ID H0WUY9_OTOGA Unreviewed; 1151 AA.
AC H0WUY9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Protein phosphatase 2 regulatory subunit B''alpha {ECO:0000313|Ensembl:ENSOGAP00000006095.2};
GN Name=PPP2R3A {ECO:0000313|Ensembl:ENSOGAP00000006095.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000006095.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000006095.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03062239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062241; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062245; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062246; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062248; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003789459.1; XM_003789411.2.
DR AlphaFoldDB; H0WUY9; -.
DR STRING; 30611.ENSOGAP00000006095; -.
DR Ensembl; ENSOGAT00000006815.2; ENSOGAP00000006095.2; ENSOGAG00000006811.2.
DR GeneID; 100961106; -.
DR KEGG; oga:100961106; -.
DR CTD; 5523; -.
DR eggNOG; KOG2562; Eukaryota.
DR GeneTree; ENSGT00940000154659; -.
DR HOGENOM; CLU_276803_0_0_1; -.
DR InParanoid; H0WUY9; -.
DR OMA; VQKPASH; -.
DR OrthoDB; 918215at2759; -.
DR TreeFam; TF105554; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0000159; C:protein phosphatase type 2A complex; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd21506; PPP2R3A; 1.
DR Gene3D; 1.10.238.220; -; 1.
DR Gene3D; 1.10.238.230; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR041534; EF-hand_13.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR048855; P2R3A_B_D_EF-hand.
DR PANTHER; PTHR14095; PHOSPHATASE 2A REGULATORY SUBUNIT-RELATED; 1.
DR PANTHER; PTHR14095:SF3; SERINE_THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT ALPHA; 1.
DR Pfam; PF17958; EF-hand_13; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF21161; P2R3B_EF-hand; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 972..1007
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 356..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1102..1130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1151 AA; 130198 MW; A36D1D97000DE046 CRC64;
MAATYRLVVS TVNHYSSVVI DRRFEQAIHY CTGTCHTFTH GVDCIVVHHS VCADLLHIPV
SPFKDADLNS MFLPHENGLS SAEGDYPHQA LTGIPKVKRG STFQNTCNLK DIAGEAISFA
SGKIKEFSLE KLKNSNHATY RKGRKVKSDS FNRRSVDFDL LYGQYNNDGN SPSFGLLRSS
SVEEKSLSHR NSLDTNLASM LLQNFSEEDL VTQILEKHKI DHFSSGTDIK MCLDILLKCS
EDLKKCTDII KQCIKKKSGG SLNEGSGNDT VASSETVYMN VMTRLTSYLK KLPFEFMHSA
NTEAIDLTEL VNNLPSLQLT PFSLMFGNEQ PPKYEDVVQL SAPDSGQFQT IELQDDKQNS
RKMDTVKPIP NNSTNSLYNL EVNDPRTLKP VQLQSQSLTM NPLETVSSDG LIETLYIEEE
SDEKKALDKG QKTENGPSQE LLKKTEHRAE FSEHDTHLKK CPASVQSEIG NIFEKPFVHL
SQEDCKSQSP KVARGDQKDF MNSNSQEEID KLLMDLESFS QKMETSLREP LAKNKNSNSL
NSHGQLTGQT PIDLESKSKG SLSVEKVSPS CLTRIIETNG HKIEEEDRAL LLRILESIED
FAQELVECKS GRGSLSQEKE MMQILQETLT TSSQANLSVC RSPVGDKAKD TTSVVLIQQT
PEVIKIQNKP EKKSGTPLPL PATFPSSPRP LSPVSHVNNV VNAPLSINIP RFYFPEGLPD
ACSNHEQTLS RIETAFMDIE DQKADIYEMG KIAKVCGCPL YWKAPMFRAA GGEKTGFVSS
QSFIAMWRKL LNNHHDDASK FICLLAKPSC SSLEQEDFIP LLQDVVDTHP GLTFLKDAPE
FHSRYITTVI QRIFYTVNRS WTGKITSTEI RKSNFLQTLA LLEEEEDINQ ITDYFSYEHF
YVIYCKFWEL DSDHDLYISQ ADLSRYNDQA SSNRIIERIF SGAVTRGKTV QKEGRMSYAD
FVWFLISEED KRNPTSIEYW FRCMDVDGDG VLSMYELEYF YEEQCERMEA MGIEPLPFHD
LLCQMLDLVK PANDGKITLR DLKRCRMAHI FYDTFFNLEK YLDHEQRDPF AVQKDVENEG
PEPSDWDRFA AEEYETLVAE ESAQAQLQEG SFEDYEIDEP ASPSEFGNKA NKIINSSLSE
KCGKLQSVDE E
//
