeFam; TF315485; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR025483; Lipase_euk.
DR PANTHER; PTHR11005:SF45; LIPASE MEMBER K; 1.
DR PANTHER; PTHR11005; LYSOSOMAL ACID LIPASE-RELATED; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR PIRSF; PIRSF000862; Steryl_ester_lip; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR000862};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963,
KW ECO:0000256|PIRNR:PIRNR000862};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..398
FT /note="Lipase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003543984"
FT DOMAIN 77..377
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
FT ACT_SITE 171
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 342
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 371
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
SQ SEQUENCE 398 AA; 45359 MW; FA2657E853A893D5 CRC64;
MWQLLTAACW MLLLGSICGS KKRTTTNPEA NMNISQIISY WGYPHEEYDV ATKDGYILGL
YRIPHGRGCP PQTASKPVVY LQHGLVASAS NWICNLPNNS LAFILADTGY DVWLGNSRGN
TWSRKHLKLS PKSSEYWAFS LDEMSKYDLP ATINFILEKT GQEQLYYVGH SQGTTIAFIA
FSTNPELAKR IKTFFALAPV VTVKYTKSPM KKLTTLSRQV VKVLFGDKMF YPHTLFNQYI
ATKVCNQKLF HRICSNFLFT LCGFDAKNLN MSRLDVYLSQ NPAGTSVQTM LHWAQAVNSG
QLQAFDWGNP DENLMHFHQL IPPLYNVTKM EIPTAMWSGG QDVVADPKDV ENLLPKIANL
IYYKLIPHYN HVDFYLGQDA PQEIYQDLVR LIEQWKQN
//
