ID H0WVF7_OTOGA Unreviewed; 354 AA.
AC H0WVF7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Clavesin-1 {ECO:0000256|ARBA:ARBA00013640};
DE AltName: Full=Retinaldehyde-binding protein 1-like 1 {ECO:0000256|ARBA:ARBA00031838};
GN Name=CLVS1 {ECO:0000313|Ensembl:ENSOGAP00000006291.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000006291.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000006291.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle
CC {ECO:0000256|ARBA:ARBA00004132}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004150}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
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DR EMBL; AAQR03177599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03177600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03177601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03177602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03177603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03177604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03177605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03177606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03177607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03177608; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003802217.1; XM_003802169.2.
DR AlphaFoldDB; H0WVF7; -.
DR STRING; 30611.ENSOGAP00000006291; -.
DR Ensembl; ENSOGAT00000007031.2; ENSOGAP00000006291.2; ENSOGAG00000007028.2.
DR GeneID; 100954060; -.
DR KEGG; oga:100954060; -.
DR CTD; 157807; -.
DR eggNOG; KOG1471; Eukaryota.
DR GeneTree; ENSGT00940000159947; -.
DR HOGENOM; CLU_046597_1_3_1; -.
DR InParanoid; H0WVF7; -.
DR OMA; DMMKRSQ; -.
DR OrthoDB; 2943211at2759; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:Ensembl.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 1.20.5.1200; Alpha-tocopherol transfer; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.10.8.20; N-terminal domain of phosphatidylinositol transfer protein sec14p; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011074; CRAL/TRIO_N_dom.
DR InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR PANTHER; PTHR10174; ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED; 1.
DR PANTHER; PTHR10174:SF72; CLAVESIN-1; 1.
DR Pfam; PF00650; CRAL_TRIO; 1.
DR Pfam; PF03765; CRAL_TRIO_N; 1.
DR PRINTS; PR00180; CRETINALDHBP.
DR SMART; SM01100; CRAL_TRIO_N; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF46938; CRAL/TRIO N-terminal domain; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 118..279
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 311..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 354 AA; 40649 MW; 750F8E4D64ADF6CA CRC64;
MGPVSLLPKY QKLSNCKGDL AKMTHLQAGL SPETIEKARL ELNENADVLH QDIQQVRDMI
ITRPDIGFLR TDDAFILRFL RARKFHQADA FRLLAQYFQY RQLNLDMFKN FKADDPGIKR
ALIDGFPGVL ENRDHYGRKI LLLFAANWDQ SRNSFTDILR AILLSLEVLI EDPELQINGF
ILIIDWSNFS FKQASKLTPS ILKLAIEGLQ DSFPARFGGV HFVNQPWYIH ALYTLIKPFL
KDKTRKRIFL HGNNLNSLHQ LIHPEFLPSE FGGTLPPYDM GTWARTLLGP DYSDENDYTH
TSYNAMHVKH TSSNLERECS PKPMKRSQSV VEAGTLKHEE KGENDNTQPL LALD
//
